Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Thomas Iskratsch"'
Autor:
Pamela Swiatlowska, William Tipping, Emilie Marhuenda, Paolo Severi, Vitalay Fomin, Zhisheng Yang, Qingzhong Xiao, Duncan Graham, Cathy Shanahan, Thomas Iskratsch
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract Arterial Vascular smooth muscle cells (VSMCs) play a central role in the onset and progression of atherosclerosis. Upon exposure to pathological stimuli, they can take on alternative phenotypes that, among others, have been described as macr
Externí odkaz:
https://doaj.org/article/7c523d4a9e724db284fa32309d7af3b7
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
A review of the function of the Dystrophic Glycoprotein Complex (DGC) in mechanosignaling provides an overview of the various components of DGC and potential mechanopathogenic mechanisms, particularly as they relate to muscular dystrophy.
Externí odkaz:
https://doaj.org/article/09c0e0fa90e846409acd42eaa213e997
Autor:
Emilie Marhuenda, Christine Fabre, Cunjie Zhang, Martà Martin-Fernandez, Thomas Iskratsch, Ali Saleh, Luc Bauchet, Julien Cambedouzou, Jean-Philippe Hugnot, Hugues Duffau, James W. Dennis, David Cornu, Norbert Bakalara
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-14 (2021)
Abstract Background Glioblastomas stem-like cells (GSCs) by invading the brain parenchyma, remains after resection and radiotherapy and the tumoral microenvironment become stiffer. GSC invasion is reported as stiffness sensitive and associated with a
Externí odkaz:
https://doaj.org/article/8584520dc28a401fbfe7d716634ea18d
Autor:
Jacob A Ross, Nathaly Arcos-Villacis, Edmund Battey, Cornelis Boogerd, Constanza Avalos Orellana, Emilie Marhuenda, Pamela Swiatlowska, Didier Hodzic, Fabrice Prin, Tim Mohun, Norman Catibog, Olga Tapia, Larry Gerace, Thomas Iskratsch, Ajay M Shah, Matthew J Stroud
Publikováno v:
Cardiovascular Research.
Aims Nuclear envelope integrity is essential for the compartmentalization of the nucleus and cytoplasm. Importantly, mutations in genes encoding nuclear envelope (NE) and associated proteins are the second highest cause of familial dilated cardiomyop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb8b340c57ca8940e08444cacc4c7fc
https://doi.org/10.1093/cvr/cvad061
https://doi.org/10.1093/cvr/cvad061
Autor:
Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa
Supplementary Figure 1 and 2. Generation and Characterisation of ECCre+;FAKY397F/Y397F and ECCre+;FAKY861F/Y861F mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5282133926484d2f37715e73d3989246
https://doi.org/10.1158/0008-5472.22422237.v1
https://doi.org/10.1158/0008-5472.22422237.v1
Autor:
Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa
Supplementary Figure 6. Knocking down Ang-2 in B16F0s cells ablates angiogenic response in ECCre+;FAKY861F/Y861F mice in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ed9c4100bd25c2f70043fe68231339
https://doi.org/10.1158/0008-5472.22422225.v1
https://doi.org/10.1158/0008-5472.22422225.v1
Autor:
Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa
Expression of focal adhesion kinase (FAK) in endothelial cells (EC) is essential for angiogenesis, but how FAK phosphorylation at tyrosine-(Y)397 and Y861 regulate tumor angiogenesis in vivo is unknown. Here, we show that tumor growth and angiogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eee9a002e76a2569618268b1a0af530
https://doi.org/10.1158/0008-5472.c.6511158.v1
https://doi.org/10.1158/0008-5472.c.6511158.v1
Autor:
Pamela Swiatlowska, Thomas Iskratsch
Publikováno v:
Cardiovascular Drugs and Therapy.
The local mechanical microenvironment impacts on the cell behavior. In the cardiovascular system, cells in both the heart and the vessels are exposed to continuous blood flow, blood pressure, stretching forces, and changing extracellular matrix stiff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83017d4f69179f1882b833794cfda335
https://doi.org/10.1007/s10557-022-07422-z
https://doi.org/10.1007/s10557-022-07422-z
Autor:
Pamela Swiatlowska, Thomas Iskratsch
Publikováno v:
Biophysical Reviews
Cardiomyocytes generate force for the contraction of the heart to pump blood into the lungs and body. At the same time, they are exquisitely tuned to the mechanical environment and react to e.g. changes in cell and extracellular matrix stiffness or a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1672c49d9f6f0fc6b628a6254662508f
https://doi.org/10.1007/s12551-021-00837-2
https://doi.org/10.1007/s12551-021-00837-2
Autor:
Rachel Jacques, Bo Zhou, Emilie Marhuenda, Jon Gorecki, Anirban Das, Thomas Iskratsch, Steffi Krause
Accurate monitoring of cardiomyocyte action potentials (APs) is essential to understand disease propagation and for trials of novel therapeutics. Patch clamp techniques offer ‘gold standard’ measurements in this field, but are notoriously difficu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92608fda81e4b8b4d2e7fa36e63193a3
https://doi.org/10.1101/2022.09.05.506608
https://doi.org/10.1101/2022.09.05.506608