Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Thomas H McConville"'
Autor:
Monica Mehta, Lawrence J Purpura, Thomas H McConville, Matthew J Neidell, Michaela R Anderson, Elana J Bernstein, Donald E Dietz, Justin Laracy, Shauna H Gunaratne, Emily Happy Miller, Jennifer Cheng, Jason Zucker, Shivang S Shah, Shaoli Chaudhuri, Christian A Gordillo, Shreena R Patel, Tai Wei Guo, Lara E Karaaslan, Ran Reshef, Benjamin A Miko, Joan M Bathon, Marcus R Pereira, Anne-Catrin Uhlemann, Michael T Yin, Magdalena E Sobieszczyk
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249349 (2021)
BackgroundTocilizumab, an interleukin-6 receptor blocker, has been used in the inflammatory phase of COVID-19, but its impact independent of corticosteroids remains unclear in patients with severe disease.MethodsIn this retrospective analysis of pati
Externí odkaz:
https://doaj.org/article/5075db336f054b76ac431f1a9fc9e285
Autor:
Wenjing Geng, Yujie Qi, Wenting Li, Thomas H McConville, Alexandra Hill-Ricciuti, Emily C Grohs, Lisa Saiman, Anne-Catrin Uhlemann
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0211845 (2020)
PurposeLittle is known about the molecular epidemiology of Staphylococcus aureus in Chinese neonatal intensive care units (NICUs). We describe the molecular epidemiology of S. aureus isolated from neonates on admission to Beijing Children's Hospital.
Externí odkaz:
https://doaj.org/article/cfbcddca0a524268be49a2bff98455eb
Autor:
Khuram U. Ashraf, Rie Nygaard, Owen N. Vickery, Satchal K. Erramilli, Carmen M. Herrera, Thomas H. McConville, Vasileios I. Petrou, Sabrina I. Giacometti, Meagan Belcher Dufrisne, Kamil Nosol, Allen P. Zinkle, Chris L. B. Graham, Michael Loukeris, Brian Kloss, Karolina Skorupinska-Tudek, Ewa Swiezewska, David I. Roper, Oliver B. Clarke, Anne-Catrin Uhlemann, Anthony A. Kossiakoff, M. Stephen Trent, Phillip J. Stansfeld, Filippo Mancia
Publikováno v:
Nature
The outer membrane of Gram-negative bacteria has an external leaflet that is largely composed of lipopolysaccharide, which provides a selective permeation barrier, particularly against antimicrobials1. The final and crucial step in the biosynthesis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423ffae297550f841ce5cdb98dd07627
http://wrap.warwick.ac.uk/163073/1/WRAP-Structural-Lipopolysaccharide-maturation-O-antigen-ligase-2022.pdf
http://wrap.warwick.ac.uk/163073/1/WRAP-Structural-Lipopolysaccharide-maturation-O-antigen-ligase-2022.pdf
Autor:
Qiuhu Shi, Anne-Catrin Uhlemann, Thomas H. McConville, Eloise D. Austin, Wenjing Geng, Divya Balasubramanian, Victor J. Torres, Christine J. Kubin
Publikováno v:
Antimicrob Agents Chemother
Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections are associated with significant morbidity and mortality. MRSA secretes a number of virulence factors and pore-forming toxins that enable tissue invasion. Prior studies have fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58dc6e9bf0148757352f51dc23b8af05
https://europepmc.org/articles/PMC8765464/
https://europepmc.org/articles/PMC8765464/
Autor:
Jason Zucker, Logan Bartram, Thomas H. McConville, Brian Nelson, Anne-Catrin Uhlemann, Michael May, Jennifer L. Small-Saunders, Magdalena E. Sobieszczyk, Donald Dietz, Elizabeth Istorico, Angela Gomez-Simmonds, Christine J. Kubin
Publikováno v:
Open Forum Infectious Diseases
Background Patients hospitalized with coronavirus disease 2019 (COVID-19) are at increased risk of health care–associated infections (HAIs), especially with prolonged hospital stays. We sought to identify incidence, antimicrobial susceptibilities,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a2117114449e61157ed10b15e5e951
