Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Thomas Harman"'
Autor:
Thomas Harman, Michael Udoh, Dan L. McElroy, Lyndsey L. Anderson, Richard C. Kevin, Samuel D. Banister, Adam Ametovski, Jack Markham, Chris Bladen, Peter T. Doohan, Quentin Greba, Robert B. Laprairie, Terrance P. Snutch, Iain S. McGregor, John G. Howland, Jonathon C. Arnold
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: T-type Ca2+ channels (Cav3) represent emerging therapeutic targets for a range of neurological disorders, including epilepsy and pain. To aid the development and optimisation of new therapeutics, there is a need to identify novel chemical
Externí odkaz:
https://doaj.org/article/8b1b021c9bdb4638b63894720a9176fe
Autor:
Thomas McInally, Darren S. Lee, Steve Brough, Zacharias Amara, Thomas Harman, Martyn Poliakoff, Barrie Rhodes, Gary Patrick Reid, Simon Woodward
Publikováno v:
Organic Process Research & Development. 19:831-840
Methods for the batch scale up of DABAL-Me3 promoted direct ester to amide synthesis have been demonstrated at 10–100 g scales using a tert-amide model compound. Procedures for 20 g scale couplings in standard laboratory glassware and up to 0.1 kg
Autor:
Arwen R. Pearson, Thomas Harman, Thomas Woodhall, Adam D. Daniels, Adam Nelson, Jennifer Stockwell, Alan Berry, Tomas Lebl, Claire L. Windle, Keith R. Mulholland, Chi H. Trinh
The catalysis of reactions involving fluoropyruvate as donor by N-acetyl neuraminic acid lyase (NAL) variants was investigated. Under kinetic control, the wild-type enzyme catalysed the reaction between fluoropyruvate and N-acetyl mannosamine to give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b4e7305d5331e56a3201123957266d
https://eprints.whiterose.ac.uk/91457/8/c5ob02037a.pdf
https://eprints.whiterose.ac.uk/91457/8/c5ob02037a.pdf
Publikováno v:
Tetrahedron. 68:7719-7722
A one-pot, three-component process is described which involves both organo- and enzyme-catalysed carbon–carbon bond-forming steps. In the first step, an organocatalyst catalyses the aldol reaction between acetaldehyde and a glyoxylamide. After dilu
Autor:
Martyn Poliakoff, Zacharias Amara, Thomas Harman, Simon Woodward, Barrie Rhodes, Steve Brough, Gary Patrick Reid, Thomas McInally, Darren S. Lee
Publikováno v:
ChemInform. 46
Methods for the batch scale up of DABAL-Me3 promoted direct ester to amide synthesis have been demonstrated at 10–100 g scales using a tert-amide model compound. Procedures for 20 g scale couplings in standard laboratory glassware and up to 0.1 kg
Autor:
Chi H. Trinh, Alan Berry, Arwen R. Pearson, Adam Nelson, Thomas Harman, Amanda H. Bolt, Ivan Campeotto, Simon E. V. Phillips, Caitriona Dennis
Publikováno v:
Journal of Molecular Biology
The substrate specificity of Escherichia coli N-acetylneuraminic acid lyase was previously switched from the natural condensation of pyruvate with N-acetylmannosamine, yielding N-acetylneuraminic acid, to the aldol condensation generating N-alkylcarb
Autor:
Pyeong Jun Yoo, Imad L. Al-Qadi, Katherine Petros, Nelson Gibson, Thomas Harman, John D'Angelo, Mostafa A. Elseifi, Samer Dessouky
Publikováno v:
Transportation Research Record: Journal of the Transportation Research Board. 2087:81-90
The Mechanistic-Empirical Pavement Design Guide (MEPDG) uses the complex modulus to simulate the time and temperature dependency of hot-mix asphalt (HMA). To account for the time dependency of HMA, MEPDG recommends calculation of the frequency of the
Publikováno v:
International Journal of Pavement Engineering. 8:29-43
Moisture damage in asphalt pavements is one of the primary distresses that is associated with the disintegration of the pavement surface, excessive cracking and permanent deformation. Moisture damage is a function of the chemical and physical propert
Publikováno v:
Transportation Research Record: Journal of the Transportation Research Board. 2005:95-103
Because of the stiffness differences between aggregates and mastics, permanent deformation of asphalt concrete is localized mainly in the soft mastics. Therefore, studies on the microresponse of the aggregates and mastics could provide a better under
Publikováno v:
International Journal of Pavement Engineering. 3:19-28
Air void distribution has considerable influence on the mechanical properties of asphalt mixtures. Several factors such as the compaction effort, method of compaction, aggregate gradation, and aggregate shape control the air void distribution. An X-r