Age-related differences of cerebellar cortex and nuclei: MRI findings in healthy controls and its application to spinocerebellar ataxia (SCA6) patients

Autor: Dominik Jäschke, Katharina M. Steiner, Dae-In Chang, Jens Claaßen, Ellen Uslar, Andreas Thieme, Marcus Gerwig, Viktor Pfaffenrot, Thomas Hulst, Alexander Gussew, Stefan Maderwald, Sophia L. Göricke, Martina Minnerop, Mark E. Ladd, Jürgen R. Reichenbach, Dagmar Timmann, Andreas Deistung

Publikováno v: NeuroImage, Vol 270, Iss , Pp 119950- (2023)

Understanding cerebellar alterations due to healthy aging provides a reference point against which pathological findings in late-onset disease, for example spinocerebellar ataxia type 6 (SCA6), can be contrasted. In the present study, we investigated

Externí odkaz: https://doaj.org/article/07bcb80147d244cb9d7ef51f37d0b8b5

Quantitative susceptibility mapping reveals alterations of dentate nuclei in common types of degenerative cerebellar ataxias

Autor: Andreas Deistung, Dominik Jäschke, Rossitza Draganova, Viktor Pfaffenrot, Thomas Hulst, Katharina M. Steiner, Andreas Thieme, Ilaria A. Giordano, Thomas Klockgether, Sinem Tunc, Alexander Münchau, Martina Minnerop, Sophia L. Göricke, Jürgen R. Reichenbach, Dagmar Timmann

Publikováno v: Brain communications 4(1), fcab306 (2022). doi:10.1093/braincomms/fcab306

The cerebellar nuclei are a brain region with high iron content. Surprisingly, little is known about iron content in the cerebellar nuclei and its possible contribution to pathology in cerebellar ataxias, with the only exception of Friedreich’s ata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2b8d2ca33e04e24f496c6a9ba12cfd
https://pubmed.ncbi.nlm.nih.gov/35178517

Can we improve slow learning in cerebellar patients?

Autor: Thomas Hulst, Sophia L. Goericke, Dagmar Timmann, A. Mamlins, Dae-In Chang, Opher Donchin, Maarten A. Frens

We tested whether training paradigms targeting slow learning alleviate motor learning deficits of cerebellar patients compared to matched controls using four visuomotor tasks: standard, gradual, overlearning and long intertrial interval. We measured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed5989770b6a00f4292397c4bb5bd9d
https://doi.org/10.1101/2020.07.03.185959

Long-term effects of cerebellar anodal transcranial direct current stimulation (tDCS) on the acquisition and extinction of conditioned eyeblink responses

Autor: Dagmar Timmann, Marcus Gerwig, Giorgi Batsikadze, Thomas M. Ernst, Otilia Kimpel, Michael A. Nitsche, Thomas Hulst

Publikováno v: Scientific reports, 10:22434
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, 10(1):22434. Nature Publishing Group
Scientific Reports

Cerebellar transcranial direct current stimulation (tDCS) has been reported to enhance the acquisition of conditioned eyeblink responses (CR), a form of associative motor learning. The aim of the present study was to determine possible long-term effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0bce8cd8ff31008dc86a563c90ad5c
https://repository.publisso.de/resource/frl:6428827

Behavioural and neural basis of anomalous motor learning in children with autism

Autor: Mollie K. Marko, Deana Crocetti, Reza Shadmehr, Opher Donchin, Stewart H. Mostofsky, Thomas Hulst

Publikováno v: Brain, 138, 784-797. Oxford University Press

Autism spectrum disorder is a developmental disorder characterized by deficits in social and communication skills and repetitive and stereotyped interests and behaviours. Although not part of the diagnostic criteria, individuals with autism experienc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17ff845880943bef66203b42d0cd800
https://doi.org/10.1093/brain/awu394