Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Thomas J, Berrodin"'
Autor:
Christopher L. Carpenter, Eldridge N. Nartey, Dominic Suarez, Elisabeth A. Minthorn, Jesus R. Medina, Louis V. LaFrance, Ralph A. Rivero, James F. Mack, Charles F. McHugh, Xinrong Tian, Dirk A. Heerding, Christina Ng Di Marco, Thomas J. Berrodin, Aishwarya Bhaskar, Biju Mangatt, William Hoi Hong Li, Brackley James, Martyr Cuthbert, Lorena A. Kallal, Michael Butticello, Jacob Rubin
Publikováno v:
Journal of Medicinal Chemistry. 64:16056-16087
Elevated expression of the c-MYC oncogene is one of the most common abnormalities in human cancers. Unfortunately, efforts to identify pharmacological inhibitors that directly target MYC have not yet yielded a drug-like molecule due to the lack of an
Autor:
Xinrong Tian, Dominic Suarez, Douglas Thomson, William Li, Elizabeth A. King, Louis LaFrance, Jeffrey Boehm, Linda Barton, Christina Di Marco, Cuthbert Martyr, Reema Thalji, Jesus Medina, Steven Knight, Dirk Heerding, Enoch Gao, Eldridge Nartey, Ted Cecconie, Christopher Nixon, Guofeng Zhang, Thomas J. Berrodin, Christopher Phelps, Amish Patel, Xiaopeng Bai, Ken Lind, Ninad Prabhu, Jeffrey Messer, Zhengrong Zhu, Lisa Shewchuk, Rob Reid, Alan P. Graves, Charles McHugh, Biju Mangatt
Publikováno v:
Journal of medicinal chemistry. 65(21)
E1A binding protein (p300) and CREB binding protein (CBP) are two highly homologous and multidomain histone acetyltransferases. These two proteins are involved in many cellular processes by acting as coactivators of a large number of transcription fa
Autor:
Elaine M. Quinet, Michael D. Basso, Anita R. Halpern, David W. Yates, Robert J. Steffan, Valerie Clerin, Christine Resmini, James C. Keith, Thomas J. Berrodin, Irene Feingold, Wenyan Zhong, Helen B. Hartman, Mark J. Evans, Stephen J. Gardell, Elizabeth DiBlasio-Smith, William M. Mounts, Edward R. LaVallie, Jay Wrobel, Ponnal Nambi, George P. Vlasuk
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 12, Pp 2358-2370 (2009)
Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in several cellular functions but most notably cholesterol homeostasis encompassing cholesterol transport, catabolism, and abso
Externí odkaz:
https://doaj.org/article/ec0b71a6e2bf4790a3a5a3256e00f5d7
Autor:
Jesús R, Medina, Xinrong, Tian, William H, Li, Dominic, Suarez, James F, Mack, Louis, LaFrance, Cuthbert, Martyr, James, Brackley, Christina, Di Marco, Ralph, Rivero, Dirk A, Heerding, Charles, McHugh, Elisabeth, Minthorn, Aishwarya, Bhaskar, Jacob, Rubin, Michael, Butticello, Christopher, Carpenter, Eldridge N, Nartey, Thomas J, Berrodin, Lorena A, Kallal, Biju, Mangatt
Publikováno v:
Journal of medicinal chemistry. 64(21)
Elevated expression of the
High-Throughput Screening and Triage Assays Identify Small Molecules Targeting c-MYC in Cancer Cells
Autor:
Jon-Paul Jaworski, Lisa A. Payne, Anna Waszkiewicz, Biju Mangatt, Anthony J. Jurewicz, Lorena A. Kallal, Jesus R. Medina, Pat Brady, Xin Zeng, Thomas J. Berrodin, Carolyn Doepner-Buser, Anthony Della Pietra
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(2)
While c-MYC is well established as a proto-oncogene, its structure and function as a transcription factor have made c-MYC a difficult therapeutic target. To identify small-molecule inhibitors targeting c-MYC for anticancer therapy, we designed a high
Autor:
Thomas J. Berrodin, Leonard P. Freedman, Elaine Quinet, Qi Shen, Matthew R. Yudt, Sunil Nagpal
Publikováno v:
Molecular Pharmacology. 78:1046-1058
The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor superfamily that function as key transcriptional regulators of a number of biological processes, including cholesterol homeostasis, lipid metabolism, and keratinocyte differe
Abstract 2919: Discovery of small-molecule compounds targeting c-MYC using a novel cell-based screen
Autor:
Stuart Paul Romeril, Gopinath Ganji, Dirk A. Heerding, George P. Livi, Anna Rutkowska-Klute, William Hoi Hong Li, James F. Mack, Elisabeth A. Minthorn, Derrick W. Meinhold, Carolyn A. Buser, Jesus R. Medina, Lorena A. Kallal, Shanker K. Sundaram, Biju Mangatt, Anthony Della Pietra, Sonja Ghidelli-Disse, Anna Waszkiewicz, Jon-Paul Jaworski, Thomas J. Berrodin, Rakesh Kumar, Wendy S. Halsey, Christian S. Sherk, Gerard Drewes
Publikováno v:
Cancer Research. 78:2919-2919
Elevated expression of the c-MYC oncogene (either due to gene amplification, translocation, abnormality in upstream signaling pathways and/or protein stabilization) is one of the most common abnormalities in human cancers. Efforts to identify direct
Autor:
Baihua Hu, Elaine Quinet, Irene Feingold, Igor Goljer, Thomas J. Berrodin, Mark J. Evans, James W Jetter, Jay Wrobel, Rayomand J. Unwalla, Michael D Basso, Annika Goos Nilsson, Anna Wilhelmsson
Publikováno v:
Journal of Medicinal Chemistry. 53:3296-3304
A series of phenyl sulfone substituted quinoxaline were prepared and the lead compound 13 (WYE-672) was shown to be a tissue selective LXR Agonist. Compound 13 demonstrated partial agonism for LXRbeta in kidney HEK-293 cells but did not activate Gal4
Autor:
Richard C. Winneker, Thomas J. Berrodin, Nilsa Graciani, Zhiming Zhang, Matthew R. Yudt, Sunil Nagpal, John A. Butera, Scott A. Jelinsky
Publikováno v:
Biochemical Pharmacology. 77:204-215
Progesterone receptor (PR) modulators are used in contraception and post-menopausal hormone therapy, and are under clinical development for reproductive disorders such as uterine fibroids and endometriosis. Development of tissue selective PR modulato
Autor:
Richard C. Winneker, Puwen Zhang, Terefenko Eugene Anthony, Zhiming Zhang, Andrew Fensome, Jeffrey I. Cohen, Ray Unwalla, Jay E. Wrobel, Matthew R. Yudt, Thomas J. Berrodin, Jeffrey Curtis Kern
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:6589-6600
Novel 7-aryl benzo[1,4]oxazepin-2-ones were synthesized and evaluated as non-steroidal progesterone receptor (PR) modulators. The structure activity relationship of 7-aryl benzo[1,4]oxazepinones was examined using the T47D cell alkaline phosphatase a