Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Thomas Galbo"'
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27424 (2011)
In type 2 Diabetes (T2D) free fatty acids (FFAs) in plasma are increased and hepatic insulin resistance is "selective", in the sense that the insulin-mediated decrease of glucose production is blunted while insulin's effect on stimulating lipogenesis
Externí odkaz:
https://doaj.org/article/229911b07cce4e168d3d652209507408
Autor:
Florence F. Wagner, Deepika Walpita, Jennifer P. Gale, Noel G. Morgan, Bennett C. Meier, Shrikanta Chattopadhyay, Thomas Mandrup-Poulsen, Tamara J. Gilbert, Amedeo Vetere, Jacob M. Hooker, Taner Kaya, Mélanie Leroy, Sarah J. Richardson, Edward B. Holson, Yan-Ling Zhang, Morten Lundh, Stewart L. Fisher, Thomas Galbo, Patrick McCarren, Bridget K. Wagner, Dan Ploug Christensen
Publikováno v:
ACS Chemical Biology. 11:363-374
Modulation of histone deacetylase (HDAC) activity has been implicated as a potential therapeutic strategy for multiple diseases. However, it has been difficult to dissect the role of individual HDACs due to a lack of selective small-molecule inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97aaaae955cd40727b4ef2db2db7d02
https://doi.org/10.1021/acschembio.5b00640
https://doi.org/10.1021/acschembio.5b00640
Publikováno v:
Diabetes, Obesity and Metabolism. 17:703-707
Failure of pancreatic β cells to compensate for insulin resistance is a prerequisite for the development of type 2 diabetes. Sustained elevated circulating levels of free fatty acids and glucose contribute to β-cell failure. Selective inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad9f80d39e7f9fb2304f1b8d5713194
https://doi.org/10.1111/dom.12470
https://doi.org/10.1111/dom.12470
Autor:
Hui-Young Lee, Varman T. Samuel, Thomas Galbo, Shoichi Kanda, Cheol Soo Choi, Joao Paulo Camporez, Mario Kahn, Andreas L. Birkenfeld, Arijeet K. Gattu, Gerald I. Shulman, Michael J. Jurczak, Zhen Yan, R. Sanders Williams, Dongyan Zhang, François R Jornayvaz, Blas A. Guigni
Publikováno v:
Diabetologia, Vol. 57, No 6 (2014) pp. 1232-1241
Aerobic exercise increases muscle glucose and improves insulin action through numerous pathways, including activation of Ca(2+)/calmodulin-dependent protein kinases (CAMKs) and peroxisome proliferator γ coactivator 1α (PGC-1α). While overexpressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34259ced9f018d76b3fe3a3c2bf2ec14
https://doi.org/10.1007/s00125-014-3212-1
https://doi.org/10.1007/s00125-014-3212-1
Autor:
Donald P. Dione, Albert J. Sinusas, Jennifer L. Cantley, Christopher E. Hall, Daniel F. Vatner, Louis Ragolia, Sanjay Bhanot, Fitsum Guebre-Egziabher, Vara Prasad Manchem, Varman T. Samuel, Max C. Petersen, Thomas Galbo, Arijeet K. Gattu, Mitchel R. Stacy, Rachel J. Perry, Naoki Kumashiro, Jonathan S. Bogan, Anila K. Madiraju
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 307(9)
The steroid receptor coactivator 1 (SRC1) regulates key metabolic pathways, including glucose homeostasis. SRC1−/− mice have decreased hepatic expression of gluconeogenic enzymes and a reduction in the rate of endogenous glucose production (EGP).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b47338af84b8a52a71c3171cf848c7
https://pubmed.ncbi.nlm.nih.gov/25159329
https://pubmed.ncbi.nlm.nih.gov/25159329
Autor:
Varman T. Samuel, Bjørn Quistorff, Thomas Galbo, Gerald I. Shulman, Erica Nishimura, Rachel J. Perry
Publikováno v:
Aging (Albany NY)
In the liver, insulin suppresses hepatic gluconeogenesis by activating Akt, which inactivates the key gluconeogenic transcription factor FoxO1 (Forkhead Box O1). Recent studies have implicated hyperactivity of the Akt phosphatase Protein Phosphatase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ef65cfdefe16a808e2940f8be456e1
https://pubmed.ncbi.nlm.nih.gov/24150286
https://pubmed.ncbi.nlm.nih.gov/24150286
Autor:
Thomas Galbo, Gerald I. Shulman
Publikováno v:
Aging (Albany NY)
The principal function of insulin in the liver is to suppress glucose production when blood glucose concentrations increase. This process is impaired in hepatic insulin resistance and contributes to postprandial hyperglycemia. The development of hepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a737b9e54e1128f1270f14933d3555f9
https://pubmed.ncbi.nlm.nih.gov/23929893
https://pubmed.ncbi.nlm.nih.gov/23929893
Autor:
Blas A. Guigni, Joao Paulo Camporez, Sanjay Bhanot, Varman T. Samuel, Michael J. Jurczak, Julie Serr, Tiago C. Alves, Mario Kahn, Dongyan Zhang, Thomas Galbo, Gerald I. Shulman, Rachel J. Perry
Hepatic insulin resistance is a principal component of type 2 diabetes, but the cellular and molecular mechanisms responsible for its pathogenesis remain unknown. Recent studies have suggested that saturated fatty acids induce hepatic insulin resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5101f991d9247927d3c2d628ea8bd8
https://europepmc.org/articles/PMC3732992/
https://europepmc.org/articles/PMC3732992/
Autor:
Louise Radzikowski, Ole D. Madsen, Klaus H. Kaestner, Anne Ejrnaes Sprinkel, Thomas Galbo, Claude Rescan, Christian J. Stoeckert, Jan N. Jensen, Jan Jensen, Raphael Scharfmann, Gerard Gradwohl, Jonas Ahnfelt-Rønne, Harry Heimberg, Jacob Hald
Publikováno v:
Vrije Universiteit Brussel
The aim of the study was to identify surface bio-markers and corresponding antibody tools that can be used for the imaging and immunoisolation of the pancreatic beta cell and its progenitors. This may prove essential to obtain therapeutic grade human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2123e11027d215cf9a469dcfbf35422
https://pubmed.ncbi.nlm.nih.gov/21947380
https://pubmed.ncbi.nlm.nih.gov/21947380
Autor:
Jacob Hald, Claus Heiner Bang-Berthelsen, Palle Serup, Tina Fløyel, I L Pedersen, Thomas Galbo, Ole D. Madsen
Publikováno v:
European Journal of Histochemistry : EJH
European Journal of Histochemistry, Vol 54, Iss 2, Pp e19-e19 (2010)
European Journal of Histochemistry, Vol 54, Iss 2, Pp e19-e19 (2010)
The aim of this study was to characterize two monoclonal antibodies (F6A11 and F109-D12) generated against Pdx1 (pancreatic and duodenal homeobox-1), a homeodomain transcription factor, which is critical for pancreas formation as well as for normal p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93fd0e5de8ad7772b84e9031808fc38
http://europepmc.org/articles/PMC3167305
http://europepmc.org/articles/PMC3167305