Výsledky vyhledávání - "Thomas G. Huggins"

Akademický článek

Fine control of metal concentrations is necessary for cells to discern zinc from cobalt

Autor: Deenah Osman, Andrew W. Foster, Junjun Chen, Kotryna Svedaite, Jonathan W. Steed, Elena Lurie-Luke, Thomas G. Huggins, Nigel J. Robinson

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but the binding of metals is not specific in vitro. Here, Osman et al. show that tight regulation of buffered intracellular metal concentrat

Externí odkaz: https://doaj.org/article/8dee7c1b410044ad893a2b322b638933

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Akademický článek

Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells

Autor: Laura R. Sadofsky, Koti T. Sreekrishna, Yakang Lin, Renee Schinaman, Kate Gorka, Yogita Mantri, John Christian Haught, Thomas G. Huggins, Robert J. Isfort, Charles C. Bascom, Alyn H. Morice

Publikováno v: Cells, Vol 3, Iss 2, Pp 616-626 (2014)

Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1 and TRPV1 are often co-expressed in neurons and TRPA1V1 hetero-tetramer formation is noted in

Externí odkaz: https://doaj.org/article/f7c46aceab17406cb71dceaaf20537dd

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Akademický článek

Correction: Sadofsky, L.R., et al. Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells. Cells 2014, 3, 616-626

Autor: Laura R. Sadofsky, Koti T. Sreekrishna, Yakang Lin, Renee Schinaman, Kate Gorka, Yogita Mantri, John Christian Haught, Thomas G. Huggins, Robert J. Isfort, Charles C. Bascom, Alyn H. Morice

Publikováno v: Cells, Vol 3, Iss 4, Pp 994-995 (2014)

The authors wish to make the following corrections to this paper [1]: In Table 2 on page 623, the Quercinitol activation value for TRPA1V1 should be 2.3 instead of 57.6. Quercinitol does not activate TRPA1V1. We thank Michael J.M. Fisher (University

Externí odkaz: https://doaj.org/article/e45f8b82b5234571b2658c4178969a46

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Biomarkers of neonatal skin barrier adaptation reveal substantial differences compared to adult skin

Autor: Marty O. Visscher, Jason M. Winget, Vivek Narendran, Charles C. Bascom, Andrew N. Carr, Robert J. Isfort, Karen Lammers, Thomas G. Huggins

Publikováno v: Pediatric Research

BackgroundThe objective of this study was to measure skin characteristics in premature (PT), late preterm (LPT), and full-term (FT) neonates compared with adults at two times (T1, T2).MethodsSkin samples of 61 neonates and 34 adults were analyzed for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9c1789505fd741508c172525b8465d
https://pubmed.ncbi.nlm.nih.gov/32929185

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Bacterial sensors define intracellular free energies for correct enzyme metalation

Autor: Maria Alessandra Martini, Nigel J. Robinson, Martin J. Warren, Peter T. Chivers, Andrew J. P. Scott, Thomas G. Huggins, Deenah Osman, Evelyne Deery, Richard Morton, Elena Lurie-Luke, Andrew W. Foster, Jonathan W. Steed, Junjun Chen, Andy Lawrence

Publikováno v: Nature chemical biology
Nature chemical biology, 2019, Vol.15(3), pp.241-249 [Peer Reviewed Journal]

There is a challenge for metalloenzymes to acquire their correct metals because some inorganic elements form more stable complexes with proteins than do others. These preferences can be overcome provided some metals are more available than others. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67ed230a7e708ff5c078069f59b8e24

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Fine control of metal concentrations is necessary for cells to discern zinc from cobalt

Autor: Andrew W. Foster, Jonathan W. Steed, Elena Lurie-Luke, Deenah Osman, Thomas G. Huggins, Junjun Chen, Nigel J. Robinson, Kotryna Svedaite

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature communications, 2017, Vol.8, pp.1884 [Peer Reviewed Journal]
Nature Communications

Bacteria possess transcription factors whose DNA-binding activity is altered upon binding to specific metals, but metal binding is not specific in vitro. Here we show that tight regulation of buffered intracellular metal concentrations is a prerequis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35e3fd24634a805419ffa938098722b
https://doi.org/10.1038/s41467-017-02085-z

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Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells

Autor: Yakang Lin, Koti Tatachar Sreekrishna, Alyn H. Morice, Robert J. Isfort, Charles C. Bascom, John Christian Haught, Renee Schinaman, Laura R. Sadofsky, Thomas G. Huggins, Yogita Mantri, Kate Gorka

Publikováno v: Cells, Vol 3, Iss 2, Pp 616-626 (2014)
Cells
Cells; Volume 3; Issue 2; Pages: 616-626

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e173263ea0db53acff2612311da1d3
http://www.mdpi.com/2073-4409/3/2/616

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Trace Analysis of Bromate in Potato Snacks Using High-Performance Liquid Chromatography−Tandem Mass Spectrometry

Autor: Francisco Arias, Kenneth R. Wehmeyer, Thomas G. Huggins, Lijuan Li, Paul R. Keller, Paula M. Suchanek

Publikováno v: Journal of Agricultural and Food Chemistry. 58:8134-8138

A simple, sensitive, and selective high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method in the negative-ion electrospray ionization (ESI(-)) mode was validated for the quantitation of bromate (BrO(3)(-)) in potato snack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a255a38f52ddf3f78aacb16b8c1e3a34
https://doi.org/10.1021/jf902732e

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Conference Report: 10th Annual University of Wisconsin Land O’Lakes Bioanalytical Conference

Autor: Qin C Ji, Douglas J Turk, Brian Booth, Mark E. Arnold, Michael Hayes, Russell Grant, Eric Fluhler, Thomas G. Huggins, James E DeMuth

Publikováno v: Bioanalysis. 1:1397-1401

This conference was arranged by the Extension Services in Pharmacy at the University of Wisconsin School of Pharmacy. The purpose of this annual 4-day conference is to provide an educational forum to discuss issues and applications associated with th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3febbff41256be753bcbabac498f2f9
https://doi.org/10.4155/bio.09.125

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Formation of o-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation

Autor: Mary C. Wells-Knecht, Thomas G. Huggins, Suzanna R. Thorpe, Nicholas A. Detorie, John W. Baynes

Publikováno v: Journal of Biological Chemistry. 268:12341-12347

To evaluate their usefulness as chemical indicators of cumulative oxidative damage to proteins, we studied the kinetics and extent of formation of ortho-tyrosine (o-Tyr), dityrosine (DT), and dityrosine-like fluorescence (Ex = 317 nm, Em = 407 nm) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5da639845cd8fa598711d5b5f16a5db9
https://doi.org/10.1016/s0021-9258(18)31395-4

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