Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Thomas J, Turbyville"'
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The oncogene RAS, extensively studied for decades, presents persistent gaps in understanding, hindering the development of effective therapeutic strategies due to a lack of precise details on how RAS initiates MAPK signaling with RAF effecto
Externí odkaz:
https://doaj.org/article/c9c372b885d34294a1a4b151fe83ce95
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/ebd31f95883b42a68c6081c546cb6fe3
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103608- (2022)
Summary: Understanding the spatiotemporal distribution and dynamics of RAS on the plasma membrane (PM) is the key for elucidating the molecular mechanisms of the RAS signaling pathway. Single particle tracking (SPT) experiments show that in cells, KR
Externí odkaz:
https://doaj.org/article/b2082f6fe93940f0966c6fc4a2000b8a
Autor:
Cesar A. López, Xiaohua Zhang, Fikret Aydin, Rebika Shrestha, Que N. Van, Christopher B. Stanley, Timothy S. Carpenter, Kien Nguyen, Lara A. Patel, De Chen, Violetta Burns, Nicolas W. Hengartner, Tyler J. E. Reddy, Harsh Bhatia, Francesco Di Natale, Timothy H. Tran, Albert H. Chan, Dhirendra K. Simanshu, Dwight V. Nissley, Frederick H. Streitz, Andrew G. Stephen, Thomas J. Turbyville, Felice C. Lightstone, Sandrasegaram Gnanakaran, Helgi I. Ingólfsson, Chris Neale
Publikováno v:
Journal of Chemical Theory and Computation. 18:5025-5045
The appeal of multiscale modeling approaches is predicated on the promise of combinatorial synergy. However, this promise can only be realized when distinct scales are combined with reciprocal consistency. Here, we consider multiscale molecular dynam
Autor:
Karlyne M. Reilly, John A. Beutler, David F. Wiemer, Stephen J. Lockett, Claudia A. Lipschultz, Jessica C. Walrath, Robert G. Tuskan, Demirkan B. Gürsel, Thomas J. Turbyville
Neurofibromatosis type 1 (NF1) is the most common genetic disease affecting the nervous system. Patients typically develop many tumors over their lifetime, leading to increased morbidity and mortality. The NF1 gene, mutated in NF1, is also commonly m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70e91fdd3394001ccb22c31934e7665
https://doi.org/10.1158/1535-7163.c.6531789.v1
https://doi.org/10.1158/1535-7163.c.6531789.v1
Autor:
Karlyne M. Reilly, John A. Beutler, David F. Wiemer, Stephen J. Lockett, Claudia A. Lipschultz, Jessica C. Walrath, Robert G. Tuskan, Demirkan B. Gürsel, Thomas J. Turbyville
Supplementary Data from Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis Type 1 Tumor Cells in a NF1-GRD–Dependent Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e32dacb0d0ff559bb01b60a90cb604
https://doi.org/10.1158/1535-7163.22485129.v1
https://doi.org/10.1158/1535-7163.22485129.v1
Supplementary Methods, Figures 1-5 from Carminomycin I Is an Apoptosis Inducer That Targets the Golgi Complex in Clear Cell Renal Carcinoma Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366b258a0b354f56406daf703c56b9c7
https://doi.org/10.1158/0008-5472.22387065.v1
https://doi.org/10.1158/0008-5472.22387065.v1
Autor:
Que N. Van, Priyanka Prakash, Rebika Shrestha, Trent E. Balius, Thomas J. Turbyville, Andrew G. Stephen
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 377 (2021)
RAS proteins are mutated in approximately 20% of all cancers and are generally associated with poor clinical outcomes. RAS proteins are localized to the plasma membrane and function as molecular switches, turned on by partners that receive extracellu
Externí odkaz:
https://doaj.org/article/398a71e792b1472fa938e22953542dcb
Autor:
Rebika Shrestha, Thomas J. Turbyville, Torin McDonald, Valerio Pascucci, Harsh Bhatia, Peer-Timo Bremer, Xiyu Yi, De Chen, Debanjan Goswami
Publikováno v:
Computer Graphics Forum. 40:251-262
Autor:
Harsh Bhatia, Dwight V. Nissley, Arthur F. Voter, Helgi I. Ingólfsson, Frank McCormick, Sumantra Sarkar, Debanjan Goswami, Gulcin Gulten, Timothy S. Carpenter, Sara Kokkila Schumacher, Frederick H. Streitz, Peer-Timo Bremer, Jeevapani J. Hettige, Xiaohua Zhang, Liam Stanton, Shusen Liu, Yue Yang, Arvind Ramanathan, Nicolas W. Hengartner, Timothy H. Tran, Dhirendra K. Simanshu, Thomas J. Turbyville, Rebika Shrestha, Constance Agamasu, Shiv Sundram, Michael P. Surh, Brian Van Essen, Cesar A. Lopez, Tomas Oppelstrup, Timothy Travers, James N. Glosli, Felice C. Lightstone, Andrew G. Stephen, Frantz Jean-Francios, De Chen, Chris Neale, Que Van, Sandrasegaram Gnanakaran, Francesco Di Natale, Adam Moody, Gautham Dharuman, Animesh Agarwal
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 1
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Here we present an unprecedented multiscale simulation platform that enables modeling, hypothesis generation, and discovery across biologically relevant length and time scales to predict mechanisms that can be tested experimentally. We d