Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Thomas G. Hennings"'
Autor:
Ronan Russell, Phichitpol P. Carnese, Thomas G. Hennings, Emily M. Walker, Holger A. Russ, Jennifer S. Liu, Simone Giacometti, Roland Stein, Matthias Hebrok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The MAF bZIP transcription factor B (MAFB) is present in postnatal human beta cells but its role is unclear. Here, the authors show that MAFB regulates endocrine pancreatic cell fate specification.
Externí odkaz:
https://doaj.org/article/e0d2c3d6cf86401bb280695fe609017c
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports, vol 10, iss 1
Gpr27 is a highly conserved, orphan G protein coupled receptor (GPCR) previously implicated in pancreatic beta cell insulin transcription and glucose-stimulated insulin secretion in vitro. Here, we characterize a whole-body mouse knockout of Gpr27. G
Autor:
Thomas G. Hennings, Deeksha Gambhir Chopra, Kenny K. H. Ang, Gregory M. Ku, Michael S. German, Ian W. Vaughn, Justin J Choe, Michelle R. Arkin, Christopher Lan, Michael T. McManus, Jessica M. Lee, Zachary Pappalardo, Steven Chen
Publikováno v:
Endocrinology. 159:3321-3330
Insulin production by the pancreatic β cell is critical for the glucose homeostasis of the whole organism. Although the transcription factors required for insulin production are known, the upstream pathways that control insulin production are less c
Autor:
Thomas G. Hennings, Jennifer S. Liu, Roland Stein, Ronan Russell, Simone Giacometti, Emily M. Walker, Phichitpol P. Carnese, Holger A. Russ, Matthias Hebrok
Publikováno v:
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, vol 11, iss 1
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, vol 11, iss 1
Next generation sequencing studies have highlighted discrepancies in β-cells which exist between mice and men. Numerous reports have identified MAF BZIP Transcription Factor B (MAFB) to be present in human β-cells postnatally, while its expression
Autor:
Holger A Russ, Audrey V Parent, Jennifer J Ringler, Thomas G Hennings, Gopika G Nair, Mayya Shveygert, Tingxia Guo, Sapna Puri, Leena Haataja, Vincenzo Cirulli, Robert Blelloch, Greg L Szot, Peter Arvan, Matthias Hebrok
Publikováno v:
The EMBO Journal. 34:1759-1772
Methods are provided for the simple, fast, effective and safe directed differentiation of embryonic stem cells into pancreatic beta-like cells secreting insulin in response to glucose levels. The cells are useful transplant therapeutics for diabetic
Autor:
Michael S. German, Justin J Choe, Michael T. McManus, Deeksha Gambhir Chopra, Steven Chen, Hunter Richards, Katherine Yang, Zachary Pappalardo, Kenny K. H. Ang, Michelle R. Arkin, Gregory M. Ku, Luc Baeyens, Thomas G. Hennings
Publikováno v:
Diabetes, vol 66, iss 6
Diabetes
Diabetes
Insulin production by the pancreatic β-cell is required for normal glucose homeostasis. While key transcription factors that bind to the insulin promoter are known, relatively little is known about the upstream regulators of insulin transcription. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfbbe6f1b871f76d45643f3f3e2aa33
https://escholarship.org/uc/item/6js6r6p4
https://escholarship.org/uc/item/6js6r6p4