Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Thomas H. Norwood"'
Autor:
Mary J. Emond, Maria del Carmen Cárdenas-Cortés, Julia M. Sidorova, Thomas H. Norwood, Lawrence A. Loeb, Ashwini S. Kamath-Loeb, Jeny Flores-Morales, Raymond J. Monnat, Gabriela Elisa Mercado-Celis, Alessandra Carnevale, Diego G. Zavala-van Rankin
Publikováno v:
Scientific Reports
Loss-of-function mutations in the WRN helicase gene cause Werner syndrome- a progeroid syndrome with an elevated risk of cancer and other age-associated diseases. Large numbers of single nucleotide polymorphisms have been identified in WRN. We report
Autor:
Thomas N. Wight, Sarah Hawley, Richard C. LeBaron, Kathleen R. Braun, Thomas H. Norwood, Stephen P. Evanko, Lawrence D. True, Christina K. Chan
Publikováno v:
The Prostate. 69:149-158
BACKGROUND Proteoglycans, a complex group of extracellular matrix (ECM) molecules, are elevated in benign prostatic hyperplasia (BPH). Versican is a stromal proteoglycan present in prostate tissue. Versican expression is elevated in tissues with incr
Publikováno v:
Clinical Genetics. 13:164-168
Trisomy for an F-like chromosome with banding characteristics of chromosome 20 was observed, respectively, in 25 and 8% of amniotic fluid cell clones in two cases of prenatal diagnosis for advanced maternal age. No such aneuploidy was found upon exam
Autor:
Lawrence A. Loeb, Piper M. Treuting, Ted Gooley, Bradley D. Preston, Ranga N. Venkatesan, Warren C. Ladiges, Evan D. Fuller, Thomas H. Norwood, Robert E. Goldsby
Publikováno v:
Molecular and Cellular Biology. 27:7669-7682
Eukaryotic DNA polymerase δ (Pol δ) is an essential, highly conserved enzyme that participates in DNA replication, DNA repair, and genetic recombination. Pol δ is believed to replicate a large portion of the genome, synthesizing most of the laggin
Autor:
Steven J. Kussick, Jonathan R. Fromm, Anthony Rossini, Ying Li, Anthony Chang, Thomas H. Norwood, Brent L. Wood
Publikováno v:
American Journal of Clinical Pathology. 124:170-181
Autor:
Thomas H. Norwood, Scott M. Schuetze, Ernest U. Conrad, Karen Swisshelm, Anthony Chang, Brian P. Rubin
Publikováno v:
International Journal of Surgical Pathology. 13:185-195
Inflammatory leiomyosarcoma, a rare entity first described in 1995, has been characterized by smooth muscle differentiation, a near-haploid karyotype, and a surprisingly good prognosis. The morphology is similar to that of conventional leiomyosarcoma
Autor:
Thomas H. Norwood, Era L. Pogosova-Agadjanyan, Derek L. Stirewalt, S Braswell, H S Yi, Steven J. Kussick, Jerry Radich, Brent L. Wood, K M Sheets
Publikováno v:
Leukemia. 18:1591-1598
In a 5-year survey of nonpromyelocytic/nonmonocytic acute myeloid leukemias (AMLs) diagnosed in the University of Washington Hematopathology Laboratory, we identified 19 cases containing distinctive, cup-like nuclear indentation in 10% or more of the
Autor:
Sohail K. Mirza, Janet F. Eary, James D. Bruckner, Ernest U. Conrad, Scott M. Schuetze, Thomas H. Norwood, Brian P. Rubin
Publikováno v:
Journal of Clinical Oncology. 20:3586-3591
PURPOSE: Dermatofibrosarcoma protuberans is caused by activation of the platelet-derived growth factor B (PDGFB) receptor, a transmembrane tyrosine kinase. We investigated the response of dermatofibrosarcoma protuberans to the tyrosine kinase inhibit
Autor:
Janna E. Quinn, Robert L. Vessella, Thomas H. Norwood, Kent R. Buhler, Nigel Clegg, William J. Ellis, Lawrence D. True, Peter S. Nelson, Jill A. Macoska, Alvin Y. Liu, Paul H. Lange, Emily C. Williams
Publikováno v:
The American Journal of Pathology. 161:705-715
The late stages of progression of prostate carcinoma are typically characterized by an androgen-insensitive, rapidly proliferative state. Some late-stage tumors are composed predominantly of neuroendocrine cells. Virtually no animal models of a neuro
Autor:
R. Scott Hansen, Stanley M. Gartler, Giorgio Gimelli, Thomas H. Norwood, K. M. Anwarul Hassan
Publikováno v:
Human Genetics. 109:452-462
Mutation in the DNMT3B DNA methyltransferase gene is a common cause of ICF (immunodeficiency, centromeric heterochromatin, facial anomalies) immunodeficiency syndrome and leads to hypomethylation of satellites 2 and 3 in pericentric heterochromatin.