Výsledky vyhledávání - "Thomas H. Porter"

New 2-methyl-6-alkylamino-5,8-quinolinequinones and 1,2,3,4-tetrahydro derivatives

Autor: Thomas H. Porter, Yieh-Ping Wan, Karl Folkers

Publikováno v: Journal of Heterocyclic Chemistry. 11:519-524

The syntheses of six new 2-methyl-6-alkylamino-5,8-quinolinequinones, three 1,2,3,4-tetrahydro-5,8-quinolinequinones, and 7-(2′,6′,10′-trimethylundecyl)-6-hydroxy-5,8-quinolinequinone are described as potential antimetabolites of coenzyme Q and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9747c0e3a4b4cb51ef0a5c16c0256f2c
https://doi.org/10.1002/jhet.5570110414

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The site of inhibition of mitochondrial electron transfer by coenzyme Q analogues

Autor: Henry R. Roberts, Sangkot Marzuki, Wan Mee Choo, Thomas H. Porter, Stuart C. Smith, Karl Folkers, Anthony W. Linnane

Publikováno v: Archives of Biochemistry and Biophysics. 191:306-315

The effects of 33 quinone derivatives on mitochondrial electron transfer in yeast were examined. Twenty-two of the compounds were also tested for their effects on the growth of yeast cells. Four strong inhibitors of electron transfer were identified:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b0fbcf8608864094c2e2b67e32e5fb
https://doi.org/10.1016/0003-9861(78)90093-0

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Antimetaboliten des Coenzyms Q. Möglichkeiten ihrer Anwendung als Antimalaria-Mittel

Autor: Karl Folkers, Thomas H. Porter

Publikováno v: Angewandte Chemie. 86:635-645

Die Malaria wird auf den Menschen durch den Stich der Anopheles-Mucke ubertragen; der Mensch fungiert als Zwischenwirt und die Mucke als Endwirt fur die Plasmodien. Gegen einige Chemotherapeutica sind die Plasmodien resistent geworden. Ein neues Konz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cffede82dbfeebe5dc19005ea29db0e
https://doi.org/10.1002/ange.19740861705

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Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase, by adriamycin and other quinones having antitumor activity

Autor: Thomas H. Porter, Inge L. Hansen, Karl Folkers, Yoshifumi Iwamoto

Publikováno v: Biochemical and Biophysical Research Communications. 58:633-638

Summary Adriamycin, carminomycin, and daunorubicin inhibit the coenzyme Q 10 -enzymes, succinoxidase and NADH-oxidase. Adriamycin 14-octanoate, which is more lipoidal than adriamycin, was the most effective inhibitor of the anthracyclines for both en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d9db4e7d4d1e6ba7c8939c0ef09e48
https://doi.org/10.1016/s0006-291x(74)80465-1

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Inhibition by adriamycin of the mitochondrial biosynthesis of coenzyme Q10 and implication for the cardiotoxicity of adriamycin in cancer patients

Autor: Thomas H. Porter, Tatsuo Watanabe, Karl Folkers, Margaret Liu

Publikováno v: Biochemical and Biophysical Research Communications. 77:1536-1542

Summary Steps were standardized as a control system for the mitochondrial biosynthesis of coenzyme Q 10 from radioactive p-hydroxybenzoic acid. In this system, adriamycin inhibited the biosynthesis. Adriamycin and the reference inhibitor of the funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aecdd531a526b04c9e7aab41244e7a2
https://doi.org/10.1016/s0006-291x(77)80152-6

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Antimalarial Quinones for Prophylaxis Based on a Rationale of Inhibition of Electron Transfer in Plasmodium

Autor: Thomas H. Porter, Karl Folkers, Yieh-Ping Wan

Publikováno v: Proceedings of the National Academy of Sciences. 71:952-956

Knowledge of the biochemistry of Plasmodium is emerging as a new field. Previous studies showed that the parasite apparently requires electron transfer for energy, and techniques to study such energy mechanisms are available. The discovery of the exi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e31afaed0f2ce4b519baea3c91dd7cb
https://doi.org/10.1073/pnas.71.3.952

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