Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Thomas H Segall‐Shapiro"'
Autor:
Thomas H Segall‐Shapiro, Adam J Meyer, Andrew D Ellington, Eduardo D Sontag, Christopher A Voigt
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 7, Pp 1-15 (2014)
Abstract Synthetic genetic systems share resources with the host, including machinery for transcription and translation. Phage RNA polymerases (RNAPs) decouple transcription from the host and generate high expression. However, they can exhibit toxici
Externí odkaz:
https://doaj.org/article/0405cffdbbbd46c2b8b385d1c51d34fe
Autor:
Virgil A Rhodius, Thomas H Segall‐Shapiro, Brian D Sharon, Amar Ghodasara, Ekaterina Orlova, Hannah Tabakh, David H Burkhardt, Kevin Clancy, Todd C Peterson, Carol A Gross, Christopher A Voigt
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-13 (2013)
Abstract Cells react to their environment through gene regulatory networks. Network integrity requires minimization of undesired crosstalk between their biomolecules. Similar constraints also limit the use of regulators when building synthetic circui
Externí odkaz:
https://doaj.org/article/008a5930ca7040cdb7fd5b0a748f5ffe
Autor:
Andrew M. King, Daniel A. Anderson, Emerson Glassey, Thomas H. Segall-Shapiro, Zhengan Zhang, David L. Niquille, Amanda C. Embree, Katelin Pratt, Thomas L. Williams, D. Benjamin Gordon, Christopher A. Voigt
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Peptide secondary metabolites have a diverse range of functions. Here the authors present a method to design and screen a large library of modified peptides in E. coli against a target of interest.
Externí odkaz:
https://doaj.org/article/a0b742cce7f140439048d5716ca317c3
Autor:
Kamyab Javanmardi, Thomas H. Segall-Shapiro, Chia-Wei Chou, Daniel R. Boutz, Randall J. Olsen, Xuping Xie, Hongjie Xia, Pei-Yong Shi, Charlie D. Johnson, Ankur Annapareddy, Scott Weaver, James M. Musser, Andrew D. Ellington, Ilya J. Finkelstein, Jimmy D. Gollihar
SummaryThe worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the repeated emergence of variants of concern. The Omicron variant has two dominant sub-lineages, BA.1 and BA.2, each with unprecedented numbers of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd6c5d8d1cd37f2e3ea5434dd57c680
https://doi.org/10.1101/2022.04.18.488614
https://doi.org/10.1101/2022.04.18.488614
Autor:
Daniel A. Anderson, Amanda C. Embree, Thomas Williams, Andrew M. King, David L. Niquille, Christopher A. Voigt, Thomas H. Segall-Shapiro, Zhengan Zhang, Katelin Pratt, Emerson Glassey, D. Benjamin Gordon
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Peptide secondary metabolites are common in nature and have diverse pharmacologically-relevant functions, from antibiotics to cross-kingdom signaling. Here, we present a method to design large libraries of modified peptides in Escherichia coli and sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5af1bb33f5e0c1fc38e67c2cb5664b8
http://europepmc.org/articles/PMC8566587
http://europepmc.org/articles/PMC8566587
Autor:
Zivko L. Nikolov, Jimmy Gollihar, Ching-Lin Hsieh, Ilya J. Finkelstein, Elizabeth C Gardner, Andrew P. Horton, Thomas H. Segall-Shapiro, Laura Soto-Sierra, Andre C. Maranhao, Kamyab Javanmardi, Gejji, William N. Voss, Abhinay Gontu, Ruth H. Nissly, Ankur Annapareddy, Michelle Byrom, John M. Dye, Andrew S. Herbert, Foteini Bartzoka, Andrew D. Ellington, Daniel R. Boutz, Anna Battenhouse, Nianshuang Wang, Cardona Ja, Kapur, Jule Goike, Gregory C. Ippolito, Johanson Mj, Susan L. Woodard, Jason J. Lavinder, Abbassi S, Foster Er, James M. Musser, Jason S. McLellan, George Georgiou, Edward M. Marcotte, Zhou L, Suresh V. Kuchipudi, Rebecca L. Renberg, R. A. Hughes
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 2
article-version (status) pre
article-version (number) 2
The ongoing evolution of SARS-CoV-2 into more easily transmissible and infectious variants has sparked concern over the continued effectiveness of existing therapeutic antibodies and vaccines. Hence, together with increased genomic surveillance, meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345d56439a31016a754b4a05c08edae5
https://doi.org/10.1101/2021.04.07.438849
https://doi.org/10.1101/2021.04.07.438849
Publikováno v:
Nature Biotechnology. 40:799-799
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ee4b988c330a4b53d2cbc0c5c5024cf
https://doi.org/10.1038/s41587-022-01300-7
https://doi.org/10.1038/s41587-022-01300-7
Publikováno v:
Nature Biotechnology. 36:352-358
The internal environment of growing cells is variable and dynamic, making it difficult to introduce reliable parts, such as promoters, for genetic engineering. Here, we applied control-theoretic ideas to design promoters that maintained constant leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70aac3394557b03008459bea05c84ad5
https://doi.org/10.1038/nbt.4111
https://doi.org/10.1038/nbt.4111
Publikováno v:
Nature chemical biology. 15(2)
Cellular processes are carried out by many genes, and their study and optimization requires multiple levers by which they can be independently controlled. The most common method is via a genetically encoded sensor that responds to a small molecule. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9988016685d16687d89946da1e585faa
https://pubmed.ncbi.nlm.nih.gov/30478458
https://pubmed.ncbi.nlm.nih.gov/30478458
Cellular processes are carried out by many interacting genes and their study and optimization requires multiple levers by which they can be independently controlled. The most common method is via a genetically-encoded sensor that responds to a small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd1b81816beea6454a593ece103dc78