Výsledky vyhledávání - "Thomas H. Large"

SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action

Autor: Una Campbell, Kerry L. Spear, Taleen Hanania, Seth C. Hopkins, Liming Shao, John Emmerson Campbell, Emer Leahy, Philip Jones, Nina Dedic, Kenneth S. Koblan, Thomas H. Large, Robert Lew

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 371:1-14

For the past 50 years, the clinical efficacy of antipsychotic medications has relied on blockade of dopamine D2 receptors. Drug development of non-D2 compounds, seeking to avoid the limiting side effects of dopamine receptor blockade, has failed to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2808a2c8f936f84a6ad2fd06dc5207ea
https://doi.org/10.1124/jpet.119.260281

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SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D

Autor: Nina, Dedic, Philip G, Jones, Seth C, Hopkins, Robert, Lew, Liming, Shao, John E, Campbell, Kerry L, Spear, Thomas H, Large, Una C, Campbell, Taleen, Hanania, Emer, Leahy, Kenneth S, Koblan

Publikováno v: The Journal of pharmacology and experimental therapeutics. 371(1)

For the past 50 years, the clinical efficacy of antipsychotic medications has relied on blockade of dopamine D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6abe30bb2f6c41edcc044f11b3be6420
https://pubmed.ncbi.nlm.nih.gov/31371483

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In vivo phenotypic drug discovery: applying a behavioral assay to the discovery and optimization of novel antipsychotic agents

Autor: Q. Kevin Fang, John Emmerson Campbell, Una Campbell, Philip Jones, Noel Aaron Powell, Vadim Alexandrov, Emily Sabath, Liming Shao, Kerry L. Spear, Irene Morganstern, Thomas H. Large, Taleen Hanania, Hua M. Zhong

Publikováno v: MedChemComm. 7:1093-1101

Phenotypic drug discovery (PDD) is increasingly being recognized as a viable compliment to target-based drug discovery (TDD). By measuring functional changes, typically at a systems level, PDD can facilitate the identification of compounds having a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe09535f97f43c9fa55f35e30eca47e3
https://doi.org/10.1039/c6md00128a

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Tangicraft

Autor: Lydia Davison, David Bar-El, Marcelo Worsley, Thomas H. Large

Publikováno v: ASSETS

With millions of players worldwide, Minecraft has become a rich context for playing, socializing and learning for children. However, as is the case with many video games, players must rely heavily on vision to navigate and participate in the game. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43a7956f4e2015bc409981abfdbef028
https://doi.org/10.1145/3234695.3241031

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Multimodal Interfaces for Inclusive Learning

Autor: Timothy Mwiti, Lydia Davison, David Bar-El, Thomas H. Large, Marcelo Worsley

Publikováno v: Lecture Notes in Computer Science ISBN: 9783319938455
AIED (2)

In this paper, we propose that the artificial intelligence in education (AIED) community lead the charge in leveraging multimodal interfaces, in conjunction with artificial intelligence, to advance learning interfaces and experiences that are more in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::effc6ebc5281e51ff2f6278db17b1b9b
https://doi.org/10.1007/978-3-319-93846-2_73

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Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain

Autor: Michael Klimas, David Borsook, Alexandre Coimbra, David Bleakman, Richard Hargreaves, Lino Becerra, Jaymin Upadhyay, Jeffrey L. Evelhoch, William Z. Potter, Richard Baumgartner, Smriti Iyengar, Thomas H. Large, Adam J. Schwarz, Edward George

Publikováno v: Drug Discovery Today. 17:964-973

Substance P (SP) and neurokinin-1 receptors (NK-1R) are localized within central and peripheral sensory pain pathways. The roles of SP and NK-1R in pain processing, the anatomical distribution of NK-1R and efficacy observed in preclinical pain studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fe704608e3d073ba78d4fd52b4dd2e
https://doi.org/10.1016/j.drudis.2012.05.004

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Test-retest reliability of evoked heat stimulation BOLD fMRI

Autor: Julie Anderson, Richard Hargreaves, David Borsook, Jordan Lemme, David Bleakman, Jaymin Upadhyay, Lino Becerra, Jeffrey L. Evelhoch, Thomas H. Large

Publikováno v: Journal of neuroscience methods. 253

To date, the blood oxygenated-level dependent (BOLD) functional magnetic resonance imaging (fMRI) technique has enabled an objective and deeper understanding of pain processing mechanisms embedded within the human central nervous system (CNS). In ord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c07f6e368d55af0fee233b11bab28a
https://pubmed.ncbi.nlm.nih.gov/26072245

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Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor: Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine

Autor: G. Erik Jagdmann, Joseph P. Tizzano, David O. Callagaro, Darryle D. Schoepp, Michael P. Johnson, Thomas H. Large, James A. Monn, Thomas C. Britton, Melvyn Baez

Publikováno v: Journal of Medicinal Chemistry. 46:3189-3192

This report describes recently discovered novel allosteric modulators of metabotropic glutamate2 (mGlu2) receptors. These pyridylmethylsulfonamides (e.g., 3) potentiate glutamate, shifting agonist potency by 2-fold. This effect was specific for mGlu2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81cfce582d17cc9ab1d5c4038c66071f
https://doi.org/10.1021/jm034015u

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Novel human D-amino acid oxidase inhibitors stabilize an active-site lid-open conformation

Autor: Q. K. Fang, Lawrence Chun, Thomas H. Large, Loredano Pollegioni, Michelle L. R. Heffernan, Larry W. Hardy, Ryan T. Terry-Lorenzo, Scott P. Brown, M. A. Orsini, Kerry L. Spear

Publikováno v: Bioscience Reports, Vol 34, Iss 4, p e00133 (2014)
Bioscience Reports

The NMDAR (N-methyl-D-aspartate receptor) is a central regulator of synaptic plasticity and learning and memory. hDAAO (human D-amino acid oxidase) indirectly reduces NMDAR activity by degrading the NMDAR co-agonist D-serine. Since NMDAR hypofunction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a72d62a14af870d505a4b022831487
http://www.bioscirep.org/bsr/034/e133/bsr034e133.htm

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Expression of Full-Length trkB Receptors by Reactive Astrocytes after Chronic CNS Injury

Autor: Robert J. McKeon, Jerry Silver, Thomas H. Large

Publikováno v: Experimental Neurology. 148:558-567

Growth factors, including members of the neurotrophin family, are expressed by neuronal and glial elements following injury to the CNS. In order to assess the capacity for glial cells to respond to neurotrophins at sites of chronic injury, full-lengt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0852ea5c65d1e8caef5f162888493564
https://doi.org/10.1006/exnr.1997.6698

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