Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thomas Hollenbeck"'
Publikováno v:
In Plastic Surgery Edition: Fifth Edition. 2024:311-326
Autor:
John Isbell, Ashley Chong, Patrick White, Thomas Hollenbeck, Lucas Westling, Stefan J. Thibodeaux
Publikováno v:
Journal of pharmaceutical sciences. 109(11)
In vitro absorption, distribution, metabolism and elimination (ADME) assays are widely used for profiling compounds in pharmaceutical drug discovery programs. Many compounds are screened in metabolic stability assays, using liver microsomes as a mode
Autor:
W. Perry Gordon, Tove Tuntland, Shelly Meeusen, Leah Clemmer, Sara Da Ros, Laura Bordone, Robert Hill, Thomas Hollenbeck, John W. Fathman, Kenneth Ng, Sheryll Espinola, Xiaohui He, Bo Liu, John Nelson, Maya Iskandar, Xue-Feng Zhu, Vân Nguyen-Tran, Andreas Kreusch, David C.S. Huang, Songchun Jiang, Yong Jia, Badry Bursulaya, Janine E. Baaten, Jian Shi, Mu-Yun Gao, Tao Jiang, Barun Okram, Glen Spraggon, Pierre-Yves Michellys, Hong Liu
Publikováno v:
ACS Medicinal Chemistry Letters. 8:1048-1053
NOD2 (nucleotide-binding oligomerization domain-containing protein 2) is an internal pattern recognition receptor that recognizes bacterial peptidoglycan and stimulates host immune responses. Dysfunction of NOD2 pathway has been associated with a num
Autor:
Chek Shik Lim, Advait Nagle, Chun Li, Clemens H. M. Kocken, Pranab Mishra, Tove Tuntland, Wei Lin Sandra Sim, Rachel Borboa, Case W. McNamara, Seh Yong Leong, Nobutaka Kato, Christophe Bodenreider, Anne-Marie Zeeman, Prasuna Guntapalli, Kelli Kuhen, Thomas Hollenbeck, Thierry T. Diagana, Arnab K. Chatterjee, Elizabeth A. Winzeler, Liying Jocelyn Tan, Jonathan Chang, Siti Nurdiana Abas, Paul W. Smith, Bryan K. S. Yeung, Yong Cheng Tan, David C. Tully, Jason Roland, Suresh B. Lakshminarayana, Bin Zou, Kerstin Gagaring
Publikováno v:
ACS Medicinal Chemistry Letters. 5:947-950
Imidazopyridine 1 was identified from a phenotypic screen against P. falciparum (Pf) blood stages and subsequently optimized for activity on liver-stage schizonts of the rodent parasite P. yoelii (Py) as well as hypnozoites of the simian parasite P.
Autor:
Xuena Lin, Kelli Kuhen, Tao Wu, Elizabeth A. Winzeler, Christoph Fischli, Chun Li, Kerstin Gagaring, Jared Ek, Tiffany Chuan, Suresh B. Lakshminarayana, Rachel Borboa, Thomas Hollenbeck, Arnab K. Chatterjee, Fenghua Liu, Thierry T. Diagana, Richard Glynne, Caroline Francek, Reto Brun, Advait Nagle, John Isbell, Bo Liu, Christopher Caldwell, David C. Tully, David Plouffe, Tove Tuntland, Philip B. Alper, Suzanne Skolnik, Jonathan Chang, Jianling Wang, Matthias Rottmann, Zhong Chen
Publikováno v:
Journal of Medicinal Chemistry
On the basis of the initial success of optimization of a novel series of imidazolopiperazines, a second generation of compounds involving changes in the core piperazine ring was synthesized to improve antimalarial properties. These changes were carri
Autor:
Thomas Hollenbeck, Christine Tumanut, Donald S. Karanewsky, Robert Epple, Michael J. Roberts, Hong Liu, Michael Hornsby, Glen Spraggon, David H. Woodmansee, Brian T. Masick, Tove Tuntland, Jonathan Chang, David C. Tully, Jun Li, Jennifer A. Williams, Jennifer L. Harris, Phil B. Alper, Perry Gordon, Arnab K. Chatterjee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5112-5117
The synthesis and structure-activity relationship of a series of arylaminoethyl amide cathepsin S inhibitors are reported. Optimization of P3 and P2 groups to improve overall physicochemical properties resulted in significant improvements in oral bio
Autor:
Monique Vallee, Robert Purdy, Lee R. Hagey, Gary Siuzdak, Kelly Chatman, Thomas Hollenbeck, Friedbert Weiss
Publikováno v:
Analytical Chemistry. 71:2358-2363
Nanoelectrospray ionization (nanoESI) mass spectrometry was performed on naturally occurring steroid sulfates and unconjugated steroids derivatized to their sulfate esters using precursor ion monitoring. Initially, an extraction method was developed
Autor:
Chun Li, Véronique Dartois, Jeanette Wu, Suzanne Skolnik, Thierry T. Diagana, Thomas H. Keller, Advait Nagle, David Plouffe, Maria Tan, Matthias Rottmann, Xuena Lin, Arnab K. Chatterjee, Jonathan Chang, Elizabeth A. Winzeler, Suresh B. Lakshminarayana, Fenghua Liu, Kerstin Gagaring, John Isbell, Tao Wu, William Tan, Christopher Caldwell, Richard Glynne, Zhong Chen, Christoph Fischli, David C. Tully, Anne Goh, Tove Tuntland, Min Low Kang, Nicole Y. Ye, Jared Ek, Reto Brun, Hui Qing Ang, Rachel Borboa, Thomas Hollenbeck, Jianling Wang, Peiting Zeng, Kelli L. Kuhen, Caroline Francek
Publikováno v:
Journal of medicinal chemistry. 54(14)
[Image: see text] Starting from a hit series from a GNF compound library collection and based on a cell-based proliferation assay of Plasmodium falciparum, a novel imidazolopiperazine scaffold was optimized. SAR for this series of compounds is discus
Autor:
Van Nguyen-Tran, Sarah P. Gerber, S. Renee Commerford, Peter McNamara, Chad Schwartzkopf, Beatriz N. Dardik, Yu Alice Chen, Jesper Gromada, Frederique Chaperon, Hong Liu, Sandra Teixeira, Xiaohui He, H. Martin Seidel, Anneliese L. Jaton, Thomas Hollenbeck, Laura H. Jacobson
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 384(6)
Pharmacologic antagonism of cannabinoid 1 receptors (CB1 receptors) in the central nervous system (CNS) suppresses food intake, promotes weight loss, and improves the metabolic profile. Since the CB1 receptor is expressed both in the CNS and in perip
Autor:
Tove Tuntland, Thomas Hollenbeck, Jennifer L. Harris, Guo Jianhua, Ross Russo, Hong Liu, Jun Li, Arnab K. Chatterjee, Perry Gordon, Jonathan Chang, David C. Tully, Christine Tumanut, Robert Epple, Jennifer A. Williams, Michael J. Roberts
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(10)
Peptidic, non-covalent inhibitors of lysosomal cysteine protease cathepsin S (1 and 2) were investigated due to low oral bioavailability, leading to an improved series of peptidomimetic inhibitors. Utilizing phenyl succinamides as the P2 residue incr