Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Thomas H. Leung"'
Autor:
Jianhe Huang, Satish Sati, Christina Murphy, Casey A. Spencer, Emmanuel Rapp, Stephen M. Prouty, Scott Korte, Olivia Ahart, Emily Sheng, Parker Jones, Anna E. Kersh, Denis Leung, Thomas H. Leung
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114742- (2024)
Summary: Mammals typically heal with fibrotic scars, and treatments to regenerate human skin and hair without a scar remain elusive. We discovered that mice lacking C-X-C motif chemokine receptor 2 (CXCR2 knockout [KO]) displayed robust and complete
Externí odkaz:
https://doaj.org/article/842d739eea944b0ea61fb1e5adb5059f
Autor:
Shreya Bhattacharya, Sayon Basu, Emily Sheng, Christina Murphy, Jenny Wei, Anna E. Kersh, Caroline A. Nelson, Joshua S. Bryer, Hovik A. Ashchyan, Katherine Steele, Amy Forrestel, John T. Seykora, Robert G. Micheletti, William D. James, Misha Rosenbach, Thomas H. Leung
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 1 (2023)
Background Acute febrile neutrophilic dermatosis (Sweet syndrome) is a potentially fatal multiorgan inflammatory disease characterized by fever, leukocytosis, and a rash with a neutrophilic infiltrate. The disease pathophysiology remains elusive, and
Externí odkaz:
https://doaj.org/article/a0c5dcf981104343b387ffb3f44bf29b
Autor:
Jing-Jing Wang, Michelle K. Siu, Yu-Xin Jiang, Thomas H. Leung, David W. Chan, Ran-Ran Cheng, Annie N. Cheung, Hextan Y. Ngan, Karen K. Chan
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Blockade of the programmed cell death 1(PD-1)/PD-1 ligand-1(PD-L1) pathway has been exploited therapeutically in many cancer types. Upregulation of PD-L1 in tumor cells contributes to malignancy through suppression of the T cell-mediated antitumor re
Externí odkaz:
https://doaj.org/article/7236f54c6ddd45d694f4b18d0374486d
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3383-3392.e5 (2018)
Summary: Physicians have observed that surgical wounds in the elderly heal with thinner scars than wounds in young patients. Understanding this phenomenon may reveal strategies for promoting scarless wound repair. We show that full-thickness skin wou
Externí odkaz:
https://doaj.org/article/be7a10c5991348eca3b296c0bb1a89ef
Publikováno v:
PLoS Genetics, Vol 18, Iss 3, p e1010121 (2022)
3D genome organization regulates gene expression, and disruption of these long-range (>20kB) DNA-protein interactions results in pathogenic phenotypes. Chromosome conformation methods in conjunction with chromatin immunoprecipitation were used to dec
Externí odkaz:
https://doaj.org/article/735d3153a5414037910746bcb9da1cad
Autor:
Surya A. Veerabagu, Rebecca Trinklein, Jeremy R. Etzkorn, Thomas H. Leung, Christopher J. Miller, Ilana S. Rosman, Adam J. Friedman
Publikováno v:
Journal of the American Academy of Dermatology. 88:922-924
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a34a517404fe1ad8a6a15e08020de06
https://doi.org/10.1016/j.jaad.2022.10.054
https://doi.org/10.1016/j.jaad.2022.10.054
Autor:
Shreya Bhattacharya, Sayon Basu, Emily Sheng, Christina Murphy, Jenny Wei, Anna E. Kersh, Caroline A. Nelson, Joshua S. Bryer, Hovik A. Ashchyan, Katherine Steele, Amy Forrestel, John T. Seykora, Robert G. Micheletti, William D. James, Misha Rosenbach, Thomas H. Leung
Publikováno v:
The Journal of clinical investigation.
Acute febrile neutrophilic dermatosis (Sweet syndrome) is a potentially fatal multiorgan inflammatory disease characterized by fever, leukocytosis, and a rash with a neutrophilic infiltrate. Disease pathophysiology remains elusive, and current dogma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248eb14f0ab8abcc776c6d406425f860
https://pubmed.ncbi.nlm.nih.gov/36355435
https://pubmed.ncbi.nlm.nih.gov/36355435
Autor:
Thomas H. Leung, George Cotsarelis
Publikováno v:
The New England journal of medicine. 386(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f1c21dff8a08a10629ed5aaec4337c
https://pubmed.ncbi.nlm.nih.gov/35196433
https://pubmed.ncbi.nlm.nih.gov/35196433
Autor:
Emma H. Weiss, Christine J. Ko, Thomas H. Leung, Robert G. Micheletti, Arash Mostaghimi, Sarika M. Ramachandran, Misha Rosenbach, Caroline A. Nelson
Publikováno v:
Current dermatology reports. 11(2)
Neutrophilic dermatoses are defined by the presence of a sterile neutrophilic infiltrate on histopathology. This review focuses on the pathogenesis, epidemiology, clinicopathological features, diagnosis, and management of four disorders: Sweet syndro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb4fbcb7968ecdc3319ccf48a5c4d36
https://pubmed.ncbi.nlm.nih.gov/35310367
https://pubmed.ncbi.nlm.nih.gov/35310367
Autor:
Sameera Peraramelli, Qi Zhou, Qin Zhou, Bettina Wanko, Lei Zhao, Toshihiko Nishimura, Thomas H. Leung, Seiya Mizuno, Mamoru Ito, Timothy Myles, Thomas M. Stulnig, John Morser, Lawrence L.K. Leung
Publikováno v:
J Thromb Haemost
BACKGROUND: Osteopontin (OPN) is a multifunctional proinflammatory matricellular protein overexpressed in multiple human cancers and associated with tumor progression and metastases. Thrombin cleavage of OPN reveals a cryptic binding site for α(4)β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a42cba05d55c5e1170a617db3b9660
https://pubmed.ncbi.nlm.nih.gov/35108449
https://pubmed.ncbi.nlm.nih.gov/35108449