Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Thomas Holbro"'
Autor:
Emma Ispasanie, Lukas Muri, Marc Schmid, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSeveral diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3. However, complement is required for serum bactericidal activity (SBA) against encapsulated Gra
Externí odkaz:
https://doaj.org/article/98f0748c5c004296ac5b23564869901e
Autor:
Lukas Muri, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke, Emma Ispasanie
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Defense against Haemophilus influenzae type b (Hib) is dependent on antibodies and complement, which mediate both serum bactericidal activity (SBA) and opsonophagocytosis. Here we evaluated the influence of capsule-specific antibodies and complement
Externí odkaz:
https://doaj.org/article/4b7cdba275ec434c86e39c3f02799783
Autor:
Emma Ispasanie, Lukas Muri, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Dysregulation of complement activation causes a number of diseases, including paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. These conditions can be treated with monoclonal antibodies (mAbs) that bind to the complement co
Externí odkaz:
https://doaj.org/article/738a9b24a2a8447095dcef2b7ca6d73f
Autor:
Lukas Muri, Emma Ispasanie, Anna Schubart, Christine Thorburn, Natasa Zamurovic, Thomas Holbro, Michael Kammüller, Gerd Pluschke
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed killing of pneumococci by human blood leukocytes collected from vaccine-naïve and PCV13-vaccin
Externí odkaz:
https://doaj.org/article/b9295bf56f22447e8d94a836689a5a13
Autor:
Johannes Grand, Kristina Miger, Ahmad Sajadieh, Lars Køber, Christian Torp‐Pedersen, Georg Ertl, José López‐Sendón, Aldo Pietro Maggioni, John R. Teerlink, Naoki Sato, Claudio Gimpelewicz, Marco Metra, Thomas Holbro, Olav W. Nielsen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
BACKGROUND In acute heart failure (AHF), systolic blood pressure (SBP) is an important clinical variable. This study assessed the association between SBP and short‐term and long‐term outcomes in a large cohort of patients with AHF. METHODS AND RE
Externí odkaz:
https://doaj.org/article/636a3e8061e2406bb8f59516c46630bc
Autor:
Thomas Holbro, Javed Butler, Peter E. Carson, Marco Metra, Zubin J. Eapen, Piotr Ponikowski, Gerasimos Filippatos, James L. Januzzi, Rahul S. Loungani, Adriaan A. Voors, G. Michael Felker, John R. Teerlink, Peter S. Pang, Beth A. Davison, Barry H. Greenberg, Alan B. Miller, Claudio Gimpelewicz, Chien-Wei Chen, David E. Lanfear, Ileana L. Piña, Larry A. Allen, Gad Cotter
Publikováno v:
JACC: Heart Failure. 8:999-1008
Objectives This study sought to better understand the discrepant results of 2 trials of serelaxin on acute heart failure (AHF) and short-term mortality after AHF by analyzing causes of death of patients in the RELAX-AHF-2 (Efficacy, Safety and Tolera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4fafdf4eae7220c0e35623b1faf030
https://doi.org/10.1016/j.jchf.2020.09.010
https://doi.org/10.1016/j.jchf.2020.09.010
Autor:
Gad Cotter, Claudio Gimpelewicz, Peter S. Pang, Piotr Ponikowski, Iziah E Sama, Siting Feng, Gerasimos Filippatos, Thomas Holbro, John R. Teerlink, Adriaan A. Voors, G. Michael Felker, Barry H. Greenberg, Chien-Wei Chen, Thomas Severin, Satit Janwanishstaporn, Marco Metra, Beth A. Davison
Publikováno v:
European Journal of Heart Failure. 22:726-738
AIMS Although left ventricular ejection fraction (LVEF) is routinely used to categorize patients with heart failure (HF), whether it predicts outcomes after hospitalization for acute heart failure (AHF) is uncertain. Consequently, we assessed the rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fbaf5fda01435fb7fac4932c9bb855
https://doi.org/10.1002/ejhf.1772
https://doi.org/10.1002/ejhf.1772
Autor:
Thomas Holbro, Emma Ispasanie, Michael Kammüller, Gerd Pluschke, Christine Thorburn, Natasa Zamurovic, Anna Schubart, Lukas Muri
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
To assess the relative contribution of opsonisation by antibodies, classical and alternative complement pathways to pneumococcal phagocytosis, we analyzed killing of pneumococci by human blood leukocytes collected from vaccine-naïve and PCV13-vaccin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d0995fc39d201de2bbc63646960679
http://europepmc.org/articles/PMC8543009
http://europepmc.org/articles/PMC8543009
Autor:
Thomas Holbro, Christine Thorburn, Michael Kammüller, Gerd Pluschke, Natasa Zamurovic, Anna Schubart, Lukas Muri, Emma Ispasanie
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Dysregulation of complement activation causes a number of diseases, including paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. These conditions can be treated with monoclonal antibodies (mAbs) that bind to the complement co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a90d5fb3c3b968830cfff391cba3c7
Autor:
Thomas Holbro, Haraldsson Boerje, Nicholas Webb, Peter End, Anna Schubart, Guido Junge, Julie Milojevic
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims The alternative complement pathway (AP) provides the central amplification loop of complement activation and is critically involved in a number of diseases including C3 glomerulopathy (C3G), paroxysmal nocturnal haemoglobinuria (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2afc06dd4e4dbbf50261846faef568d
https://doi.org/10.1093/ndt/gfaa140.mo042
https://doi.org/10.1093/ndt/gfaa140.mo042