Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thomas G. Metzger"'
Autor:
Rajan Radhakrishnan, Katherine P. Smith, Christine M. Bridgen, Thomas G. Metzger, Jin Zhang, Elizabeth J. Unni, Michael H. DeYoung
Publikováno v:
Currents in Pharmacy Teaching and Learning. 3:192-198
Objective Several studies have found a significant positive association between admission criteria (math/science grade point average [GPA], pharmacy college admission test (PCAT) scores, and having a prior bachelor's degree) and academic performance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f48bed8c8b97aab3fc21f65a85599197
https://doi.org/10.1016/j.cptl.2011.04.006
https://doi.org/10.1016/j.cptl.2011.04.006
Publikováno v:
European Journal of Pharmacology. 538:43-47
The wild type human dopamine transporter (DAT) and five DAT mutants were transfected into COS-7 cells and their ability to uptake dopamine or to bind cocaine was examine three days later. In each mutant, a single charged amino acid, located in areas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d6aa35a1a8489217530487cb65279b
https://doi.org/10.1016/j.ejphar.2006.03.048
https://doi.org/10.1016/j.ejphar.2006.03.048
Autor:
David M. Ferguson, Shiv Kumar Sharma, Philip S. Portoghese, Robert M. Jones, Thomas G. Metzger
Publikováno v:
Journal of Medicinal Chemistry. 44:2073-2079
The importance of the indole scaffold of GNTI 3 in directing its address (5'-guanidinium group) to associate with the Glu297 residue of the kappa-opioid receptor was investigated by the synthesis and biological evaluation of its 4'- (4a), 6'- (4b), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a2f29dcab1fb7c7e3c785ff81e002b
https://doi.org/10.1021/jm010095v
https://doi.org/10.1021/jm010095v
Autor:
William C. Stevens, Thomas G. Metzger, Robert M. Jones, Philip S. Portoghese, David M. Ferguson, Govindan Subramanian
Publikováno v:
Journal of Medicinal Chemistry. 43:2759-2769
The indole moiety in the delta-opioid antagonist, naltrindole (2, NTI), was employed as a scaffold to hold an "address" for interaction with the kappa-opioid receptor. The attachment of the address to the 5'-position of the indole moiety was based on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26046a6ecec2d7ed0d5914171eba03c0
https://doi.org/10.1021/jm0000665
https://doi.org/10.1021/jm0000665
Publikováno v:
Journal of Computational Chemistry. 18:70-79
The gas-phase interaction energies of methane and neopentane dimers are calculated at various intermolecular distances and geometries using several molecular mechanics and semiempirical parameter sets. For comparisons, a set of reference calculations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa32935eb78f59346935e6d268dc8a77
https://doi.org/10.1002/(sici)1096-987x(19970115)18:1<70::aid-jcc7>3.0.co
https://doi.org/10.1002/(sici)1096-987x(19970115)18:1<70::aid-jcc7>3.0.co
Publikováno v:
Journal of Chemical Information and Computer Sciences. 36:857-861
An alignment of the transmembrane domains of halobacterial retinal proteins (including bacteriorhodopsin) and G-protein coupled receptors (GPCRs) is presented based on the commonality of conserved residues between families. Due to the limited sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36492c0e59515fc91c6dbb664421d3a0
https://doi.org/10.1021/ci950360j
https://doi.org/10.1021/ci950360j
Publikováno v:
Journal of Global Optimization. 4:209-227
The conformational space of two protein structures has been examined using a stochastic search method in an effort to locate the global minimum conformation. In order to reduce this optimization problem to a tractable level, we have implemented a sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5818ca10ba1d6eb0f26051808dd7d88a
https://doi.org/10.1007/bf01096723
https://doi.org/10.1007/bf01096723
Publikováno v:
Biochemistry. 44(7)
The first example of the use of a reporter affinity label (NNA) that contains a fluorogenic naphthalene dialdehyde moiety to identify neighboring lysine and cysteine residues at a recognition site is described. The opioid receptors have served as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91bfc09964c5f5753321275ed25dbad
https://pubmed.ncbi.nlm.nih.gov/15709739
https://pubmed.ncbi.nlm.nih.gov/15709739
Autor:
Ping-Yee Law, Christopher R. McCurdy, Philip S. Portoghese, Bertrand Le Bourdonnec, Yan Zhang, Rachid El Kouhen, Thomas G. Metzger
Publikováno v:
Journal of medicinal chemistry. 45(14)
To develop ligands with fluorogenic properties amenable for following the kinetics of cross-linking to receptors, a naphthalene dicarboxaldehyde moiety has been attached to an opiate pharmacophore 2 and evaluated in mu-opioid receptors. The fluoresce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4ba8c6007021a39c284a9973e24684
https://pubmed.ncbi.nlm.nih.gov/12086475
https://pubmed.ncbi.nlm.nih.gov/12086475
Publikováno v:
Protein engineering. 14(12)
Previous studies have probed the structural basis of ligand selectivity in the mu, delta and kappa opioid receptors through the application of molecular modeling techniques in concert with the 'message-address' concept. Here, this approach was used i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9348035f19872da4d77af84942be7e9
https://pubmed.ncbi.nlm.nih.gov/11809925
https://pubmed.ncbi.nlm.nih.gov/11809925