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pro vyhledávání: '"Thomas H Hraha"'
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 9, p e1005116 (2016)
Diabetes is caused by dysfunction to β-cells in the islets of Langerhans, disrupting insulin secretion and glucose homeostasis. Gap junction-mediated electrical coupling between β-cells in the islet plays a major role in coordinating a pulsatile se
Externí odkaz:
https://doaj.org/article/21ac402290314d54a37781d86d24567a
Autor:
Thomas H Hraha, Matthew J Westacott, Marina Pozzoli, Aleena M Notary, P Mason McClatchey, Richard K P Benninger
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 9, p e1003819 (2014)
The pancreatic islets of Langerhans are multicellular micro-organs integral to maintaining glucose homeostasis through secretion of the hormone insulin. β-cells within the islet exist as a highly coupled electrical network which coordinates electric
Externí odkaz:
https://doaj.org/article/c42a36ab7bf2460ba0fa3915c9458e0d
Publikováno v:
Biophysical Journal. 104:491a-492a
The pancreatic islet is a multicellular organ which provides the sole source of insulin for regulating blood glucose levels. Thus, a functional understanding of the islet is of critical importance to effectively treat diabetes. Beta cells within nati