Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thomas J Alsted"'
Autor:
Christian Frøsig, Thomas E Jensen, Jacob Jeppesen, Christian Pehmøller, Jonas T Treebak, Stine J Maarbjerg, Jonas M Kristensen, Lykke Sylow, Thomas J Alsted, Peter Schjerling, Bente Kiens, Jørgen F P Wojtaszewski, Erik A Richter
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62338 (2013)
The 5'-AMP-activated protein kinase (AMPK) is considered "a metabolic master-switch" in skeletal muscle reducing ATP- consuming processes whilst stimulating ATP regeneration. Within recent years, AMPK has also been proposed as a potential target to a
Externí odkaz:
https://doaj.org/article/dc98e45ee71b43d38484f0835f31be3d
Autor:
Gabriele Schoiswohl, Martina Schweiger, Renate Schreiber, Gregor Gorkiewicz, Karina Preiss-Landl, Ulrike Taschler, Kathrin A. Zierler, Franz P.W. Radner, Thomas O. Eichmann, Petra C. Kienesberger, Sandra Eder, Achim Lass, Guenter Haemmerle, Thomas J. Alsted, Bente Kiens, Gerald Hoefler, Rudolf Zechner, Robert Zimmermann
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 3, Pp 490-499 (2010)
FAs are mobilized from triglyceride (TG) stores during exercise to supply the working muscle with energy. Mice deficient for adipose triglyceride lipase (ATGL-ko) exhibit defective lipolysis and accumulate TG in adipose tissue and muscle, suggesting
Externí odkaz:
https://doaj.org/article/e6767bddb33b4e44b985ee5aa3151637
Autor:
Jeannette S. Kirkegaard, Tess T. H. Lu, Camilla Ingvorsen, Dorthe Roenn Petersen, Maria J. Pereira, Thomas J. Alsted, Nikolai K. Jensen, Kevin A. Keane
Publikováno v:
Toxicologic pathology. 49(7)
Islet-like clusters derived from human embryonic stem cells (hESC) hold the potential to cure type 1 diabetes mellitus. Differentiation protocols of islet-like clusters lead to the generation of minor fractions of nonendocrine cells, which are mainly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23101c3bc21d6a12688dd02b06391d5
https://pubmed.ncbi.nlm.nih.gov/34555946
https://pubmed.ncbi.nlm.nih.gov/34555946
Autor:
Claus Bekker Jeppesen, Thomas R. Pieber, Christian Höfferer, Frank Sinner, Selma Mautner, D. Tutkur, Thomas J. Alsted, Erica Nishimura, J. Damgaard, Christian Fledelius, Christian L. Brand
Publikováno v:
Diabetes, Obesity and Metabolism. 17:121-127
Aims To compare the time profile of insulin detemir and human insulin concentrations in the interstitial fluid (ISF) of subcutaneous adipose tissue during constant i.v. infusion and to investigate the relationship between the pharmacokinetics of both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f1551cf400dd4db9ba3eca918aee10
https://doi.org/10.1111/dom.12394
https://doi.org/10.1111/dom.12394
Autor:
Annette K. Serup, Henrik Galbo, Bente Kiens, Louise D. Høeg, Cecilia Holm, Peter Schjerling, Robert Zimmermann, Thomas J. Alsted, Thorkil Ploug, Christian Fledelius, Clara Prats
Publikováno v:
The Journal of Physiology. 591:5141-5155
In skeletal muscle hormone-sensitive lipase (HSL) has long been accepted to be the principal enzyme responsible for lipolysis of intramyocellular triacylglycerol (IMTG) during contractions. However, this notion is based on in vitro lipase activity da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8891daea6d92b0ec1f0ccf59e2970a9e
https://doi.org/10.1113/jphysiol.2013.260794
https://doi.org/10.1113/jphysiol.2013.260794
Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice
Autor:
Mark A. Febbraio, Thomas J. Alsted, Caroline Rudnicka, Claus Brandt, Matthew J. Watt, Tamara L Allen, Birgitte Lindegaard, Henriette Pilegaard, Juan Hidalgo, Bente Klarlund Pedersen, Susanne Ditlevsen, Clinton R. Bruce, Emma Estevez, Pernille Hojman, Ole Steen Mortensen, Julie Abildgaard, Susanne Syberg, Andreas N. Madsen, Vance B. Matthews
Publikováno v:
Diabetes
Circulating interleukin (IL)-18 is elevated in obesity, but paradoxically causes hypophagia. We hypothesized that IL-18 may attenuate high-fat diet (HFD)-induced insulin resistance by activating AMP-activated protein kinase (AMPK). We studied mice wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e57e1f5d49ce60ef295050eecbdc58
https://doi.org/10.2337/db12-1095
https://doi.org/10.2337/db12-1095
Autor:
Cecilia Holm, Thomas J. Alsted, Andreas Børsting Jordy, Annette K. Serup, Bente Kiens, Peter Schjerling
Publikováno v:
Diabetes. 65(10)
Type 2 diabetes and skeletal muscle insulin resistance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG). However, recent animal and human studies have questioned such an association. Given that DAG appe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae91a2ac41c8b083a02736f6447bff3
https://pubmed.ncbi.nlm.nih.gov/27489310
https://pubmed.ncbi.nlm.nih.gov/27489310
Publikováno v:
Obesity Reviews. 12:852-858
In modern societies, oversupply of calories leads to obesity and chronic metabolic stress, which may lead to development of disease. Oversupply of calories is often associated with elevated plasma lipid concentrations and accumulation of lipids in sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a87cfde894db0a4cd3ec720ec5f1ad1b
https://doi.org/10.1111/j.1467-789x.2011.00898.x
https://doi.org/10.1111/j.1467-789x.2011.00898.x
Autor:
Robert Zimmermann, Guenter Haemmerle, Thomas O. Eichmann, Gerald Hoefler, Achim Lass, Renate Schreiber, Karina Preiss-Landl, Bente Kiens, Martina Schweiger, Petra C. Kienesberger, Thomas J. Alsted, Gabriele Schoiswohl, Franz P.W. Radner, Sandra Eder, Gregor Gorkiewicz, Kathrin A. Zierler, Ulrike Taschler, Rudolf Zechner
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 3, Pp 490-499 (2010)
FAs are mobilized from triglyceride (TG) stores during exercise to supply the working muscle with energy. Mice deficient for adipose triglyceride lipase (ATGL-ko) exhibit defective lipolysis and accumulate TG in adipose tissue and muscle, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0890f37ed9d52fd0c0ed1afce02f077
http://www.sciencedirect.com/science/article/pii/S0022227520305071
http://www.sciencedirect.com/science/article/pii/S0022227520305071
Autor:
Erik A. Richter, Adam J. Rose, Thomas J. Alsted, Stine Maarbjerg, Jørgen Jensen, J. Bjarke Kobberø, Thomas E. Jensen
Publikováno v:
The Journal of Physiology. 587:1547-1563
Skeletal muscle protein synthesis rate decreases during contractions but the underlying regulatory mechanisms are poorly understood. It was hypothesized that there would be a coordinated regulation of eukaryotic elongation factor 2 (eEF2) and eukaryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7bfcffac5e5df98992ca1f9be99a4e9
https://doi.org/10.1113/jphysiol.2008.167528
https://doi.org/10.1113/jphysiol.2008.167528