Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thomas H, Snider"'
Autor:
Christina M. Wilhelm, Michael C. Babin, Gennady E. Platoff, Thomas H. Snider, David A. Jett, David T. Yeung
Organophosphorus (OP) compounds, including pesticides and chemical warfare nerve agents (CWNA), are threats to the general population as possible weapons of terrorism or by accidental exposure whether through inadvertent release from manufacturing fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33797c6913fb6a227f0fde736cb90a60
https://europepmc.org/articles/PMC6153028/
https://europepmc.org/articles/PMC6153028/
Autor:
Jeffery M. Gearhart, Mitchell L Meade, Thomas H. Snider, John J. Schlager, Andrea Hoffmann, Meghan K Makley
Publikováno v:
Brain Research. 1611:101-113
The brainstem represents a major tissue area affected by sarin organophosphate poisoning due to its function in respiratory and cardiovascular control. While the acute toxic effects of sarin on brainstem-related responses are relatively unknown, othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29944e9642d5d1bb0e322417bff6fe6c
Autor:
David A. Jett, Michael C. Babin, Kevin G. McGarry, Thomas H. Snider, Gennady E. Platoff, David T. Yeung
Publikováno v:
Fundamental toxicological sciences. 3(5)
The oral toxicity of phorate oxon (PHO), with emphasis on gender- and age-related effects, was characterized in the Sprague-Dawley rat. The oral LD50 (95% fiducial limits) for PHO in corn oil was 0.88 (0.79, 1.04) mg/kg in males and 0.55 (0.46, 0.63)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3f48e66c750bbce932cd83d19192a5
https://pubmed.ncbi.nlm.nih.gov/28856079
https://pubmed.ncbi.nlm.nih.gov/28856079
Autor:
Michael C. Babin, David T. Yeung, Thomas H. Snider, Gennady E. Platoff, David A. Jett, Christina M. Wilhelm
Publikováno v:
Toxicology and Applied Pharmacology. 281(3):254-265
The currently fielded pre-hospital therapeutic regimen for the treatment of organophosphorus (OP) poisoning in the United States (U.S.) is the administration of atropine in combination with an oxime antidote (2-PAM Cl) to reactivate inhibited acetylc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a43a9d01277d010f2047b740605c81c
Autor:
Jennifer L. Plahovinsak, John S. Graham, Mark R. Perry, Frances M. Reid, James V. Rogers, William R. Richter, Thomas H. Snider
Publikováno v:
Cutaneous and Ocular Toxicology. 33:161-167
Assessing the hazards of accidental exposure to toxic industrial chemical (TIC) vapors and evaluating therapeutic compounds or treatment regimens require the development of appropriate animal models.The objective of this project was to develop an exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0d71b859f37275961717830c13fa9c
https://doi.org/10.3109/15569527.2013.806524
https://doi.org/10.3109/15569527.2013.806524
Autor:
Thomas H. Snider, Ryan A. Bartlett, Kevin G. McGarry, Robert A. Moyer, Matthew K. Brittain, Nicholas J. Machesky, David T. Yeung
Publikováno v:
Advances in Bioscience and Biotechnology. :1020-1023
Acetylcholine is an essential neurotransmitter found throughout the nervous system. Its action on postsynaptic receptors is regulated through hydrolysis by various carboxylesterases, especially cholinesterases (ChEs). The acute toxicity of organophos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33c46bc08b4060ea4e1a4467da1bbf83
https://doi.org/10.4236/abb.2013.412136
https://doi.org/10.4236/abb.2013.412136
Publikováno v:
The Journal of toxicological sciences. 41(4)
Anticholinesterases, such as organophosphorus pesticides and warfare nerve agents, present a significant health threat. Onset of symptoms after exposure can be rapid, requiring quick-acting, efficacious therapy to mitigate the effects. The goal of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2aeea674e206f96cb3ee05524af42c5
https://pubmed.ncbi.nlm.nih.gov/27432237
https://pubmed.ncbi.nlm.nih.gov/27432237
Publikováno v:
The Journal of toxicological sciences. 40(6)
Given the rapid onset of symptoms from intoxication by organophosphate (OP) compounds, a quick-acting, efficacious therapeutic regimen is needed. A primary component of anti-OP therapy is an oxime reactivator to rescue OP-inhibited acetylcholinestera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f8310464c9d14551e202b7796607d4
https://pubmed.ncbi.nlm.nih.gov/26558457
https://pubmed.ncbi.nlm.nih.gov/26558457
Autor:
Kevin G, McGarry, Ryan A, Bartlett, Nicholas J, Machesky, Thomas H, Snider, Robert A, Moyer, David T, Yeung, Matthew K, Brittain
Publikováno v:
Advances in bioscience and biotechnology
Acetylcholine is an essential neurotransmitter found throughout the nervous system. Its action on postsynaptic receptors is regulated through hydrolysis by various carboxylesterases, especially cholinesterases (ChEs). The acute toxicity of organophos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53defb062613f8b34d75521d33124b00
https://pubmed.ncbi.nlm.nih.gov/24749000
https://pubmed.ncbi.nlm.nih.gov/24749000
Publikováno v:
Journal of Applied Toxicology. 19:S40-S45
A topical skin protectant (TSP) (ICD 2289) is being developed to protect service members from exposure to chemical warfare agents (CWA). The TSP is designed for use on the skin at the overgarment closures and other vulnerable areas to enhance protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c845ac01fc10c996d7de2b9cf176871
https://doi.org/10.1002/(sici)1099-1263(199912)19:1+3.0.co
https://doi.org/10.1002/(sici)1099-1263(199912)19:1+