Hallmarks and Molecular Tools for the Study of Mitophagy in Parkinson’s Disease

Autor: Thomas Goiran, Mohamed A. Eldeeb, Cornelia E. Zorca, Edward A. Fon

Publikováno v: Cells, Vol 11, Iss 13, p 2097 (2022)

The best-known hallmarks of Parkinson’s disease (PD) are the motor deficits that result from the degeneration of dopaminergic neurons in the substantia nigra. Dopaminergic neurons are thought to be particularly susceptible to mitochondrial dysfunct

Externí odkaz: https://doaj.org/article/96921f5f50604004810d2945eca004d6

Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology

Autor: Thomas Goiran, Vanessa Alexandra Morais, Mounia Chami, Umut Ozcan, Loan Vaillant Beuchot, Frédéric Checler, Mario Salazar, Han You, Sandra Lacas-Gervais, Wejdane El Manaa, Cristine Alves da Costa, Eric Duplan, Inger Lauritzen, Ling Qi

Publikováno v: Autophagy
article-version (VoR) Version of Record
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a8d439e9d45dea2981a69ca3879574
https://doi.org/10.1080/15548627.2021.1917129

Proteomic Profiling of Mitochondrial-Derived Vesicles in Brain Reveals Enrichment of Respiratory Complex Sub-assemblies and Small TIM Chaperones

Autor: Jean-François Trempe, Andrew N. Bayne, Dominique Lévesque, Rosalind F. Roberts, François-Michel Boisvert, Thomas Goiran, Edward A. Fon

Publikováno v: Journal of proteome research. 20(1)

The generation of mitochondrial-derived vesicles (MDVs) is implicated in a plethora of vital cell functions, from mitochondrial quality control to peroxisomal biogenesis. The discovery of distinct subtypes of MDVs has revealed the selective inclusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29de806e2ec634bed8b5ba640f18f8e0
https://pubmed.ncbi.nlm.nih.gov/33242952

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

Autor: Edward A. Fon, Thomas M. Durcan, Geneviève Dorval, Wei Yi, Carol X.-Q. Chen, Thomas Goiran, Gian-Luca McLelland, Sepideh Valimehr, Nadine D Lauinger, Aleksandar Rakovic, Jean-François Trempe, Andrea I Krahn, Isabelle Rouiller

Publikováno v: eLife, Vol 7 (2018)

Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in mitochondrial quality control pathways remains unexplored. Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7de180535229df5bd79811b0a040c8
https://doi.org/10.7554/elife.32866

Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity

Autor: Y. Marie, Jérôme Honnorat, Eric Duplan, Julien Viotti, J.-Y. Delattre, Thomas Goiran, C Caillava, J Condat, C Giordano, Frédéric Checler, C. Alves da Costa, Ahmed Idbaih

Publikováno v: Oncogene. 33:1764-1775

Gliomas represent the most frequent form of primary brain tumors in adults, the prognosis of which remains extremely poor. Inactivating mutations on the tumor suppressor TP53 were proposed as a key etiological trigger of glioma development. p53 has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06e451e6036dac4a0080e0a68c88598
https://doi.org/10.1038/onc.2013.124