Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Thomas G. Meikle"'
Autor:
Tingting Wang, Habtamu B. Beyene, Changyu Yi, Michelle Cinel, Natalie A. Mellett, Gavriel Olshansky, Thomas G. Meikle, Jingqin Wu, Aleksandar Dakic, Gerald F. Watts, Joseph Hung, Jennie Hui, John Beilby, John Blangero, Rima Kaddurah-Daouk, Agus Salim, Eric K. Moses, Jonathan E. Shaw, Dianna J. Magliano, Kevin Huynh, Corey Giles, Peter J. Meikle
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105199- (2024)
Summary: Background: Metabolic ageing biomarkers may capture the age-related shifts in metabolism, offering a precise representation of an individual’s overall metabolic health. Methods: Utilising comprehensive lipidomic datasets from two large ind
Externí odkaz:
https://doaj.org/article/6698e57fd19a45a9bcec8960081f22cf
Autor:
Habtamu B. Beyene, Kevin Huynh, Tingting Wang, Sudip Paul, Michelle Cinel, Natalie A. Mellett, Gavriel Olshansky, Thomas G. Meikle, Gerald F. Watts, Joseph Hung, Jennie Hui, John Beilby, John Blangero, Eric K. Moses, Jonathan E. Shaw, Dianna J. Magliano, Corey Giles, Peter J. Meikle
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105187- (2024)
Summary: Background: Decreased levels of circulating ethanolamine plasmalogens [PE(P)], and a concurrent increase in phosphatidylethanolamine (PE) are consistently reported in various cardiometabolic conditions. Here we devised, a plasmalogen score (
Externí odkaz:
https://doaj.org/article/6460998e7f29410798ff72ed8d73606f
Autor:
Habtamu B. Beyene, Corey Giles, Kevin Huynh, Tingting Wang, Michelle Cinel, Natalie A. Mellett, Gavriel Olshansky, Thomas G. Meikle, Gerald F. Watts, Joseph Hung, Jennie Hui, Gemma Cadby, John Beilby, John Blangero, Eric K. Moses, Jonathan E. Shaw, Dianna J. Magliano, Peter J. Meikle
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Obesity is a risk factor for type 2 diabetes and cardiovascular disease. However, a substantial proportion of patients with these conditions have a seemingly normal body mass index (BMI). Conversely, not all obese individuals present with me
Externí odkaz:
https://doaj.org/article/c40a6d45d04746158313a34018147a53
Autor:
Blossom Mak, Hui-Ming Lin, Edmond M. Kwan, Heidi Fettke, Ben Tran, Ian D. Davis, Kate Mahon, Martin R. Stockler, Karen Briscoe, Gavin Marx, Alison Zhang, Megan Crumbaker, Winston Tan, Kevin Huynh, Thomas G. Meikle, Natalie A. Mellett, Andrew J. Hoy, Pan Du, Jianjun Yu, Shidong Jia, Anthony M. Joshua, David J. Waugh, Lisa M. Butler, Manish Kohli, Peter J. Meikle, Arun A. Azad, Lisa G. Horvath
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Both changes in circulating lipids represented by a validated poor prognostic 3-lipid signature (3LS) and somatic tumour genetic aberrations are individually associated with worse clinical outcomes in men with metastatic castratio
Externí odkaz:
https://doaj.org/article/0c49ff062a1c4a14adec64ab46d60c0a
Autor:
Hui-Ming Lin, Blossom Mak, Nicole Yeung, Kevin Huynh, Thomas G. Meikle, Natalie A. Mellett, Edmond M. Kwan, Heidi Fettke, Ben Tran, Ian D. Davis, Kate L. Mahon, Alison Zhang, Martin R. Stockler, Karen Briscoe, Gavin Marx, Megan Crumbaker, Phillip D. Stricker, Pan Du, Jianjun Yu, Shidong Jia, Tahlia Scheinberg, Michael Fitzpatrick, Paul Bonnitcha, David R. Sullivan, Anthony M. Joshua, Arun A. Azad, Lisa M. Butler, Peter J. Meikle, Lisa G. Horvath
Publikováno v:
EBioMedicine, Vol 72, Iss , Pp 103625- (2021)
Background: Intrinsic resistance to androgen receptor signalling inhibitors (ARSI) occurs in 20–30% of men with metastatic castration-resistant prostate cancer (mCRPC). Ceramide metabolism may have a role in ARSI resistance. Our study's aim is to i
Externí odkaz:
https://doaj.org/article/9cf94dae05774bb884af7691d010665c
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100127- (2021)
Dysregulation of lipid metabolism plays a major role in the etiology and sequelae of inflammatory disorders, cardiometabolic and neurological diseases, and several forms of cancer. Recent advances in lipidomic methodology allow comprehensive lipidomi
Externí odkaz:
https://doaj.org/article/01261b04f28b41ae8a40f054f0510338
Autor:
Thomas G. Meikle, Arturo Aburto-Medina, Vijayalekshmi Sarojini, Hugh D. Glossop, Céline Valéry, Charlotte E. Conn, Priscila Cardoso
Publikováno v:
Biophysical Reviews
The global public health threat of antimicrobial resistance has led the scientific community to highly engage into research on alternative strategies to the traditional small molecule therapeutics. Here, we review one of the most popular alternatives
Autor:
Jamie B. Strachan, Calum J. Drummond, Charlotte E. Conn, Thomas G. Meikle, Jacinta F. White, Brendan Dyett
Publikováno v:
ACS Applied Materials & Interfaces. 12:6944-6954
Herein, we demonstrate a method for the functionalization of cubic phase lipid nanoparticles (cubosomes) with a series of magnetite (Fe3O4), copper oxide (Cu2O), and silver (Ag) nanocrystals, with prospective applications across a wide range of field
Publikováno v:
BBA Adv
Nuclear magnetic resonance (NMR) spectroscopy is well-established nowadays for the elucidation of the 3D structures of proteins and protein complexes, the evaluation of biomolecular dynamics with atomistic resolution across a range of time scales, th
Publikováno v:
The Journal of chemical physics. 155(22)
The interpretation of molecular translational diffusion as measured by pulsed gradient spin-echo NMR (PGSE NMR) can be complicated by the presence of chemical exchange and/or dipolar cross-relaxation (including relayed cross-relaxation via spin diffu