Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas Heidlauf"'
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 10, p e1005773 (2017)
Contractions on the descending limb of the total (active + passive) muscle force-length relationship (i. e. when muscle stiffness is negative) are expected to lead to vast half-sarcomere-length inhomogeneities. This is however not observed in experim
Externí odkaz:
https://doaj.org/article/729949a5e7c04846aa77a8dd8afda1d5
Publikováno v:
Journal of Computational Science. 19:86-96
This article presents an application of model order reduction techniques to a numerical model computing electromyographic (EMG) signals. The considered EMG model is a combination of the extracellular bidomain equation with a parameterized nonlinear m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f5579f8ea7db578c2d67e1173d8506
https://doi.org/10.1016/j.jocs.2017.01.009
https://doi.org/10.1016/j.jocs.2017.01.009
Publikováno v:
WIREs Systems Biology and Medicine. 11
Mathematical models and computer simulations have the great potential to substantially increase our understanding of the biophysical behavior of the neuromuscular system. This, however, requires detailed multiscale, and multiphysics models. Once vali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88504adc238f0e5a5ebc7d94cbbebf2d
https://doi.org/10.1002/wsbm.1457
https://doi.org/10.1002/wsbm.1457
Autor:
Roger Mundry, Heiko Stark, Oliver Röhrle, Fabian T. Neininger, Thomas Heidlauf, Kornelius Kupczik
Publikováno v:
Journal of Theoretical Biology. 382:34-43
Skeletal muscle models are used to investigate motion and force generation in both biological and bioengineering research. Yet, they often lack a realistic representation of the muscle's internal architecture which is primarily composed of muscle fib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83784c61c120b439b63d56e90fe77f23
https://doi.org/10.1016/j.jtbi.2015.06.034
https://doi.org/10.1016/j.jtbi.2015.06.034
Publikováno v:
Computational and Mathematical Methods in Medicine, Vol 2016 (2016)
Computational and Mathematical Methods in Medicine
Computational and Mathematical Methods in Medicine
A biophysical model of the excitation-contraction pathway, which has previously been validated for slow-twitch and fast-twitch skeletal muscles, is employed to investigate key biophysical processes leading to peripheral muscle fatigue. Special emphas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcf6f9aea97909f28d306ac75299cf9
https://doaj.org/article/7cb15eb19ca646029fab3bf1bd196138
https://doaj.org/article/7cb15eb19ca646029fab3bf1bd196138
Autor:
Thomas Heidlauf, Soroush Safaei, Chris P. Bradley, Poul M. F. Nielsen, Peter Hunter, David Ladd, Martyn P. Nash, Vijayaraghavan Rajagopal, Sebastian Krittian, Ting Yu, Tim Wu, David P. Nickerson, Thiranja P. Babarenda Gamage, Randall Britten, Caton Little, Andrew Cookson, Andy Bowery, David J. Paterson, Martin Steghöfer, Alejandro F. Frangi, Rafael Sebastian, Heye Zhang, Stig W. Omholt, Øyvind Nordbø, Kumar Mithraratne, Adam Reeve, Oliver Röhrle, Richard Christie, Vincent Budelmann, Oscar Camara, Ali Pashaei
Publikováno v:
Progress in Biophysics and Molecular Biology. 107:32-47
The VPH/Physiome Project is developing the model encoding standards CellML (cellml.org) and FieldML (fieldml.org) as well as web-accessible model repositories based on these standards (models.physiome.org). Freely available open source computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790ed3e711eeb8971af98d18bef33361
https://doi.org/10.1016/j.pbiomolbio.2011.06.015
https://doi.org/10.1016/j.pbiomolbio.2011.06.015
Autor:
Thomas Heidlauf, James R. Craig
Publikováno v:
Advances in Water Resources. 32:353-360
Existing analytical solutions to 2D and 3D contaminant transport problems are limited by the mathematically convenient assumption of uniform flow. An approximate method is developed herein for coordinate mapping of 2D (vertically-averaged) transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45547f1fba30bbaffaa0fd272e7c743c
https://doi.org/10.1016/j.advwatres.2008.11.013
https://doi.org/10.1016/j.advwatres.2008.11.013
Autor:
Thomas Heidlauf, Thomas Klotz, Christian Bleiler, Oliver Röhrle, Ekin Altan, Tobias Siebert, Christian Rode
Publikováno v:
Biomechanics and modeling in mechanobiology. 15(6)
Although recent research emphasises the possible role of titin in skeletal muscle force enhancement, this property is commonly ignored in current computational models. This work presents the first biophysically based continuum-mechanical model of ske
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd29ae9016252c823c21049b9e33927a
https://pubmed.ncbi.nlm.nih.gov/26935301
https://pubmed.ncbi.nlm.nih.gov/26935301
Publikováno v:
PAMM. 16:85-86
A continuum-mechanical finite element model of skeletal muscle contractions that includes force enhancement based on actin-titin interaction is presented. This model can simulate muscles with a descending limb in the total force-length relation, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bffe1786d228227125d3b02314ed642
https://doi.org/10.1002/pamm.201610031
https://doi.org/10.1002/pamm.201610031
Publikováno v:
An Integrated Model of the Neuromuscular System.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=erc_________::cce9eff76b218c022b92e803e81a1fe1