Výsledky vyhledávání - "Thomas I. Peng Soh"

Longitudinal monitoring reveals dynamic changes in circulating tumor cells (CTCs) and CTC-associated miRNAs in response to chemotherapy in metastatic colorectal cancer patients

Autor: Karen Tan, Michael Vito Martin Blanco, Sai Mun Leong, Zizheng Kee, Patrick Vincent Caramat, Thomas I-Peng Soh, Wei Peng Yong, Wai Kit Cheong, James Teo, Evelyn Siew-Chuan Koay, Angela Pang

Publikováno v: Cancer Letters. 423:1-8

We evaluated the changes in CTC count and CTC-associated miRNAs during the course of chemotherapy in patients with metastatic colorectal cancer. Blood samples were collected from 9 metastatic colorectal cancer patients prior to chemotherapy and at ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f06ac012a85b8cf865500352eca0a1c
https://doi.org/10.1016/j.canlet.2018.02.039

Zobrazit plný text záznamu

Conversion Surgery Post-Intraperitoneal Paclitaxel and Systemic Chemotherapy for Gastric Cancer Carcinomatosis Peritonei. Are We Ready?

Autor: Cheng Ean Chee, Rachel Yap, Wei Peng Yong, Thomas I. Peng Soh, Dexter Yak Seng Chan, Jimmy Bok Yan So, Asim Shabbir, Nicholas Syn, Min En Nga, Janelle Niam Sin Phua

Publikováno v: Journal of Gastrointestinal Surgery. 21:425-433

Peritoneal metastasis is common in gastric cancer. It is difficult to treat and carries a poor prognosis. Intraperitoneal (IP) delivery of chemotherapy can attain a higher drug exposure in the peritoneal cavity but with reduced systemic toxicity. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bdd6bea97d8f15d0276ed778980286
https://doi.org/10.1007/s11605-016-3336-3

Zobrazit plný text záznamu

Improving Wait Times for Elective Chemotherapy Through Pre-Preparation: A Quality-Improvement Project at the National University Cancer Institute of Singapore

Autor: Zarinah Hairom, Chee Seng Tan, Siew Eng Lim, Boon Cher Goh, Yi Siew Tan, Yuet Peng Wong, Thomas I Peng Soh, Yao Yao, Mariana Ibrahim, Siew Woon Lim

Publikováno v: Journal of Oncology Practice. 11:e89-e94

Cancer treatment occurs predominantly in the outpatient setting. Long wait times for chemotherapy lead to increased dissatisfaction, inefficient use of chemotherapy chairs, and compromised safety when delays result in treatment beyond operation hours

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746007a0fd2f746afc8b33402d9ea96b
https://doi.org/10.1200/jop.2014.000356

Zobrazit plný text záznamu

Correlation of aldo-ketoreductase (AKR) 1C3 genetic variant with doxorubicin pharmacodynamics in Asian breast cancer patients

Autor: Soo-Chin Lee, Andrea Li Ann Wong, Fan Lu, How Sung Lee, Thomas I Peng Soh, Richie Soong, Pei Jye Voon, Boon Cher Goh, Nur Sabrina Sapari, Hui Ling Yap, Cho-Yee-Thu Ma

Publikováno v: British Journal of Clinical Pharmacology. 75:1497-1505

Aims Aldo-ketoreductases have been implicated in the metabolism of doxorubicin. We sought to assess the influence of AKR1C3 genetic variants on doxorubicin metabolism. Methods We sequenced AKR1C3 exon 5 and genotyped seven functional single nucleotid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f09917e08bbf57564fe189341360064
https://doi.org/10.1111/bcp.12021

Zobrazit plný text záznamu

Targeted Therapy at the End of Life in Advanced Cancer Patients

Autor: Noreen Chan, Siew Woon Lim, Yi-Ching Yuen, Alvin Wong, Thomas I Peng Soh, Catherine Teo

Publikováno v: Journal of Palliative Medicine. 15:991-997

We describe the use of systemic therapy in advanced cancer patients admitted to an acute care hospital, with a focus on targeted therapy. We aim to spotlight the utilization of targeted agents in the last months of life.Adult patients (N=252) with ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340c497e54b33a4691b36023ccb11520
https://doi.org/10.1089/jpm.2012.0050

Zobrazit plný text záznamu

Phenotyping of UGT1A1 Activity Using Raltegravir Predicts Pharmacokinetics and Toxicity of Irinotecan in FOLFIRI

Autor: Soo-Chin Lee, Boon Cher Goh, Pei F. Cheong, Wei Peng Yong, Nur Sabrina Sapari, Lu Fan, Andrea Li Ann Wong, Kim-Hor Hee, Thomas I Peng Soh, Ross A. Soo, Kok-Yong Seng, Lawrence S. Lee, Richie Soong, Lingzhi Wang

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0147681 (2016)

BACKGROUND:Irinotecan toxicity correlates with UGT1A1 activity. We explored whether phenotyping UGT1A1 using a probe approach works better than current genotyping methods. METHODS:Twenty-four Asian cancer patients received irinotecan as part of the F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e6a0b30f1f68e3ef1d586a3207d61d
https://pubmed.ncbi.nlm.nih.gov/26808671

Zobrazit plný text záznamu

Recent progress and clinical importance on pharmacogenetics in cancer therapy

Autor: Federico Innocenti, Wei Peng Yong, Thomas I Peng Soh

Recent advances have provided unprecedented opportunities to identify prognostic and predictive markers of efficacy of cancer therapy. Genetic markers can be used to exclude patients who will not benefit from therapy, exclude patients at high risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70ad645f4cdd7d404b8cc59490f057b
https://europepmc.org/articles/PMC3858908/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání