Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thomas G. Hazel"'
Autor:
Guangzhu Zhang, Ying Li, James L. Reuss, Nan Liu, Cuiying Wu, Jingpo Li, Shuangshuang Xu, Feng Wang, Thomas G. Hazel, Miles Cunningham, Hongtian Zhang, Yiwu Dai, Peng Hong, Ping Zhang, Jianghong He, Huiru Feng, Xiangdong Lu, John L. Ulmer, Karl K. Johe, Ruxiang Xu
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 10, Pp 999-1007 (2019)
Abstract NSI‐566 is a stable, primary adherent neural stem cell line derived from a single human fetal spinal cord and expanded epigenetically with no genetic modification. This cell line is being tested in clinical trials in the U.S. for treatment
Externí odkaz:
https://doaj.org/article/112c941a54514a309226862fde02f5f4
Publikováno v:
Cell Transplantation, Vol 23 (2014)
Treatment of central nervous system (CNS) malignancies typically involves radiotherapy to forestall tumor growth and recurrence following surgical resection. Despite the many benefits of cranial radiotherapy, survivors often suffer from a wide range
Externí odkaz:
https://doaj.org/article/a38a4452d72649958c35b8a531901062
Autor:
John L. Ulmer, GuangZhu Zhang, Feng Wang, Karl Johe, Ying Li, Miles G. Cunningham, Huiru Feng, Ruxiang Xu, Yiwu Dai, Ping Zhang, Xiangdong Lu, Peng Hong, Nan Liu, Jianghong He, James L. Reuss, Jingpo Li, Hongtian Zhang, Shuangshuang Xu, Cuiying Wu, Thomas G. Hazel
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 10, Pp 999-1007 (2019)
Stem Cells Translational Medicine
Stem Cells Translational Medicine
NSI-566 is a stable, primary adherent neural stem cell line derived from a single human fetal spinal cord and expanded epigenetically with no genetic modification. This cell line is being tested in clinical trials in the U.S. for treatment of amyotro
Autor:
Naoki Tajiri, David M Quach, Yuji Kaneko, Stephanie Wu, David Lee, Tina Lam, Ken L Hayama, Thomas G Hazel, Karl Johe, Michael C Wu, Cesar V Borlongan
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91408 (2014)
Stroke is a major cause of death and disability, with very limited treatment option. Cell-based therapies have emerged as potential treatments for stroke. Indeed, studies have shown that transplantation of neural stem cells (NSCs) exerts functional b
Externí odkaz:
https://doaj.org/article/414b27477b7044cf9c7503f5e32057af
Autor:
Markus S. Spurlock, Deborah A. Shear, Stephanie W. Lee, Aminul I. Ahmed, Pingdewinde N. Sam, Karl Johe, Michael P. Hefferan, Frank C. Tortella, Karla N. Rivera, Ross Bullock, Shyam Gajavelli, Shoji Yokobori, Thomas G. Hazel
Publikováno v:
Journal of Neurotrauma. 34:1981-1995
Penetrating traumatic brain injury (PTBI) is one of the major cause of death and disability worldwide. Previous studies with penetrating ballistic-like brain injury (PBBI), a PTBI rat model revealed widespread perilesional neurodegeneration, similar
Autor:
Naoki Tajiri, David M. Quach, Yuji Kaneko, Thomas G. Hazel, Stephanie C Wu, Michael C. Wu, Ken L. Hayama, Karl Johe, Tina Lam, David Lee, Cesar V. Borlongan
Publikováno v:
Journal of Cellular Physiology
Enhancing neurogenesis may be a powerful stroke therapy. Here, we tested in a rat model of ischemic stroke the beneficial effects of NSI‐189, an orally active, new molecular entity (mol. wt. 366) with enhanced neurogenic activity, and indicated as
Autor:
Thomas G. Hazel, Ping Zhang, Miles G. Cunningham, Guang-Zhi Ge, BeiBei Wang, Yiwu Dai, MiaoChun Bai, Karl Johe, Ruxiang Xu, Hongtian Zhang, GuangZhu Zhang
Publikováno v:
Operative neurosurgery (Hagerstown, Md.). 18(5)
Background In preclinical studies, the Intracerebral Microinjection Instrument (IMI) has demonstrated the ability to deliver therapeutics within the brain in 3-dimensional arrays from a single overlying penetration while incurring minimal localized t
Autor:
Michael P. Hefferan, Karl Johe, Thomas G. Hazel, Martin Marsala, Eva L. Feldman, J. Simon Lunn
Publikováno v:
Cell Transplantation, Vol 20 (2011)
Previous rodent studies employing monotherapy or combined immunosuppressive regimens have demonstrated a variable degree of spinal xenograft survival in several spinal neurodegenerative models including spinal ischemia, trauma, or amyotrophic lateral
Publikováno v:
Neuroscience Letters. 494:222-226
Stem cells provide novel sources of cell therapies for motor neuron disease that have recently entered clinical trials. In the present study, we transplanted human neural stem cells (NSCs) into the ventral horn of both the lumbar (L4-L5) and cervical
Autor:
Jun Yan, Leyan Xu, Glen Hatfield, Karl Johe, David Chen, Annie M. Welsh, Thomas G. Hazel, Vassilis E. Koliatsos
Publikováno v:
Transplantation. 82:865-875
Background Experimental therapeutics for degenerative and traumatic diseases of the nervous system have been recently enriched with the addition of neural stem cells (NSCs) as alternatives to fetal tissues for cell replacement. Neurodegenerative dise