https://doi.org/10.1093/ofid/ofab201
https://doi.org/10.1093/ofid/ofab201
Publikováno v:
STAR Protocols
Summary Multi-drug resistant (MDR) Klebsiella pneumoniae remains an urgent public health threat. While whole-genome sequencing has helped identify genetic changes underlying resistance, functional validation remains difficult due to a lack of genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f4570ff0bd01a928f80c6960abf8bd5
https://pubmed.ncbi.nlm.nih.gov/33733242
https://pubmed.ncbi.nlm.nih.gov/33733242
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100373-(2021)
Summary Multi-drug resistant (MDR) Klebsiella pneumoniae remains an urgent public health threat. While whole-genome sequencing has helped identify genetic changes underlying resistance, functional validation remains difficult due to a lack of genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7b1768fbee89d6a666612ae462ce5a
http://www.sciencedirect.com/science/article/pii/S2666166721000800
http://www.sciencedirect.com/science/article/pii/S2666166721000800
Autor:
Tania Wong Fok Lung, Daniel Charytonowicz, Kristin G. Beaumont, Shivang S. Shah, Shwetha H. Sridhar, Claire L. Gorrie, Andre Mu, Casey E. Hofstaedter, David Varisco, Thomas H. McConville, Marija Drikic, Brandon Fowler, Andreacarola Urso, Wei Shi, Dario Fucich, Medini K. Annavajhala, Ibrahim N. Khan, Irina Oussenko, Nancy Francoeur, Melissa L. Smith, Brent R. Stockwell, Ian A. Lewis, Abderrahman Hachani, Swikrity Upadhyay Baskota, Anne-Catrin Uhlemann, Danielle Ahn, Robert K. Ernst, Benjamin P. Howden, Robert Sebra, Alice Prince
Publikováno v:
Cell Metab
K. pneumoniae sequence type 258 (Kp ST258) is a major cause of healthcare-associated pneumonia. However, it remains unclear how it causes protracted courses of infection in spite of its expression of immunostimulatory lipopolysaccharide, which should
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9b2e03bf8cf94c08f2fce57f1f6375
https://doi.org/10.1016/j.cmet.2022.03.009
https://doi.org/10.1016/j.cmet.2022.03.009
Autor:
Thomas H. McConville, Shivang S. Shah, Tania Wong Fok Lung, Alice Prince, Robert K. Ernst, Anne-Catrin Uhlemann, Alexander M. Chong, Danielle Ahn, Medini K. Annavajhala, Victor G. Castano, Gitanjali Bhushan, Casey E. Hofstaedter, Rajesh Kumar Soni
Publikováno v:
Cell reports
SUMMARY Klebsiella pneumoniae ST258 is a human pathogen associated with poor outcomes worldwide. We identify a member of the acyltransferase superfamily 3 (atf3), enriched within the ST258 clade, that provides a major competitive advantage for the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddf7c9a3010f15d8e6119ff6482a2ef
https://pubmed.ncbi.nlm.nih.gov/34077733
https://pubmed.ncbi.nlm.nih.gov/34077733
Autor:
Carmen M. Herrera, Gitanjali Bhushan, Filippo Mancia, Medini K. Annavajhala, Marla J. Giddins, Thomas H. McConville, Danielle Ahn, Michael Stephen Trent, Nenad Macesic, Anne-Catrin Uhlemann, Felix D Rozenberg
Publikováno v:
SSRN Electronic Journal.
Polymyxin resistance (PR) threatens the treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. PR frequently arises through the chemical modification of the lipid-A portion of lipopolysaccharide. Various mutations have been implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc5ec34f1935e52d26279e5ecd7309b4
https://doi.org/10.2139/ssrn.3634809
https://doi.org/10.2139/ssrn.3634809