Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Thomas H. Charpentier"'
Autor:
Jeffrey L. Benovic, Julio Aguirre-Ghiso, Andrew E. Aplin, Philip B. Wedegaertner, Naiming Zhou, Gregory G. Tall, Takami Sato, Mizue Terai, Shihua Wu, Lihong Zhang, Thomas H. Charpentier, Dougan McGrath, Timothy J. Purwin, Clinita E. Randolph, Eduardo Farias, Dominic Lapadula
GNAQ and GNA11 sequence analysis of UM002B cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc86c2aecfa02c9d2318332d673c3913
https://doi.org/10.1158/1541-7786.22513482.v1
https://doi.org/10.1158/1541-7786.22513482.v1
Autor:
Lihong Zhang, Mizue Terai, Eduardo F. Farias, Julio A. Aguirre-Ghiso, Clinita E. Randolph, Naiming Zhou, Takami Sato, Timothy J. Purwin, Philip B. Wedegaertner, Andrew E. Aplin, Gregory G. Tall, Shihua Wu, Dougan McGrath, Thomas H. Charpentier, Dominic Lapadula, Jeffrey L. Benovic
Publikováno v:
Molecular Cancer Research. 17:963-973
Uveal melanoma is the most common intraocular tumor in adults and often metastasizes to the liver, leaving patients with few options. Recurrent activating mutations in the G proteins, Gαq and Gα11, are observed in approximately 93% of all uveal mel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ec0ef9d739207f58e518f436be3b7e
https://doi.org/10.1158/1541-7786.mcr-18-0574
https://doi.org/10.1158/1541-7786.mcr-18-0574
Autor:
Philip B. Wedegaertner, Mizue Terai, Naiming Zhou, Gregory G. Tall, Clinita E. Randolph, Julio A. Aguirre-Ghiso, Takami Sato, Jeffrey L. Benovic, Timothy J. Purwin, Lihong Zhang, Dougan McGrath, Thomas H. Charpentier, Eduardo F. Farias, Andrew E. Aplin, Dominic Lapadula, Shihua Wu
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0b9e86e85f1d1f3ae534cad2bf75566
https://doi.org/10.1096/fasebj.2019.33.1_supplement.815.9
https://doi.org/10.1096/fasebj.2019.33.1_supplement.815.9
Autor:
Adam D. Pierce, Padmavani Bezawada, David B. Neau, E. Prabhu Raman, David J. Weber, Paul T. Wilder, Kristen M. Varney, Eric A. Toth, Andrew Coop, Laura E. McKnight, Michael C. Cavalier, Alexander D. MacKerell, Milad J. Alasady, Mohd. Imran Ansari, Thomas H. Charpentier
Publikováno v:
Journal of Medicinal Chemistry. 59:592-608
The drug pentamidine inhibits calcium-dependent complex formation with p53 ((Ca)S100B·p53) in malignant melanoma (MM) and restores p53 tumor suppressor activity in vivo. However, off-target effects associated with this drug were problematic in MM pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7129e63cfd8b8b77844ef5975d78bf5a
https://doi.org/10.1021/acs.jmedchem.5b01369
https://doi.org/10.1021/acs.jmedchem.5b01369
Publikováno v:
Biochemistry. 52:4810-4819
Multiple extracellular stimuli, such as growth factors and antigens, initiate signaling cascades through tyrosine phosphorylation and activation of phospholipase C-γ (PLC-γ) isozymes. Like most other PLCs, PLC-γ1 is basally autoinhibited by its X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ba0874db2dbe1c246250b11ae8c7713
https://doi.org/10.1021/bi400433b
https://doi.org/10.1021/bi400433b
Autor:
Emily G. Lowery-Gionta, Thomas H. Charpentier, G L Waldo, John Sondek, T. Kendall Harden, Krzysztof Krajewski, Brian D. Strahl, Thomas L. Kash
In contrast to G protein-coupled receptors, for which chemical and peptidic inhibitors have been extensively explored, few compounds are available that directly modulate heterotrimeric G proteins. Active Gα q binds its two major classes of effectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a6a02245bfbd84cdc8d44c09f20a90
Autor:
Klaus Mohr, Michael Hölzel, John Sondek, Evelyn Gaffal, Thomas H. Charpentier, Graeme Milligan, Céline Galés, Tanja Slodczyk, Harald Dargatz, Tobias Bald, Junken Aoki, Yuji Shinjo, Daniel Tietze, Maike Effern, Anna Lena Schmitz, Asuka Inoue, Sylvain Armando, Henrik G. Dohlman, Anne Stößel, Ramona Schrage, Ségolène Galandrin, Gabriele M. König, Michael Hesse, Katrin M. Büllesbach, Christa E. Müller, Manuel Grundmann, Christel Drewke, Stefan Kehraus, Andrew B. Tobin, Diana Imhof, T. Kendall Harden, Suvi Annala, Stéphane A. Laporte, Jesus Gomeza, Thomas Tüting, Velten Horn, Naveen Shridhar, Nicole Merten, Yoon Namkung, Adrian J. Butcher, Daniela Wenzel, Laura Jenkins, Evi Kostenis, Michel Bouvier, Bernd K. Fleischmann, Matthew K. Martz
Publikováno v:
Nature Communications
Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b26f05dca16b186dc13b71425c09af5
https://eprints.gla.ac.uk/115886/1/115886.pdf
https://eprints.gla.ac.uk/115886/1/115886.pdf
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df597fcebb517c17deb203f601e809d5
https://doi.org/10.1096/fasebj.29.1_supplement.897.12
https://doi.org/10.1096/fasebj.29.1_supplement.897.12
Autor:
Paul T. Wilder, Jing Lin, Catherine L. Bair, Thomas H. Charpentier, Dong Yang, Melissa Liriano, Kristen M. Varney, Andrew Lee, Amos B. Oppenheim, Sankar Adhya, France Carrier, David J. Weber
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1763:1284-1297
S100B is an EF-hand containing calcium-binding protein of the S100 protein family that exerts its biological effect by binding and affecting various target proteins. A consensus sequence for S100B target proteins was published as (K/R)(L/I)xWxxIL and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9a5525f9aa519c0c95f59cc07358c0
https://doi.org/10.1016/j.bbamcr.2006.08.024
https://doi.org/10.1016/j.bbamcr.2006.08.024
Autor:
Weigang Huang, Thomas H. Charpentier, Qisheng Zhang, G L Waldo, John Sondek, T. Kendall Harden, Matthew O. Barrett
Publikováno v:
The Journal of biological chemistry. 289(43)
All peripheral membrane proteins must negotiate unique constraints intrinsic to the biological interface of lipid bilayers and the cytosol. Phospholipase C-β (PLC-β) isozymes hydrolyze the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e011f9a4ff4b697056e12fdbb2faa787
https://pubmed.ncbi.nlm.nih.gov/25193662
https://pubmed.ncbi.nlm.nih.gov/25193662