Synthetic lethality between ATR and POLA1 reveals a potential new target for individualized cancer therapy

Autor: Hanna Elisabeth Schneider, Lisa-Maria Schmitt, Albert Job, Brigitte Lankat-Buttgereit, Thomas Gress, Malte Buchholz, Eike Gallmeier

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101038- (2024)

The ATR-CHK1 pathway plays a fundamental role in the DNA damage response and is therefore an attractive target in cancer therapy. The antitumorous effect of ATR inhibitors is at least partly caused by synthetic lethality between ATR and various DNA r

Externí odkaz: https://doaj.org/article/d9d2994e1d8b40feb85caf545e7e1dad

Fast reactive interdiffusion between solid brass and liquid aluminium

Autor: Vanessa Glück Nardi, Thomas Greß, Babette Tonn, Harald Schmidt, Wolfram Volk

Publikováno v: Results in Materials, Vol 20, Iss , Pp 100471- (2023)

The formation mechanisms of intermetallic layers and the development of the interface between solid brass and molten Al alloy were experimentally investigated using semi-infinite solid-liquid diffusion couples. Isothermal annealing of commercial CuZn

Externí odkaz: https://doaj.org/article/eaf177ce49174ea6bd24f16d5f79f984

A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer

Autor: Evangelina López de Maturana, Juan Antonio Rodríguez, Lola Alonso, Oscar Lao, Esther Molina-Montes, Isabel Adoración Martín-Antoniano, Paulina Gómez-Rubio, Rita Lawlor, Alfredo Carrato, Manuel Hidalgo, Mar Iglesias, Xavier Molero, Matthias Löhr, Christopher Michalski, José Perea, Michael O’Rorke, Victor Manuel Barberà, Adonina Tardón, Antoni Farré, Luís Muñoz-Bellvís, Tanja Crnogorac-Jurcevic, Enrique Domínguez-Muñoz, Thomas Gress, William Greenhalf, Linda Sharp, Luís Arnes, Lluís Cecchini, Joaquim Balsells, Eithne Costello, Lucas Ilzarbe, Jörg Kleeff, Bo Kong, Mirari Márquez, Josefina Mora, Damian O’Driscoll, Aldo Scarpa, Weimin Ye, Jingru Yu, PanGenEU Investigators, Montserrat García-Closas, Manolis Kogevinas, Nathaniel Rothman, Debra T Silverman, SBC/EPICURO Investigators, Demetrius Albanes, Alan A Arslan, Laura Beane-Freeman, Paige M Bracci, Paul Brennan, Bas Bueno-de-Mesquita, Julie Buring, Federico Canzian, Margaret Du, Steve Gallinger, J Michael Gaziano, Phyllis J Goodman, Marc Gunter, Loic LeMarchand, Donghui Li, Rachael E Neale, Ulrika Peters, Gloria M Petersen, Harvey A Risch, Maria José Sánchez, Xiao-Ou Shu, Mark D Thornquist, Kala Visvanathan, Wei Zheng, Stephen J Chanock, Douglas Easton, Brian M Wolpin, Rachael Z Stolzenberg-Solomon, Alison P Klein, Laufey T Amundadottir, Marc A Marti-Renom, Francisco X Real, Núria Malats

Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-18 (2021)

Abstract Background Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic var

Externí odkaz: https://doaj.org/article/fd82873a71df49c79bdc3dadb14c043b

873 Pharmacologic macrophage depletion affects metastasis formation by modulating systemic immune responses in a genetic pancreatic cancer model

Autor: Patrick Michl, Bence Sipos, Heidi Griesmann, Christof Drexel, Nada Milosevic, Thomas Gress

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Externí odkaz: https://doaj.org/article/6c74972ac6a04e26bc4722df4611531a

Hemorrhagic Diathesis in Borrelia recurrentis Infection Imported to Germany

Autor: Christian Keller, Malte Zumblick, Katrin Streubel, Markus Eickmann, Daniela Müller, Martina Kerwat, Stephan Becker, Thomas Gress

Publikováno v: Emerging Infectious Diseases, Vol 22, Iss 5, Pp 917-919 (2016)

Externí odkaz: https://doaj.org/article/e8855230456c4923a7ca91052e601458