Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Thomas H Lanthorn"'
Autor:
David R Powell, Jason P Gay, Nathaniel eWilganowski, Deon eDoree, Katerina V Savelieva, Thomas H Lanthorn, Robert eRead, Peter eVogel, Gwenn M Hansen, Robert eBrommage, Zhi-Ming eDing, Urvi eDesai, Brian eZambrowicz
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2015)
After creating >4650 knockouts (KOs) of independent mouse genes, we screened them by high-throughput phenotyping and found that cannabinoid receptor 1 (Cnr1) KO mice had the same lean phenotype published by others. We asked if our KOs of DAG lipase a
Externí odkaz:
https://doaj.org/article/2cd8cddb02a7428f8fc63bddb47507e2
Autor:
Wandong Zhang, Katerina V Savelieva, David T Tran, Vladimir M Pogorelov, Emily B Cullinan, Kevin B Baker, Kenneth A Platt, Sean Hu, Indrani Rajan, Nianhua Xu, Thomas H Lanthorn
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45500 (2012)
Receptor tyrosine phosphatase gamma (PTPRG, or RPTPγ) is a mammalian receptor-like tyrosine phosphatase which is highly expressed in the nervous system as well as other tissues. Its function and biochemical characteristics remain largely unknown. We
Externí odkaz:
https://doaj.org/article/49ec46596bfb4c59a97152346a0796f2
Autor:
Wandong Zhang, Katerina V Savelieva, Adisak Suwanichkul, Daniel L Small, Laura L Kirkpatrick, Nianhua Xu, Thomas H Lanthorn, Gui-Lan Ye
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11261 (2010)
Tmub1 (C7orf21/HOPS) encodes a protein containing a ubiquitin-like domain. Tmub1 is highly expressed in the nervous system. To study its physiological function, we generated mice with Tmub1 deleted by homologous recombination. The knockout mice were
Externí odkaz:
https://doaj.org/article/631edbbabd5b4fbaa44f05a83b203bd5
Autor:
Indrani Rajan, Katerina V Savelieva, Gui-Lan Ye, Ching-Yun Wang, Murtaza M Malbari, Carl Friddle, Thomas H Lanthorn, Wandong Zhang
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6612 (2009)
Histone deacetylase 4 (HDAC4) has been associated with muscle & bone development [1]-[6]. N-terminal MEF2 and RUNX2 binding domains of HDAC4 have been shown to mediate these effects in vitro. A complete gene knockout has been reported to result in pr
Externí odkaz:
https://doaj.org/article/c224c4ce01274467af46d908f44c626f
Autor:
Katerina V Savelieva, Shulei Zhao, Vladimir M Pogorelov, Indrani Rajan, Qi Yang, Emily Cullinan, Thomas H Lanthorn
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3301 (2008)
The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting enzymes, tryptophan hydroxylase-1 and -2 (TPH1 and TPH2). We used a gene
Externí odkaz:
https://doaj.org/article/4deb02d88eea46999606e491fb39465f
Autor:
James E. Grace, Brian Zambrowicz, Pradeep Vattikundala, Kenneth G. Carson, Jonathan Lippy, Clotilde Bourin, Alan Main, Alan Wilson, Sreenivasulu Naidu, Sandhya Mandlekar, Carolyn Diane Dzierba, Saravanan Elavazhagan, Walter Kostich, Gauri Shankar, Jeffrey M. Brown, Charles M. Conway, Charles F. Albright, Justin Vijay Louis, Yu-Wen Li, Vivek Sharma, Yanling Huang, Laszlo Kiss, Amr Nouraldeen, Susheel J. Nara, Martin A. Lewis, Ryan Westphal, Vinay K. Holenarsipur, Anand Balakrishnan, Amy Easton, Robert Zaczek, Jonathan C. Swaffield, Ted Molski, Rick L. Pieschl, Kevin Baker, Katerina Savelieva, Yingzhi Bi, Kenneth S. Santone, Linda J. Bristow, John E. Macor, Jianlin Feng, Guilan Ye, Joanne J. Bronson, Manish Lal Das, Reeba K. Vikramadithyan, Kevin O’Malley, Jason W. Allen, Brian D. Hamman, Michael Gulianello, Yifeng Lu, Thomas H. Lanthorn, Kimberley A. Lentz, Anoop Kumar, Manoj Dokania, Kumaran Dandapani, Rex Denton
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b1480bd30607a9fe64d0e01fbd6b27
http://europepmc.org/articles/PMC4998676
http://europepmc.org/articles/PMC4998676
Autor:
Indrani Rajan, Peter Vogel, Thomas H. Lanthorn, Sara S. Mason, Gui-Lan Ye, Kevin B. Baker, Katerina V. Savelieva
Publikováno v:
Behavioural Brain Research. 276:99-110
Spinal nerve L5/L6 ligation (SNL) in rats has become the standard for mechanistic studies of peripheral neuropathy and screening for novel analgesics. Conventional SNL in our hybrid mice resulted in a wide range of allodynia. Anatomical evaluation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39765388abf1d2d7a3bd38e7a6d0764
https://doi.org/10.1016/j.bbr.2014.04.039
https://doi.org/10.1016/j.bbr.2014.04.039
Autor:
Cynthia Anne Fink, Michael Alan Green, Thomas H. Lanthorn, Alan Wilson, G. Greg Zipp, Xuan-Chuan Yu, Katerina V. Savelieva, Amr Nouraldeen, Joseph Barbosa, Kristen M. Terranova, S. David Kimball
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3886-3890
The incidence of cognitive disorders such as Alzheimer's disease continues to increase unabated. While cures for such diseases have eluded investigators, progress is being made on alleviating certain symptoms of these diseases. Mouse knockouts of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18625e3d395454e52f08b02e678bf7b
https://doi.org/10.1016/j.bmcl.2014.06.049
https://doi.org/10.1016/j.bmcl.2014.06.049
Autor:
Eric Buxton, Arian Oldham, Nguyen Nghi, Thomas H. Lanthorn, Zhi-Cai Shi, Catherine Bomont, David T. Tran, Qingyun Liu, Shiv Patel, Xuan Chuan Yu, Wandong Zhang
Publikováno v:
Neuroscience Letters. 451:212-216
The mammalian proline transporter (PROT) is a high affinity Na(+)/Cl(-)-dependent transporter expressed in specific regions of the brain. It is homologous to other neurotransmitter transporters such as glycine, norepinephrine, serotonin, and dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96788bee6beace51d61e1753ac63bc12
https://doi.org/10.1016/j.neulet.2009.01.018
https://doi.org/10.1016/j.neulet.2009.01.018
Autor:
Thomas H. Lanthorn, Kevin B. Baker, Indrani Rajan, Peter Vogel, Katerina V. Savelieva, Wendy Jarman, Margaret L. Allen
Publikováno v:
Neuroscience Letters. 438:205-209
Genetic inhibition of the ephrin receptor (EphA6) in mice produced behavioral deficits specifically in tests of learning and memory. Using a fear conditioning training paradigm, mice deficient in EphA6 did not acquire the task as strongly as did wild
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f1ac9848fd4039e40607f568daa686
https://doi.org/10.1016/j.neulet.2008.04.013
https://doi.org/10.1016/j.neulet.2008.04.013