Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Thomas Holcomb"'
Autor:
Leonard D. Goldstein, James Lee, Florian Gnad, Christiaan Klijn, Annalisa Schaub, Jens Reeder, Anneleen Daemen, Corey E. Bakalarski, Thomas Holcomb, David S. Shames, Ryan J. Hartmaier, Juliann Chmielecki, Somasekar Seshagiri, Robert Gentleman, David Stokoe
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2605-2617 (2016)
The Nrf2 pathway is frequently activated in human cancers through mutations in Nrf2 or its negative regulator KEAP1. Using a cell-line-derived gene signature for Nrf2 pathway activation, we found that some tumors show high Nrf2 activity in the absenc
Externí odkaz:
https://doaj.org/article/e594afbe1e7541f5bfa7c4dffdee5106
Autor:
Zineb Mounir, Mark R. Lackner, Shih-Min A. Huang, Yannick Waumans, Mark Kockx, Koen M. Marien, Sarah Lynagh, Paul R. McAdam, Max Bylesjo, Adrian R. Carr, Daniel L. Halligan, Sanjeev Mariathasan, Edward E. Kadel, Kobe C. Yuen, Thomas Holcomb, Shrividhya Srinivasan, Joseph Castillo, Marie-Claire Wagle
supplementary tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35073d94791ff25b6df92ad645e456c1
https://doi.org/10.1158/2326-6066.22543155.v1
https://doi.org/10.1158/2326-6066.22543155.v1
Supplementary Fig 1 from Tumor Fusion Burden as a Hallmark of Immune Infiltration in Prostate Cancer
Autor:
Zineb Mounir, Mark R. Lackner, Shih-Min A. Huang, Yannick Waumans, Mark Kockx, Koen M. Marien, Sarah Lynagh, Paul R. McAdam, Max Bylesjo, Adrian R. Carr, Daniel L. Halligan, Sanjeev Mariathasan, Edward E. Kadel, Kobe C. Yuen, Thomas Holcomb, Shrividhya Srinivasan, Joseph Castillo, Marie-Claire Wagle
TMB, TFB and CRPC scores across individual samples and disease stages and crosscorrelation analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9124389488a6abd15abccd6bbf624d28
https://doi.org/10.1158/2326-6066.22543161.v1
https://doi.org/10.1158/2326-6066.22543161.v1
Autor:
Zineb Mounir, Mark R. Lackner, Shih-Min A. Huang, Yannick Waumans, Mark Kockx, Koen M. Marien, Sarah Lynagh, Paul R. McAdam, Max Bylesjo, Adrian R. Carr, Daniel L. Halligan, Sanjeev Mariathasan, Edward E. Kadel, Kobe C. Yuen, Thomas Holcomb, Shrividhya Srinivasan, Joseph Castillo, Marie-Claire Wagle
Prostate cancer is the second leading cause of cancer-related death in men. Despite having a relatively lower tumor mutational burden than most tumor types, multiple gene fusions such as TMPRSS2:ERG have been characterized and linked to more aggressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e25bc093bffce3f195eb2bcc044f33
https://doi.org/10.1158/2326-6066.c.6550161.v1
https://doi.org/10.1158/2326-6066.c.6550161.v1
Autor:
Lisa D. Belmont, Hartmut Koeppen, Richard Bourgon, Thomas O'Brien, Robert L. Yauch, Xiaorong Liang, Bianca Liederer, Peter M. Haverty, Thinh Pham, Yang Xiao, Dane Mohl, Pan Du, Thomas Holcomb, Kimberly Walter, Kristi Elkins, David S. Shames
Purpose: We sought to identify predictive biomarkers for a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor.Experimental Design: We use a NAMPT inhibitor, GNE-617, to evaluate nicotinic acid rescue status in a panel of more than 400 can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e84aa7961f32a2031d250e784a4c317
https://doi.org/10.1158/1078-0432.c.6520628.v1
https://doi.org/10.1158/1078-0432.c.6520628.v1
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Supplementary figure 3 shows H3K27 acetylation ChIPseq QC analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477ddd9560eda30f5c026406d5682a9e
https://doi.org/10.1158/0008-5472.22421168.v1
https://doi.org/10.1158/0008-5472.22421168.v1
Autor:
Zineb Mounir, Mark R. Lackner, Jennifer M. Giltnane, Vicki Plaks, Shih-Min A. Huang, Steven Magnuson, F. Anthony Romero, Andrew Glibicky, Thomas Holcomb, Somayeh S. Tarighat, Matthew P. Stokes, Wendell Jones, Katherine E. Hutchinson, Bonnie Liu, Jeffrey Eastham-Anderson, Melissa Gonzalez Edick, Sangeeta Jayakar, Marie-Claire Wagle, Ron McCord, Shrividhya Srinivasan, Christopher Lowe, Esther Wu, Joseph Castillo
Regulatory T cells (Treg) are immunosuppressive and negatively impact response to cancer immunotherapies. CREB-binding protein (CBP) and p300 are closely related acetyltransferases and transcriptional coactivators. Here, we evaluate the mechanisms by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00dfda38464bfe249a1e9c6500c6cdae
https://doi.org/10.1158/0008-5472.c.6510854.v1
https://doi.org/10.1158/0008-5472.c.6510854.v1
Autor:
Lisa D. Belmont, Hartmut Koeppen, Richard Bourgon, Thomas O'Brien, Robert L. Yauch, Xiaorong Liang, Bianca Liederer, Peter M. Haverty, Thinh Pham, Yang Xiao, Dane Mohl, Pan Du, Thomas Holcomb, Kimberly Walter, Kristi Elkins, David S. Shames
PDF file 122K, A) Chemical structure of GNE-617, B) cellular NAD and ATP levels in H522 cells after exposure to 4nM GNE-617, C) correlation of NAPRT1 mRNA and protein (n=32, spearman r= 0.88, p,0.0001)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3078920a930d4fcc697360aeedd937c0
https://doi.org/10.1158/1078-0432.22446035
https://doi.org/10.1158/1078-0432.22446035
Autor:
David S. Shames, Robert L. Yauch, Richard Bourgon, Lukas C. Amler, Garret M. Hampton, Somasekar Seshagiri, Zora Modrusan, Howard Stern, Ling Huw, Robert Soriano, Leonardo Iniguez, Nithya Kartha, Marie Evangelista, Pan Du, Tom Januario, Thomas Holcomb, Kim Walter
Purpose: Non–small cell lung cancers (NSCLC) comprise multiple distinct biologic groups with different prognoses. For example, patients with epithelial-like tumors have a better prognosis and exhibit greater sensitivity to inhibitors of the epiderm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14ce41ba405cf8dca77e1264fa33a7c8
https://doi.org/10.1158/1078-0432.c.6520001
https://doi.org/10.1158/1078-0432.c.6520001
Autor:
David S. Shames, Robert L. Yauch, Richard Bourgon, Lukas C. Amler, Garret M. Hampton, Somasekar Seshagiri, Zora Modrusan, Howard Stern, Ling Huw, Robert Soriano, Leonardo Iniguez, Nithya Kartha, Marie Evangelista, Pan Du, Tom Januario, Thomas Holcomb, Kim Walter
PDF file - 1.8MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9475f73ba3c38236adf386ed5b9ec970
https://doi.org/10.1158/1078-0432.22443884.v1
https://doi.org/10.1158/1078-0432.22443884.v1