Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle.

Autor: Elyse K Paterson, Thomas J Fielder, Grant R MacGregor, Shosuke Ito, Kazumasa Wakamatsu, Daniel L Gillen, Victoria Eby, Raymond E Boissy, Anand K Ganesan

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143702 (2015)

The mechanisms that lead to variation in human skin and hair color are not fully understood. To better understand the molecular control of skin and hair color variation, we modulated the expression of Tyrosinase (Tyr), which controls the rate-limitin

Externí odkaz: https://doaj.org/article/f686141cdd10446dbe864532116f42bf

Comparison of male chimeric mice generated from microinjection of JM8.N4 embryonic stem cells into C57BL/6J and C57BL/6NTac blastocysts

Autor: Douglas C. Wallace, Shuling Wang, Kai-Xuan Shi, Charles S. Yi, Hsiao-Wen Chen, Katrina G. Waymire, Juliet Masumi, Grant R. MacGregor, Thomas J. Fielder

To identify ways to improve the efficiency of generating chimeric mice via microinjection of blastocysts with ES cells, we compared production and performance of ES-cell derived chimeric mice using blastocysts from two closely related and commonly us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3384a9c8f405f5af07b2174d8a3bab24
https://europepmc.org/articles/PMC3445772/

Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice

Autor: Lisa A. McConnachie, Ulrike Luderer, Yvonne D. Hoang, Terrance J. Kavanagh, Thomas J. Fielder, Jinhwan Lim, Brooke N. Nakamura

Publikováno v: Nakamura, BN; Fielder, TJ; Hoang, YD; Lim, J; McConnachie, LA; Kavanagh, TJ; et al.(2011). Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice. Endocrinology, 152(7), 2806-2815. doi: 10.1210/en.2011-0207. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3443c48z

Glutathione (GSH) is the most abundant intracellular thiol and an important regulator of cellular redox status. Mice that lack the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, have decreased GSH syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1273c253d5d452cffa62a95a0ff40704
http://www.escholarship.org/uc/item/3443c48z

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Autor: Glenn Barnes, James F. Gusella, Francis S. Collins, Annemarie Poustka, S. Youngman, Sarah Baxendale, Duncan Shaw, Richard H. Myers, John Valdes, Barbara Jenkins, Marcy E. MacDonald, Karen M. Draths, Sherryl A.M. Taylor, Gillian P. Bates, Lucio H. Castilla, Alan Buckler, Thomas J. Fielder, John J. Wasmuth, Carol Lin, Lakshmi Srinidhi, Nicole A. Datson, Mabel P. Duyao, Christine Ambrose, Susan F. Kirby, Michael R. Altherr, Manju Swaroop, Peter S. Harper, Zdenek Sedlacek, Marc W. Allard, Mike North, Russell G. Snell, Rita Shiang, David E. Housman, Lawrence W. Elmer, Marianne James, Richard Mott, Kathleen Gillespie, Leslie M. Thompson, Laura Riba-Ramirez, Nancy S. Wexler, Deanna M. Church, Günther Zehetner, Scott A. Strobel, Heather MacFarlane, Anna-Maria Frischauf, Mary Anne Anderson, Hans Lehrach, Michael Conlon O'Donovan, Vincent P. Stanton, Kris Blanchard, Danilo A. Tagle, Lynn Doucette-Stamm, Holger Hummerich, Tracey Holloway, Manish A. Shah, Jennifer L. Wales, Nicolet Groot, Peter B. Dervan

Publikováno v: Cell. 72:971-983

The Huntington's disease (HD) gene has been mapped in 4p16.3 but has eluded identification. We have used haplotype analysis of linkage disequilibrium to spotlight a small segment of 4p16.3 as the likely location of the defect. A new gene, 1715, isola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1873dad00d376a44a1a9d14831b8246f
https://doi.org/10.1016/0092-8674(93)90585-e

Functional and structural mapping of Chlamydia trachomatis species-specific major outer membrane protein epitopes by use of neutralizing monoclonal antibodies

Autor: L M de la Maza, Thomas J. Fielder, Xun Cheng, B A Markoff, Ellena M. Peterson

Publikováno v: Infection and Immunity. 59:4147-4153

Three monoclonal antibodies (MAbs), E4, L1-4, and L1-24, to the major outer membrane protein (MOMP) of Chlamydia trachomatis were identified that neutralized in vitro the infectivity of members of the B- and C-related complex as well as the mouse pne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7050072c13d68b4c74c9ea274407b61d
https://doi.org/10.1128/iai.59.11.4147-4153.1991