Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Thomas J, Maimone"'
Autor:
Claire S. Harmange Magnani, José R. Hernández-Meléndez, Dean J. Tantillo, Thomas J. Maimone
Publikováno v:
JACS Au, Vol 3, Iss 10, Pp 2883-2893 (2023)
Externí odkaz:
https://doaj.org/article/9c37f925873b48949d93d10a69d695f6
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Meroterpenes are a particularly important class of biologically active bicyclo[3.3.1]nonane-containing molecules. Here, the authors report a general strategy toward these valuable targets based on abiotic annulation/rearrangement steps resulting in a
Externí odkaz:
https://doaj.org/article/a482583341f94665b2a52960d819494a
Autor:
Sara E. Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R. Brimacombe, Mark J. Henderson, Caitlin Lynch, Tongan Zhao, Kanny K. Wan, Zina Itkin, Christopher Dillon, Min Shen, Dorian M. Cheff, Tobie D. Lee, Danielle Bougie, Ken Cheng, Nathan P. Coussens, Dorjbal Dorjsuren, Richard T. Eastman, Ruili Huang, Michael J. Iannotti, Surendra Karavadhi, Carleen Klumpp-Thomas, Jacob S. Roth, Srilatha Sakamuru, Wei Sun, Steven A. Titus, Adam Yasgar, Ya-Qin Zhang, Jinghua Zhao, Rodrigo B. Andrade, M. Kevin Brown, Noah Z. Burns, Jin K. Cha, Emily E. Mevers, Jon Clardy, Jason A. Clement, Peter A. Crooks, Gregory D. Cuny, Jake Ganor, Jesus Moreno, Lucas A. Morrill, Elias Picazo, Robert B. Susick, Neil K. Garg, Brian C. Goess, Robert B. Grossman, Chambers C. Hughes, Jeffrey N. Johnston, Madeleine M. Joullie, A. Douglas Kinghorn, David G.I. Kingston, Michael J. Krische, Ohyun Kwon, Thomas J. Maimone, Susruta Majumdar, Katherine N. Maloney, Enas Mohamed, Brian T. Murphy, Pavel Nagorny, David E. Olson, Larry E. Overman, Lauren E. Brown, John K. Snyder, John A. Porco, Fatima Rivas, Samir A. Ross, Richmond Sarpong, Indrajeet Sharma, Jared T. Shaw, Zhengren Xu, Ben Shen, Wei Shi, Corey R.J. Stephenson, Alyssa L. Verano, Derek S. Tan, Yi Tang, Richard E. Taylor, Regan J. Thomson, David A. Vosburg, Jimmy Wu, William M. Wuest, Armen Zakarian, Yufeng Zhang, Tianjing Ren, Zhong Zuo, James Inglese, Sam Michael, Anton Simeonov, Wei Zheng, Paul Shinn, Ajit Jadhav, Matthew B. Boxer, Matthew D. Hall, Menghang Xia, Rajarshi Guha, Jason M. Rohde
Publikováno v:
ACS Central Science, Vol 4, Iss 12, Pp 1727-1741 (2018)
Externí odkaz:
https://doaj.org/article/9f2975f36dd648f0b92b6e0f2b27c087
Publikováno v:
Journal of the American Chemical Society. 144:16332-16337
From both structural and functional perspectives, the large family of daphnane diterpene orthoesters (DDOs) represent a truly remarkable class of natural products. As potent lead compounds for the treatment of pain, neurodegeneration, HIV/AIDS, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9134e06f0257f59a9724d9388a4003
https://doi.org/10.1021/jacs.2c08200
https://doi.org/10.1021/jacs.2c08200
Autor:
Bridget P Belcher, Paulo A Machicao, Binqi Tong, Emily Ho, Julia Friedli, Brian So, Helen Bui, Yosuke Isobe, Thomas J Maimone, Daniel K Nomura
Publikováno v:
ChemBioChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d08a4cd2ed1565596c655088344eca46
https://doi.org/10.1002/cbic.202300111
https://doi.org/10.1002/cbic.202300111
Autor:
Flor A. Gowans, Danny Q. Thach, Yangzhi Wang, Belen E. Altamirano Poblano, Dustin Dovala, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Thomas J. Maimone, Daniel K. Nomura
SummaryOphiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anti-cancer activity. While OPA possesses multiple electrophilic moieties that can covalently react with nucleophilic amino acids on proteins, the proteome-wide targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18cdbfe8d02ec6a1bd7812b67f98c4a
https://doi.org/10.1101/2023.03.09.531918
https://doi.org/10.1101/2023.03.09.531918
Autor:
Bridget P. Belcher, Paulo A. Machicao, Binqi Tong, Emily Ho, Julia Friedli, Brian So, Helen Bui, Yosuke Isobe, Thomas J. Maimone, Daniel K. Nomura
Publikováno v:
bioRxiv
Chlorinated gymnastatin and dankastatin alkaloids derived from the fungal strainGymnascella dankaliensishave been reported to possess significant anti-cancer activity but their mode of action is unknown. These members possess electrophilic functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b21dcfcdb4248953ae2570b22c4526
https://doi.org/10.1101/2023.02.11.528139
https://doi.org/10.1101/2023.02.11.528139
Publikováno v:
Angewandte Chemie. 134
indolizidine alkaloids of unusual biosynthetic origin have recently been characterized from several species of fungi within the Pleosporaceae family. Possessing distinct polycyclic architectures with two embedded electron-rich pyrroles as well as rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbebbb21ac9f5d0e987b1f9d10f1397
https://doi.org/10.1002/ange.202209457
https://doi.org/10.1002/ange.202209457
Publikováno v:
Accounts of Chemical Research. 54:583-594
ConspectusFrom the venerable Robinson annulation to the irreplaceable Diels-Alder cycloaddition, annulation reactions have fueled the progression of the field of natural product synthesis throughout the past century. In broader terms, the ability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aba1a77b1f6b9272d965cb9865bb943
https://doi.org/10.1021/acs.accounts.0c00781
https://doi.org/10.1021/acs.accounts.0c00781
Autor:
Andre Sanchez, Thomas J. Maimone
Publikováno v:
Journal of the American Chemical Society. 144(17)
Guided by a synthetic design aimed at late-stage diversification, we report the preparation of unusual shapeshifting anions and their subsequent application to the total synthesis of the polyketide natural product ocellatusone C. Site-selective core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf0ac5854b2c505e6cbe9ba9092555d
https://pubmed.ncbi.nlm.nih.gov/35420799
https://pubmed.ncbi.nlm.nih.gov/35420799