Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thomas J, Macartney"'
Autor:
Abigail Brewer, Jin-Feng Zhao, Rotimi Fasimoye, Natalia Shpiro, Thomas J. Macartney, Nicola T. Wood, Melanie Wightman, Dario R. Alessi, Gopal P. Sapkota
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110423- (2024)
Summary: TGF-β (transforming growth factor-β) signaling is involved in a myriad of cellular processes and its dysregulation has been implicated in many human diseases, including fibrosis and cancer. TGF-β transcriptional responses are controlled b
Externí odkaz:
https://doaj.org/article/29d5d7de42d54273bca16ac8b4f72fb9
Autor:
Jin-Feng Zhao, Natalia Shpiro, Gajanan Sathe, Abigail Brewer, Thomas J. Macartney, Nicola T. Wood, Florentina Negoita, Kei Sakamoto, Gopal P. Sapkota
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110432- (2024)
Summary: Reversible phosphorylation of the transcription factor EB (TFEB) coordinates cellular responses to metabolic and other stresses. During nutrient replete and stressor-free conditions, phosphorylated TFEB is primarily localized to the cytoplas
Externí odkaz:
https://doaj.org/article/06e99590560f4d84a989e659c12d87bb
Autor:
Lorraine Glennie, Marta Codina Solà, Mar Xunclà, Gloria Aparicio Español, Elena Garcia-Arumí, Eduardo Fidel Tizzano, Nicola T. Wood, Thomas J. Macartney, Amaia Lasa-Aranzasti, Gopal P. Sapkota
Publikováno v:
Open Biology, Vol 14, Iss 7 (2024)
Palmoplantar keratoderma (PPK) is a multi-faceted skin disorder characterized by the thickening of the epidermis and abrasions on the palms and soles of the feet. Among the genetic causes, biallelic pathogenic variants in the FAM83G gene have been as
Externí odkaz:
https://doaj.org/article/f83bbced95d14422844e09e4000c188d
Autor:
Abigail Brewer, Gajanan Sathe, Billie E. Pflug, Rosemary G. Clarke, Thomas J. Macartney, Gopal P. Sapkota
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109302- (2024)
Summary: Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase. The PP2A holoenzyme complex comprises a scaffolding (A), regulatory (B), and catalytic (C) subunit, with PPP2CA being the principal catalytic subunit. The full scope of PP2A
Externí odkaz:
https://doaj.org/article/f25d696fa64648859afd184fd61b5cbd
Autor:
Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota
Publikováno v:
Wellcome Open Research, Vol 4 (2020)
Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively. We have previously
Externí odkaz:
https://doaj.org/article/6d803ddfa9804a42b43f77a667ddecfe
Autor:
Kevin Z.L. Wu, Rebecca A. Jones, Theresa Tachie-Menson, Thomas J. Macartney, Nicola T. Wood, Joby Varghese, Robert Gourlay, Renata F. Soares, James C. Smith, Gopal P. Sapkota
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively. We have previously
Externí odkaz:
https://doaj.org/article/825b99f7ce8c4131b3178e4180dfa8e2
Publikováno v:
Targeted Protein Degradation ISBN: 9780323992008
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::903bb06cf16061ca3d343e0a9d3c5a33
https://doi.org/10.1016/bs.mie.2022.08.011
https://doi.org/10.1016/bs.mie.2022.08.011
Publikováno v:
Open Biology, Vol 7, Iss 5 (2017)
Targeted proteolysis of endogenous proteins is desirable as a research toolkit and in therapeutics. CRISPR/Cas9-mediated gene knockouts are irreversible and often not feasible for many genes. Similarly, RNA interference approaches necessitate prolong
Externí odkaz:
https://doaj.org/article/dce6dc4d6a604911917352ab240c10f7
Autor:
Sascha Röth, Bill Carton, Preethi S. Sathyamurthi, Matthew Watt, Thomas J. Macartney, Kwok-Ho Chan, Albert Isidro-Llobet, Agnieszka Konopacka, Markus A. Queisser, Gopal Sapkota
Publikováno v:
SSRN Electronic Journal.
Autor:
Chandana Kondapalli, Agne Kazlauskaite, Ning Zhang, Helen I. Woodroof, David G. Campbell, Robert Gourlay, Lynn Burchell, Helen Walden, Thomas J. Macartney, Maria Deak, Axel Knebel, Dario R. Alessi, Miratul M. K. Muqit
Publikováno v:
Open Biology, Vol 2, Iss 5 (2012)
Summary Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive inherited Parkinson's disease (PD). We have exploited our recent discovery that recombinant insect PINK1 is catalytically active to test whether PINK1 directly phos
Externí odkaz:
https://doaj.org/article/a7ccab88220e49e2ad360b217db36be0