Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Thomas J, Park"'
Phenylpropanoid-enriched broccoli seedling extract can reduce inflammatory markers and pain behavior
Autor:
Aleksandra A. Gurgul, Yahya Najjar, Ana Chee, Howard An, Chun-Tao Che, Thomas J. Park, Katherine M. Warpeha
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Pain is a worldwide problem requiring an effective, affordable, non-addictive therapy. Using the edible plant broccoli, a growth protocol was developed to induce a concentrated combinatorial of potential anti-inflammatories in see
Externí odkaz:
https://doaj.org/article/667ea18d56504f4880d793f4d6659877
Autor:
Csaba Kerepesi, Margarita V. Meer, Julia Ablaeva, Vince G. Amoroso, Sang-Goo Lee, Bohan Zhang, Maxim V. Gerashchenko, Alexandre Trapp, Sun Hee Yim, Ake T. Lu, Morgan E. Levine, Andrei Seluanov, Steve Horvath, Thomas J. Park, Vera Gorbunova, Vadim N. Gladyshev
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The exceptionally long-lived naked mole-rat is characterized by the lack of increased mortality with aging. Here the authors perform epigenetic studies to show that naked mole-rats epigenetically age despite their non-increasing mortality rate.
Externí odkaz:
https://doaj.org/article/44f348039b714784b3968f7be0bc9284
Naked Mole-Rats Demonstrate Profound Tolerance to Low Oxygen, High Carbon Dioxide, and Chemical Pain
Publikováno v:
Animals, Vol 13, Iss 5, p 819 (2023)
Naked mole-rats (Heterocephalus glaber) are very unusual among subterranean mammals in that they live in large colonies and are extremely social, spending large amounts of time gathered together in underground nests more than a meter below the surfac
Externí odkaz:
https://doaj.org/article/4c837457766c45778f63db4540250cc0
Publikováno v:
The Journal of Physiology. 601:607-629
Autor:
Brigitte M. Browe, Abigail R. Olsen, Cesar Ramirez, Rebecca H. Rickman, Ewan St. John Smith, Thomas J. Park
Publikováno v:
Neurobiology of Pain, Vol 8, Iss , Pp 100047- (2020)
Naked mole-rats (Heterocephalus glaber) have adaptations within their pain pathway that are beneficial to survival in large colonies within poorly ventilated burrow systems, with lower O2 and higher CO2 ambient levels than ground-level environments.
Externí odkaz:
https://doaj.org/article/4f5fe742a12a47258cac8ae46ff4e08d
Autor:
Peiheng Gan, Michaela Patterson, Alexa Velasquez, Kristy Wang, Di Tian, Jolene J Windle, Ge Tao, Daniel P Judge, Takako Makita, Thomas J Park, Henry M Sucov
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008354 (2019)
Recent evidence implicates mononuclear diploid cardiomyocytes as a proliferative and regenerative subpopulation of the postnatal heart. The number of these cardiomyocytes is a complex trait showing substantial natural variation among inbred mouse str
Externí odkaz:
https://doaj.org/article/b0cd004e06be40bea92e5a2d3d6387fa
Autor:
Sang-Goo Lee, Aleksei E. Mikhalchenko, Sun Hee Yim, Alexei V. Lobanov, Jin-Kyu Park, Kwang-Hwan Choi, Roderick T. Bronson, Chang-Kyu Lee, Thomas J. Park, Vadim N. Gladyshev
Publikováno v:
Stem Cell Reports, Vol 9, Iss 5, Pp 1706-1720 (2017)
Summary: Naked mole rats (NMRs) are exceptionally long-lived, cancer-resistant rodents. Identifying the defining characteristics of these traits may shed light on aging and cancer mechanisms. Here, we report the generation of induced pluripotent stem
Externí odkaz:
https://doaj.org/article/eb7d6286eee14502b11e878d58eaf0b3
Autor:
Thomas J. Park
Publikováno v:
Oxford Research Encyclopedia of Neuroscience ISBN: 9780190264086
Naked mole-rats are subterranean mammals that are native to equatorial east Africa including Ethiopia, Somalia, and Kenya. They are unusual among subterranean mammals in that they live in very large colonies where many respiring animals deplete oxyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537005c0ac7014ee6664b953c80ae0b0
https://doi.org/10.1093/acrefore/9780190264086.013.487
https://doi.org/10.1093/acrefore/9780190264086.013.487
Autor:
Elise Parey, Stephanie Frost, Ainhoa Uribarren, Thomas J. Park, Markus Zoettl, Ewan St. John Smith, Camille Berthelot, Diego Villar
Changes in gene regulation have long been thought to underlie most phenotypic differences between species. Subterranean rodents, and in particular the naked mole-rat, have attracted substantial attention due to their proposed phenotypic adaptations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5b664921e297f0cee1db715456a710
https://hal-pasteur.archives-ouvertes.fr/pasteur-04008255
https://hal-pasteur.archives-ouvertes.fr/pasteur-04008255
Autor:
Siming Ma, Sang-Goo Lee, Eun Bae Kim, Thomas J. Park, Andrei Seluanov, Vera Gorbunova, Rochelle Buffenstein, Javier Seravalli, Vadim N. Gladyshev
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1319-1326 (2015)
Trace elements are essential to all mammals, but their distribution and utilization across species and organs remains unclear. Here, we examined 18 elements in the brain, heart, kidney, and liver of 26 mammalian species and report the elemental compo
Externí odkaz:
https://doaj.org/article/67b3c61067f246ebbbc3c805f00856ac