Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Thomas J, McMurry"'
Publikováno v:
Drug Discovery Today: Technologies. 9:e33-e39
Pepducins are a class of lipidated peptide G-protein coupled receptor (GPCR) allosteric modulators that exhibit unique pharmacological properties. Because of their rational design, pepducins can potentially be used to target all members of this gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134a1820f8f5ea348939fcb4294529c6
https://doi.org/10.1016/j.ddtec.2011.07.002
https://doi.org/10.1016/j.ddtec.2011.07.002
Autor:
Richard J. Looby, Thomas J. McMurry, Manija A. Kazmi, Kenneth E. Carlson, Lynn Haggis, Jay M. Janz, Adam O'Shea, Stephen W. Hunt, Ed McBride, Pallavi Sachdev, Yong Ren, Boris Tchernychev, Thomas P. Sakmar, Qing Deng
Publikováno v:
Proceedings of the National Academy of Sciences. 107:22255-22259
The G protein-coupled receptor (GPCR), chemokine CXC-type receptor 4 (CXCR4), and its ligand, CXCL12, mediate the retention of polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Agents that di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01719d26f56bf336e4ee1c64d29aeb11
https://doi.org/10.1073/pnas.1009633108
https://doi.org/10.1073/pnas.1009633108
Autor:
Andrew Kolodziej, Thomas J. McMurry, Peter Caravan, Matthew T. Greenfield, Nair Shrikumar, Gandhali Bhole
Publikováno v:
Angewandte Chemie. 120:4996-4999
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9790ddbd2118b2be85ecd1926782be68
https://doi.org/10.1002/ange.200800563
https://doi.org/10.1002/ange.200800563
Autor:
Jaclyn M. Chasse, Qing Deng, Kirsten Overoye-Chan, Peter Caravan, Richard J. Looby, Steffi K. Koerner, Stephan G. Zech, Thomas J. McMurry, Andrew Kolodziej
Publikováno v:
Journal of the American Chemical Society. 130:6025-6039
Thrombus (blood clot) is implicated in a number of life threatening diseases, e.g., heart attack, stroke, pulmonary embolism. EP-2104R is an MRI contrast agent designed to detect thrombus by binding to the protein fibrin, present in all thrombi. EP-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8058c43392a44d69b7fedd70ee463f61
https://doi.org/10.1021/ja800834y
https://doi.org/10.1021/ja800834y
Autor:
Marga Spiller, Normand J. Cloutier, Randall B. Lauffer, Peter Caravan, Thomas J. Mcmurry, Jeffrey J. Ellison, Jaclyn M. Chasse, Claudio Luchinat, Giacomo Parigi, Sarah A. McDermid
Publikováno v:
Inorganic Chemistry. 46:6632-6639
The amphiphilic gadolinium complex MS-325 ((trisodium-{(2-(R)-[(4,4-diphenylcyclohexyl) phosphonooxymethyl] diethylenetriaminepentaacetato) (aquo)gadolinium(III)}) is a contrast agent for magnetic resonance angiography (MRA). MS-325 consists of two s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f61c279916d9ab9687d5fbb57cefac4
https://doi.org/10.1021/ic700686k
https://doi.org/10.1021/ic700686k
Autor:
Randall B. Lauffer, Thomas J. McMurry, Zhaoda Zhang, Marga Spiller, Matthew T. Greenfield, Peter Caravan
Publikováno v:
Angewandte Chemie International Edition. 44:6766-6769
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a9930a61fffda8dea3040f86056fa4
https://doi.org/10.1002/anie.200502245
https://doi.org/10.1002/anie.200502245
Autor:
Sarah A. McDermid, John C. Amedio, Matthew T. Greenfield, Arnold M. Raitsimring, Peter Caravan, Marga Spiller, Normand J. Cloutier, Randall B. Lauffer, Thomas J. McMurry, Stephen U. Dunham, Stephan G. Zech, Richard J. Looby
Publikováno v:
Chemistry - A European Journal. 11:5866-5874
The synthesis of a novel ligand, based on N-methyl-diethylenetriaminetetraacetate and containing a diphenylcyclohexyl serum albumin binding group (L1) is described and the coordination chemistry and biophysical properties of its Gd(III) complex Gd-L1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf30a66549f61dd180a265b82a46fe9
https://doi.org/10.1002/chem.200500338
https://doi.org/10.1002/chem.200500338
Autor:
Ronald M. Supkowski, William DeW. Horrocks, Richard J. Looby, Thomas J. McMurry, Randall B. Lauffer, Jeff W.M. Bulte, John C. Amedio, Sarah A. McDermid, Normand J. Cloutier, Matthew T. Greenfield, Peter Caravan, Stephen U. Dunham
Publikováno v:
Journal of the American Chemical Society. 124:3152-3162
MS-325 is a novel blood pool contrast agent for magnetic resonance imaging currently undergoing clinical trials to assess blockage in arteries. MS-325 functions by binding to human serum albumin (HSA) in plasma. Binding to HSA serves to prolong plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ada0ace5b3191a314e80bf237e2b9a9
https://doi.org/10.1021/ja017168k
https://doi.org/10.1021/ja017168k
Autor:
Alexander Nivorozhkin, Peter Caravan, Andrew Kolodziej, Matthew T. Greenfield, Randall B. Lauffer, Thomas J. McMurry
Publikováno v:
Angewandte Chemie. 113:2987-2990
Clinically relevant relaxivity enhancement of a magnetic resonance imaging (MRI) contrast agent has been achieved by using prodrug Gd3+ complexes (see picture, DTPA=diethylenetriaminepentaaceto). Enzymatic cleavage of lysine residues from the prodrug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd8e744b1c32c5fc88da68f96d0f448
https://doi.org/10.1002/1521-3757(20010803)113:15<2987::aid-ange2987>3.0.co
https://doi.org/10.1002/1521-3757(20010803)113:15<2987::aid-ange2987>3.0.co
Publikováno v:
Synthetic Communications. 26:2511-2522
A convenient synthesis of enantiomerically enriched 1-hydroxymethyl-DTPA (diethylenetriamine pentaacetic acid) penta-t-butyl esters 3 has been achieved for the preparation of chiral synthones of new paramagnetic gadolinium complexes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2a2253bc0739f13339bddf100a177be
https://doi.org/10.1080/00397919608004564
https://doi.org/10.1080/00397919608004564