In chemico, in vitro and in vivo comparison of the skin sensitizing potential of eight unsaturated and one saturated lipid compounds

Autor: David Hart, Ursula G. Sauer, Reinhard Kreiling, Dorothea Eigler, Peter Ungeheuer, Thomas H. Broschard, Joanna Kupny, Qiang Li, Marcus Kleber, Birte Dreeßen, Veronika Höpflinger, Helge Gehrke

Publikováno v: Regulatory toxicology and pharmacology : RTP. 90

The applicability of the Direct Peptide Reactivity Assay (DPRA), the KeratinoSens™ assay and the human cell line activation test (OECD Test Guidelines 442C, 442D, 442E) in predicting the skin sensitising potential of nine lipid (bio)chemicals was i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a191126a2f839e03bd054a66f07b259
https://pubmed.ncbi.nlm.nih.gov/28958912

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010

Autor: Anna Bal-Price, J.G.M. Bessems, Hannu Komulainen, Susan P. Felter, Klaus Ejner Andersen, Emanuela Testai, Greet Schoeters, Aldert H. Piersma, George P. Daston, Valérie Zuang, Vera Rogiers, Gavin Maxwell, Ursula Gundert-Remy, David A. Basketter, Ulrike Bernauer, Mathieu Vinken, Ian Kimber, Aynur O. Aptula, Mark T. D. Cronin, Emilio Benfenati, Stuart Creton, George Loizou, Elise Grignard, Esther Brandon, Alexandre Angers-Loustau, Albrecht Poth, Joost H.M. van Delft, Michael Schwarz, Sofia B. Leite, Sarah Adler, Jan van Benthem, Pascal Phrakonkham, Jos C. S. Kleinjans, Sandra Coecke, Sharon Munn, Joachim Kreysa, Wolfgang Dekant, Silvia Casati, Guillermo Repetto, Henk Van Loveren, Reinhard Kreiling, Thomas H. Broschard, Susanne Bremer, Olavi Pelkonen, Stefan Pfuhler, Alan R. Boobis, Paolo Mazzatorta, Pilar Prieto, Andrew Worth, Jose-Manuel Zaldivar, Hanna Tähti, Raffaella Corvi, Tuula Heinonen, Frédéric Y. Bois, Rositsa Serafimova

Publikováno v: Vrije Universiteit Brussel
Archives of Toxicology, 85(5), 367-485. Springer
Archives of toxicology
Adler, S, Basketter, D, Creton, S, Pelkonen, O, van Benthem, J, Zuang, V, Andersen, K E, Angers-Loustau, A, Aptula, A, Bal-Price, A, Benfenati, E, Bernauer, U, Bessems, J, Bois, F Y, Boobis, A, Brandon, E, Bremer, S, Broschard, T, Casati, S, Coecke, S, Corvi, R, Cronin, M, Daston, G, Dekant, W, Felter, S, Grignard, E, Gundert-Remy, U, Heinonen, T, Kimber, I, Kleinjans, J, Komulainen, H, Kreiling, R, Kreysa, J, Leite, S B, Loizou, G, Maxwell, G, Mazzatorta, P, Munn, S, Pfuhler, S, Phrakonkham, P, Piersma, A, Poth, A, Prieto, P, Repetto, G, Rogiers, V, Schoeters, G, Schwarz, M, Serafimova, R, Tähti, H, Testai, E, van Delft, J, van Loveren, H, Vinken, M, Worth, A & Zaldivar, J-M 2011, ' Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010 ', Archives of Toxicology, vol. 85, no. 5, pp. 367-485 . https://doi.org/10.1007/s00204-011-0693-2

The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics on the market in Europe after 2013. In that context, the European Commission invited stakeholder bodies (industry, non-governmental organisations, EU Member Stat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e974111045922b66d7c9117f0f0d7f
https://doi.org/10.1007/s00204-011-0693-2

Toxicokinetics and biotransformation of 3-(4-methylbenzylidene)camphor in rats after oral administration

Autor: Thomas H. Broschard, Wolfgang Dekant, Ute M.D. Schauer, Wolfgang Völkel, Thomas Colnot

Publikováno v: Toxicology and Applied Pharmacology. 216:331-338

3-(4-Methylbenzylidene)camphor (4-MBC) is an UV-filter frequently used in sunscreens and cosmetics. Equivocal findings in some screening tests for hormonal activity initiated a discussion on a possible weak estrogenicity of 4-MBC. In this study, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6152ac72bec69379a0338e157f4cb48b
https://doi.org/10.1016/j.taap.2006.05.012

Activation of estrogen receptor α and ERβ by 4-methylbenzylidene-camphor in human and rat cells: comparison with phyto- and xenoestrogens

Autor: Jacqueline Shields-Botella, Remi Delansorne, Poppy Arifin Firzani, Stefan O. Mueller, Margret Kling, Astrid Mecky, Thomas H. Broschard, Eric Duranti, P.-J. Kramer

Publikováno v: Toxicology Letters. 142:89-101

4-Methylbenzylidene-camphor (4-MBC) is an organic sunscreen that protects against UV radiation and may therefore help in the prevention of skin cancer. Recent results on the estrogenicity of 4-MBC have raised concerns about a potential of 4-MBC to ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7803c6464b3b8cf0a65319a08db9b1
https://doi.org/10.1016/s0378-4274(03)00016-x

Translesional synthesis on DNA templates containing site-specifically placed deoxyadenosine and deoxyguanosine adducts formed by the plant carcinogen aristolochic acid

Autor: Heinz H. Schmeiser, Claus-Wilhelm von der Lieth, Manfred Wiessler, Thomas H. Broschard

Publikováno v: Carcinogenesis. 15:2331-2340

Synthetic oligonucleotides (18-mers) containing either a single deoxyadenosine residue or a single deoxyguanosine residue were treated with aristolochic acid I (AAI) or aristolochic acid II (AAII), the main components of the plant carcinogen aristolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a528448b6697760c3dbf3aa6d888d01f
https://doi.org/10.1093/carcin/15.10.2331