Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice

Autor: Susanne Syberg, Solveig Petersen, Jens-Erik Beck Jensen, Alison Gartland, Jenni Teilmann, Iain Chessell, Thomas H. Steinberg, Peter Schwarz, Niklas Rye Jørgensen

Publikováno v: Journal of Osteoporosis, Vol 2012 (2012)

The purinergic P2X7 receptor is expressed by bone cells and has been shown to be important in both bone formation and bone resorption. In this study we investigated the importance of the genetic background of the mouse strains on which the P2X7 knock

Externí odkaz: https://doaj.org/article/8ff3cad7aa064479925ea51e018b83f2

P2X7Rs are involved in cell death, growth and cellular signaling in primary human osteoblasts

Autor: N. Nissen, Susanne Syberg, Niklas Rye Jørgensen, Derya Aslan, Tommy Korsgaard Larsen, Ankita Agrawal, Thomas H. Steinberg, Peter Schwarz, Solveig Petersen, Marie Solgaard, Zanne Henriksen

Publikováno v: Agrawal, A, Henriksen, Z, Syberg, S, Petersen, S, Aslan, D, Solgaard, M, Nissen, N, Larsen, T K, Schwarz, P, Steinberg, T H & Rye Jørgensen, N 2017, ' P2X7Rs are involved in cell death, growth and cellular signaling in primary human osteoblasts ', Bone, vol. 95, pp. 91-101 . https://doi.org/10.1016/j.bone.2016.11.011

The ionotropic ATP-gated P2X7 receptor (P2X7R) is involved in the regulation of many physiological functions including bone metabolism. Several studies on osteoblasts from rodents and human osteoblast-like cell lines have addressed the expression and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8e915811a9f6cba48d18fd0a8ee7f6
https://pubmed.ncbi.nlm.nih.gov/27856358

Use of the oral platelet inhibitors dipyridamole and acetylsalicylic acid is associated with increased risk of fracture

Autor: Niklas Rye Jørgensen, Thomas H. Steinberg, Peter Schwarz, Peter Vestergaard

Publikováno v: International Journal of Cardiology; Vol 160
Vestergaard, P, Steinberg, T H, Schwarz, P & Jørgensen, N R 2012, ' Use of the oral platelet inhibitors dipyridamole and acetylsalicylic acid is associated with increased risk of fracture ', International Journal of Cardiology . https://doi.org/10.1016/j.ijcard.2011.03.026

Background Platelet inhibitors are widely used in the treatment and prevention of coronary artery disease. In addition to acetylsalicylic acid, two major groups of platelet inhibitors are used; phosphodiesterase inhibitors including dipyridamole, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5601b6cf6bb2dacd58515a8736e677
https://doi.org/10.1016/j.ijcard.2011.03.026

An unusual cause of membranous glomerulonephritis in a patient with HIV

Autor: Thomas H. Steinberg, Luis Marcos, Helen Liapis, Ying Maggie Chen, Aubrey R. Morrison

Publikováno v: International Urology and Nephrology. 44:983-986

A 68-year old Caucasian male with a past medical history of human immunodeficiency virus (HIV) infection presented with acute oliguric renal failure and maculopapular rash. Renal biopsy demonstrated extensive foot process effacement as well as conflu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c45ee3399c07f28e283da9dd146c18d
https://doi.org/10.1007/s11255-011-9945-6

Regulation of RGS2 and Second Messenger Signaling in Vascular Smooth Muscle Cells by cGMP-dependent Protein Kinase

Autor: Thomas H. Steinberg, Patrick Osei-Owusu, Kendall J. Blumer, Ryan M. Drenan, Xiaoguang Sun

Publikováno v: Journal of Biological Chemistry. 282:31656-31665

RGS2, a GTPase-activating protein (GAP) for G(q)alpha, regulates vascular relaxation and blood pressure. RGS2 can be phosphorylated by type Ialpha cGMP-dependent protein kinase (cGKIalpha), increasing its GAP activity. To understand how RGS2 and cGKI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208b580587354482872453518d1f69d9
https://doi.org/10.1074/jbc.m706360200