Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thomas G. Hullinger"'
Autor:
Rusty L. Montgomery, Steven M. Lewton, Brent A Dickinson, Christianna Stack, Anita G. Seto, Hillary M. Semus, Paul Latimer, Thomas G. Hullinger, Joshua M. Lynch, Eva van Rooij
Publikováno v:
European Journal of Heart Failure, 15(6), 650-9. Oxford University Press
AIMS: Recent studies have shown that microRNAs (miRNAs), besides being potent regulators of gene expression, can additionally serve as circulating biomarkers of disease. The aim of this study is to determine if plasma miRNAs can be used as indicators
Publikováno v:
European Journal of Pharmacology. 506:265-271
Leukotrienes and histamine are thought to play important roles in the development of dermatitis. This study evaluated the in vivo efficacy of 5-{4-[(aminocarbonyl)(hydroxy)amino]but-1-ynyl}-2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}e
Autor:
J. P. Meneski, Thomas G. Hullinger, S. M. Crean, Marcelle J. Reilly, Russell S. Taichman, E. H. DeBoever
Publikováno v:
British Journal of Haematology. 124:534-546
Summary Haematopoietic progenitor cells proliferate and develop predominantly when they adhere to bone marrow stromal cells such as osteoblasts. Therefore, changes in adhesion may be a common mechanism by which stem cells survive, mature and properly
Publikováno v:
Journal of Biological Chemistry. 276:46807-46814
Scavenger receptor class B, type I (SR-BI), is a high density lipoprotein receptor that mediates the flux of cholesterol between high density lipoprotein and cells. Recent evidence suggests that SR-BI plays a role in atherosclerosis and that inflamma
Publikováno v:
Experimental Cell Research. 262:69-74
Members of the transforming growth factor superfamily are known to transduce signals via the activation of Smad proteins. Ligand binding to transmembrane cell surface receptors triggers the phosphorylation of pathway-specific Smads. These Smads then
Publikováno v:
Journal of Cellular Biochemistry. 78:607-616
Tumor cells frequently have pronounced effects on the skeleton including bone destruction, bone pain, hypercalcemia, and depletion of bone marrow cells. Despite the serious sequelae associated with skeletal metastasis, the mechanisms by which tumor c
Publikováno v:
The Prostate. 36:14-22
BACKGROUND. Despite the high incidence and serious consequences of skeletal metastasis in prostate cancer patients, the mechanisms involved in establishing secondary lesions in bone are not well-understood. In this study, the role of the mineralized
Autor:
Ronald J. Shebuski, David A. Jones, Jennifer L. Northrup, Carol A. Simmons, Cynthia J. Mills, Thomas G. Hullinger
Publikováno v:
Cardiovascular Research. 32:954-961
Objective: Restenosis is a common problem which limits the effectiveness of percutaneous transluminal coronary angioplasty (PTCA). The cellular mechanisms of restenosis appear to involve smooth muscle cell (SMC) migration to the neointima in response
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 31:153-160
The objective of this investigation was to validate a transit-time ultrasound blood flow metering system in vivo. Implanted chronically and acutely on the ascending aorta of the dog, the transit-time flow probe determined varying flow rates simultane
Autor:
Anita G. Seto, Rusty L. Montgomery, Christianna Stack, Joshua M. Lynch, Joshua M. Hare, Hillary M. Semus, Kathryn Robinson, Paul Latimer, Brent A Dickinson, Christina M. Dalby, Eric N. Olson, Thomas G. Hullinger, Eva van Rooij
Publikováno v:
Circulation research. 110(1)
Rationale: Myocardial infarction (MI) is a leading cause of death worldwide. Because endogenous cardiac repair mechanisms are not sufficient for meaningful tissue regeneration, MI results in loss of cardiac tissue and detrimental remodeling events. M