Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Thomas H. Ermak"'
Autor:
Scott Kitchener, Jean Lang, Xiaochu Duan, Marie-Jose Quentin-Millet, Philip Bedford, Richard A. Nichols, Thomas H. Ermak, Remi Forrat, Farshad Guirakhoo, Karen McCarthy, Dennis Morrison, Thomas P. Monath, Niranjan Kanesa-thasan, Sutee Yoksan
Publikováno v:
Human Vaccines. 2:60-67
A randomized double-blind Phase I Trial was conducted to evaluate safety, tolerability, and immunogenicity of a yellow fever (YF)-dengue 2 (DEN2) chimera (ChimeriVax-DEN2) in comparison to that of YF vaccine (YF-VAX). Forty-two healthy YF naive adult
Autor:
Nathan Brown, Fred Mitchell, Megan Parsons, Thomas H. Ermak, Jean Lang, Thomas P. Monath, Zhenxi Zhang, Farshad Guirakhoo, Samantha Brandler
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 72:74-81
ChimeriVax-dengue (DEN) viruses are live attenuated vaccine candidates. They are constructed by replacing the premembrane (prM) and envelope (E) genes of the yellow fever (YF) 17D virus vaccine with the corresponding genes from wild-type DEN viruses
Autor:
Joseph E. Hill, James A. Boden, Jennifer Ingrassia, Kenneth F. Soike, Heather L. Gray, Weltzin Richard A, Cynthia K. Lee, Paul J. Giannasca, Thomas P. Monath, Thomas H. Ermak, Kathleen Georgakopoulos, Harold Kleanthous, James Blanchard, Timothy Tibbitts
Publikováno v:
Vaccine. 17:1493-1505
Rhesus monkeys, naturally colonized with H. pylori as indicated by culture and histology were immunized with either 40 mg recombinant H. pylori urease administered orally together with 25 microg Escherichia coli heat-labile enterotoxin (LT) or immuni
Autor:
Thomas P. Monath, Cynthia K. Lee, Harold Kleanthous, John Nedrud, Richard A. Nichols, Gwendolyn A. Myers, Weltzin Richard A, Paul J. Giannasca, Thomas H. Ermak
Publikováno v:
The Journal of Experimental Medicine
We examined the roles of cell- and antibody-mediated immunity in urease vaccine–induced protection against Helicobacter pylori infection. Normal and knockout mice deficient in major histocompatibility complex (MHC) class I, MHC class II, or B cell
Autor:
Thomas H Ermak, Paul J Giannasca
Publikováno v:
Advanced Drug Delivery Reviews. 34:261-283
M cells are epithelial cells specialized for sampling viruses and bacteria and perform a critical role in immune surveillance in mucosal tissues. The M cell apical surface is modified with less frequent microvilli and a thinner glycocalyx, and the ba
Autor:
Heather L. Gray, Wende Lei, Thomas P. Monath, Gwendolyn A. Myers, Thomas H. Ermak, Richard Nichols, Harry Kleanthous, Jennifer Ingrassia, Kathleen Georgakopoulos, Cynthia K. Lee, Ru Ding, Zhen-Zi Zhang, Timothy Tibbitts
Publikováno v:
Infection and Immunity. 66:2879-2886
To determine the optimal inductive sites for immunization against Helicobacter pylori infection, the protective efficacy of recombinant urease (rUre) was assessed for mice given the vaccine by either the oral (p.o.), intranasal (i.n.), or rectal rout
Publikováno v:
Cell & Tissue Research. 279:433-436
In this study, we demonstrate the role of M cells in uptake of poly(D-L-lactic-co-glycolic acid) (PLGA) microspheres and transport into rabbit Peyer's patches. Microspheres 1 to 10 microns in diameter composed of 50:50 lactic acid:glycolic acid were
Publikováno v:
Cell & Tissue Research. 269:403-410
The distribution patterns of extracellular matrix elements were determined to ascertain whether they play a role in the localization of lymphocytes in discrete T-cell, B-cell and dome antigen-processing domains within Peyer's patches. Antibodies agai
Publikováno v:
American Journal of Anatomy. 190:10-18
The structure and function of colonic mucosal lymphoid organs remain largely unexplored, especially in the rectum hidden within the pelvic vault. Two-month-old female BALB/c mice were anesthetized, and the entire colon was removed from cecum to anus.
Publikováno v:
Clinical Immunology and Immunopathology. 56:373-383
Murine lupus in NZB/NZW ( B W ) mice is characterized by immune-complex glomerulonephritis and lymphocytic infiltration of several organs, including the kidney. We recently showed that treatment of B W mice with F(ab′)2 anti-CD4 monoclonal antibody