Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas G. Weber"'
Autor:
Florian Kast, Martin Schwill, Jakob C. Stüber, Svende Pfundstein, Gabriela Nagy-Davidescu, Josep M. Monné Rodríguez, Frauke Seehusen, Christian P. Richter, Annemarie Honegger, Karen Patricia Hartmann, Thomas G. Weber, Felix Kroener, Patrick Ernst, Jacob Piehler, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
HER2 acts an oncogenic driver in numerous cancers. Here, the authors design an anti-HER2 biparatopic and tetravalent IgG fusion with inhibitory effects in a xenograft model.
Externí odkaz:
https://doaj.org/article/bbc4cba63fcc425a86335df0941f73d7
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
Supplementary information on cell maintenance, and antibody selection and characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e363db33bfb70119118f019496cf74f
https://doi.org/10.1158/1535-7163.22507438.v1
https://doi.org/10.1158/1535-7163.22507438.v1
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
FAP-drozitumab antibody-mediated apoptosis does not correlate with DR5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3902da6fa0a7fedce1633f385c71997d
https://doi.org/10.1158/1535-7163.22507435.v1
https://doi.org/10.1158/1535-7163.22507435.v1
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
Characterization and optimization of RG7386 dosing in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce9ad07c4aa7036fe31ed07f7a16bea
https://doi.org/10.1158/1535-7163.22507444.v1
https://doi.org/10.1158/1535-7163.22507444.v1
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
Dysregulated cellular apoptosis and resistance to cell death are hallmarks of neoplastic initiation and disease progression. Therefore, the development of agents that overcome apoptosis dysregulation in tumor cells is an attractive therapeutic approa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::494461f0b5e8179b32511522a796418b
https://doi.org/10.1158/1535-7163.c.6538687.v1
https://doi.org/10.1158/1535-7163.c.6538687.v1
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
Figure S2. Related to Figure 3. In vitro characterization of the FAP-DR5 BsAb RG7386; Table S4. Characterization of RG7386 binding avidities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3801c0935929b8b4a51298f3d1fcd860
https://doi.org/10.1158/1535-7163.22507447.v1
https://doi.org/10.1158/1535-7163.22507447.v1
Autor:
Pablo Umaña, Klaus Bosslet, Christian Klein, Suzana Vega-Harring, Gary Xu, Peng Wang, Bin Liu, Cuiying Shao, Hadassah Sade, Werner Scheuer, Frank Herting, Thomas G. Weber, Ekkehard Mössner, Ralf J. Hosse, Sherif Daouti, Ningping Feng, Kathryn Packman, Huifeng Niu, Valeria Runza, Meher Majety, Barbara Weiser, Claudia Ferrara Koller, Inja Waldhauer, Sandra Grau-Richards, Thomas Friess, Katharina Wartha, Peter Brünker
Figure S1. Related to Figure 1. Characterization of FAP-drozitumab BsAbs and antitumor efficacy in the presence of FAP-expressing fibroblasts in in vitro co-culture models; Table S1. BsAb binding to DR5 and FAP antigens; Table S2. Anti-tumor efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c056f1250abf60294a4b98b6735ea39
https://doi.org/10.1158/1535-7163.22507450.v1
https://doi.org/10.1158/1535-7163.22507450.v1
Autor:
Werner Scheuer, Alnawaz Rehemtulla, Stefanie Galbán, Thomas Pöschinger, Anja Renner, Franz Osl, Thomas G. Weber
PDF file - 414KB, Supplementary Figure 2 - Fluorescence imaging after i.v. application of anti-DR5-Cy5 shows no specific antibody accumulation in the right brain hemisphere.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcc0d84f8f48b4f87daa7fa068c6203
https://doi.org/10.1158/0008-5472.22401258
https://doi.org/10.1158/0008-5472.22401258
Autor:
Werner Scheuer, Alnawaz Rehemtulla, Stefanie Galbán, Thomas Pöschinger, Anja Renner, Franz Osl, Thomas G. Weber
High-grade gliomas often possess an impaired blood–brain barrier (BBB), which allows delivery of large molecules to brain tumors. However, achieving optimal drug concentrations in brain tumors remains a significant hurdle for treating patients succ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b18e50aaeb1a76c988b5e0c2d0c73e4
https://doi.org/10.1158/0008-5472.c.6505791
https://doi.org/10.1158/0008-5472.c.6505791