Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Thomas J, McHugh"'
Autor:
Chinnakkaruppan Adaikkan, Justin Joseph, Georgios Foustoukos, Jun Wang, Denis Polygalov, Roman Boehringer, Steven J. Middleton, Arthur J. Y. Huang, Li-Huei Tsai, Thomas J. McHugh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The precise temporal coordination of neural activity is crucial for brain function. In the hippocampus, this precision is reflected in the oscillatory rhythms observed in CA1. While it is known that a balance between excitatory and inhibitor
Externí odkaz:
https://doaj.org/article/2da85b1e3b9e4d61898c937713e93409
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-8 (2023)
Abstract Social animals become stressed upon social isolation, proactively engaging in affiliative contacts among conspecifics after resocialization. We have previously reported that calcitonin receptor (Calcr) expressing neurons in the central part
Externí odkaz:
https://doaj.org/article/1f319e6156864ddc8af9a840dedea1aa
Autor:
Kansai Fukumitsu, Misato Kaneko, Teppo Maruyama, Chihiro Yoshihara, Arthur J. Huang, Thomas J. McHugh, Shigeyoshi Itohara, Minoru Tanaka, Kumi O. Kuroda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The mechanisms coordinating the sensing and seeking of social contacts are unclear. Here, the authors show that amylin-calcitonin receptor signalling in the media preoptic area mediates affiliative social behaviors in female mice.
Externí odkaz:
https://doaj.org/article/24a1ac903d5148b493993a55cbb30e82
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Bilaterally projecting CA3 inputs may be crucial for integrating the left and right CA1 during memory but this has not been directly examined. Here, the authors show that projections from bilateral CA3 play a key role in the cross-hemispheric coordin
Externí odkaz:
https://doaj.org/article/94955a31eba443dc84f83d6d0fdafa3a
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract The ability to identify specific cell–cell contact in the highly heterogeneous mammalian body is crucial to revealing precise control of the body plan and correct function. To visualize local connections, we previously developed a genetica
Externí odkaz:
https://doaj.org/article/1b91d93aa6a14636aa4ac2e4b8455e83
Autor:
Yuki Oe, Xiaowen Wang, Tommaso Patriarchi, Ayumu Konno, Katsuya Ozawa, Kazuko Yahagi, Hirokazu Hirai, Takashi Tsuboi, Tetsuya Kitaguchi, Lin Tian, Thomas J. McHugh, Hajime Hirase
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Astrocytic GPCRs activate Ca2+ and cAMP signaling pathways, however, the in vivo dynamics of the two second messengers have not been fully been characterized. The authors demonstrate distinct noradrenaline-induced astrocytic Ca2+ and cAMP dynamics du
Externí odkaz:
https://doaj.org/article/de4152a6e93445c59df4faa68661c234
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Chronic and acute stress differentially affect behavior as well as the structural integrity of the hippocampus, a key brain region involved in cognition and memory. However, it remains unclear if and how the facilitatory effects of acute stress on hi
Externí odkaz:
https://doaj.org/article/0cb6fd70520b422aad5f90035dc73267
Autor:
Nagatoki Kinoshita, Arthur J.Y. Huang, Thomas J. McHugh, Sachihiro C. Suzuki, Ichiro Masai, Il Hwan Kim, Scott H. Soderling, Atsushi Miyawaki, Tomomi Shimogori
Publikováno v:
iScience, Vol 15, Iss , Pp 28-38 (2019)
Summary: Intercellular contacts are essential for precise organ morphogenesis, function, and maintenance; however, spatiotemporal information of cell-cell contacts or adhesions remains elusive in many systems. We developed a genetically encoded fluor
Externí odkaz:
https://doaj.org/article/ae430a7a94cc4d7cbd539b1d690eac80
Publikováno v:
Neuroscience Research. 189:13-19
The place cells and well-defined oscillatory population rhythms of the rodent hippocampus have served as a powerful model system in linking cells and circuits to memory function. While the initial three decades of place cell research primarily focuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d78c07636ac0a188bf0c84fa0e61e2
https://doi.org/10.1016/j.neures.2022.12.010
https://doi.org/10.1016/j.neures.2022.12.010
Publikováno v:
Neurobiology of Stress, Vol 14, Iss , Pp 100327- (2021)
Adverse effects of chronic stress include anxiety, depression, and memory deficits. Some of these stress-induced behavioural deficits are mediated by impaired hippocampal function. Much of our current understanding about how stress affects the hippoc
Externí odkaz:
https://doaj.org/article/81392bad35614f7db8cd6fe37d628def