Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas H. Burkey"'
Publikováno v:
Pain. 113:113-122
Tumor necrosis factor alpha (TNFalpha) and interleukin 1beta (IL-1beta) are pro-inflammatory cytokines capable of altering the sensitivity of sensory neurons. Because sensitization elicited by IL-1beta and TNFalpha is blocked by inhibition of the ind
Autor:
Yoshiaki Hosohata, Frank Porreca, Henry I. Yamamura, Carl J. Kovelowski, George R. Uhl, Michael H. Ossipov, Josephine Lai, Todd W. Vanderah, Thomas H Burkey, Kenner C. Rice, Victor J. Hruby, William R. Roeske, Ichiro Sora, Xiaoyan Zhang
Publikováno v:
European Journal of Pharmacology. 388:241-248
We examined the effects of [ d -Pen 2 , d -Pen 5 ]enkephalin (DPDPE), [ d -Ala 2 ,Glu 4 ]deltorphin (DELT), and (+)-4-[(α R )-α((2 S ,5 R )-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N , N -diethylbenzamide (SNC80) on [ 35 S]GTPγS bindi
Autor:
Eva V. Varga, Henry I. Yamamura, Thomas H Burkey, Victor J. Hruby, Keiko Hosohata, Josue Alfaro-Lopez, William R. Roeske
Publikováno v:
European Journal of Pharmacology. 346:111-114
Recently two tetrapeptide ligands that bind preferentially to the μ-opioid receptor were identified and named endomorphin-1 and endomorphin-2. We examined the ability of these peptides to stimulate G protein activation in human μ-opioid receptor tr
Autor:
F Porreca, Thomas H Burkey, Eva V. Varga, Frederick J. Ehlert, Keiko Hosohata, Scott Cowell, Henry I. Yamamura, Xiaoping Li, Hiroshi Nagase, William R. Roeske, Dagmar Stropova, Victor J. Hruby, Yoshiaki Hosohata, Cheryl A. Slate, Raymond M. Quock
Publikováno v:
Life Sciences. 62:1531-1536
Delta-opioid receptor-selective drugs may provide an alternative to mu-opioid-selective drugs currently used for the relief of pain. To develop improved delta-opioid receptor-selective drugs, better measures of drug activity are necessary. In this re
Autor:
John W. Regan, Thomas H Burkey
Publikováno v:
Biochemical and Biophysical Research Communications. 211:152-158
Mitogen-activated protein (MAP) kinases are involved with cellular proliferation, and while the traditional activators of these kinases have been the growth factor receptors, recent data indicate that G-protein coupled receptors which inhibit adenyly
Autor:
Robert O. Webster, Thomas H. Burkey
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1175:312-318
The ability of physiological concentrations of adenosine to inhibit formylmethionylleucylphenylalanine (fMLP)-stimulated superoxide anion (O2-) generation, adherence and degranulation is well established in human neutrophils. However, the mechanism o
Publikováno v:
Methods in molecular medicine. 99
There is increasing use of isolated sensory neuronal preparations to examine the cellular mechanisms involved in pain signaling. Indeed, these in viro preparations have several advantages that make them beneficial for examining physiological and/or p
Publikováno v:
Pain Research ISBN: 9781588291035
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78405561641a274c28bcad4dfc9a86ac
https://doi.org/10.1385/1-59259-770-x:055
https://doi.org/10.1385/1-59259-770-x:055
Publikováno v:
Pain Research ISBN: 9781588291035
There is increasing use of isolated sensory neuronal preparations to examine the cellular mechanisms involved in pain signaling. Indeed, these in viro preparations have several advantages that make them beneficial for examining physiological and/or p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38a1252b58780745c13f6e0c38666915
https://doi.org/10.1385/1-59259-770-x:189
https://doi.org/10.1385/1-59259-770-x:189
Autor:
Victor J. Hruby, Henry I. Yamamura, Thomas H Burkey, Frank Porreca, Todd W. Vanderah, Eva V. Varga, William R. Roeske, Keiko Hosohata, Jennifer K Logan
Publikováno v:
European journal of pharmacology. 392(3)
We examined the role of the gamma(2) subunit of G proteins (Ggamma(2)) in the antinociception produced by c[D-Pen(2), D-Pen(5)]enkephalin (DPDPE) in mice. DPDPE produced 84.0+/-9.0% antinociception in vehicle-treated mice. After intracerebroventricul