Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Thomas G. Griffiths"'
Autor:
Stephen Pacchione, Amy B. Barnum, Jayanthi J. Wolf, Philip J. Troilo, Thomas G. Griffiths, Cindy Pauley, B J Ledwith, Laural B. Harper, Zhibin Wang, José A. Lebrón
Publikováno v:
Gene Therapy. 29:322-332
While generally referred to as "non-integrating" vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate (nonhomologous) recombination. The present study provides a quantitative assessment of the potential i
Autor:
José A. Lebrón, Kaushik Mitra, Keith Q. Tanis, Thomas G. Griffiths, Stephen Pacchione, Matthew Kuhls, Ian Knemeyer, Donald J Marsh, Wen Kang, Frank D. Sistare, Zhibin Wang, Qing Chen, Kimberly B. Bleicher, Ming Su, George M. Laws, Alexei A. Podtelezhnikov
Publikováno v:
Toxicological Sciences. 177:121-139
Early risk assessment of drug-induced liver injury (DILI) potential for drug candidates remains a major challenge for pharmaceutical development. We have previously developed a set of rat liver transcriptional biomarkers in short-term toxicity studie
Autor:
Zhibin, Wang, Philip J, Troilo, Thomas G, Griffiths, Laural B, Harper, Amy B, Barnum, Stephen J, Pacchione, Cindy J, Pauley, Jose A, Lebron, Jayanthi, Wolf, Brian J, Ledwith
Publikováno v:
Gene therapy. 29(6)
While generally referred to as "non-integrating" vectors, adenovirus vectors have the potential to integrate into host DNA via random, illegitimate (nonhomologous) recombination. The present study provides a quantitative assessment of the potential i
Autor:
José A. Lebrón, Frank D. Sistare, Qing Chen, Donald J Marsh, Matthew Kuhls, Timothy E. Johnson, Wen Kang, Zhibin Wang, George Laws, Kaushik Mitra, James J. Monroe, Keith Q. Tanis, Thomas G. Griffiths, Kimberly B. Bleicher, Ming Su, Alexei A. Podtelezhnikov, Stephen Pacchione, Ian Knemeyer
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S42
Autor:
Zhutian Niu, Thomas G. Griffiths, Krista L. Striano, Zhibin Wang, Stephen Pacchione, José A. Lebrón, Jayanthi J. Wolf, Philip J. Troilo
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 63:174-179
Introduction Various animal models are routinely used to evaluate the efficacy and toxicity of small interfering RNA (siRNA) therapeutics. Given that the most common measure of efficacy with siRNA therapeutics is mRNA knockdown, the development of a
Autor:
Izhack Hemo, Eithan Galun, Zhutian Niu, Gideon Zamir, Orit Papo, Ofer Nussbaum, Dana F. Roden, Philip J. Troilo, Zakharia Manevitch, Michal Gropp, Evelyne Zeira, Rimma Barsuk, Nili Daudi, Stephen Pacchione, Alexandra Manevitch, Thomas G. Griffiths, Aaron Lewis, Hagit Yotvat, Menahem Harati, Eli Kedar
Publikováno v:
The FASEB Journal. 21:3522-3533
A femtosecond laser beam gene transduction (SG-LBGT) system is described as a novel and efficient method of intradermal (i.d.) nonviral gene delivery in mice by permeabilizing cells utilizing femtosecond laser pulses. Using this approach, significant
Autor:
Cindy J. Pauley, Warren W. Nichols, Carolann M. Beare, Amy B. Barnum, Sujata Manam, Walter J. Bagdon, Philip J. Troilo, Brian J. Ledwith, Laural B. Harper, Thomas G. Griffiths
Publikováno v:
Intervirology. 43:258-272
The primary safety concern for DNA vaccines is their potential to integrate into the host cell genome. We describe an integration assay based on purification of high-molecular-weight genomic DNA away from free plasmid using gel electrophoresis, such
Autor:
Zhibin Wang, Warren W. Nichols, Laural B. Harper, Walter J. Bagdon, Thomas G. Griffiths, B J Ledwith, Lyudmila Denisova, Philip J. Troilo, Zhutian Niu, Thy T. Follmer, Amy B. Barnum, Sujata Manam, Carolann M. Beare, Stephen Pacchione, Cindy J. Pauley
Publikováno v:
Intervirology. 43:273-281
A variety of factors could affect the frequency of integration of plasmid DNA vaccines into host cellular DNA, including DNA sequences within the plasmid, the expressed gene product (antigen), the formulation, delivery method, route of administration
Autor:
T T Follmer, Cindy J. Pauley, S J Pacchione, Brian J. Ledwith, Gabriella Rizzuto, Elena Fattori, Zhibin Wang, Nicola La Monica, Gennaro Ciliberto, X Wang, Thomas G. Griffiths, A B Barnum, Sujata Manam, L Denisova, L B Harper, Z Niu, Philip Troilo
Publikováno v:
Gene therapy. 11(8)
Plasmid vectors have been widely used for DNA vaccines and gene therapy. Following intramuscular injection, the plasmid that persists is extrachromosomal and integration into host DNA, if it occurs at all, is negligible. However, new technologies for
Autor:
Amy B. Barnum, Sergey N. Kochetkov, N. Tordo, Gösta Winberg, H.P. Hefti, Natalia N. Petrakova, Minchao Chen, Zhibin Wang, Sujata Manam, Maria G. Isaguliants, J. Schultz, Jeffrey B. Ulmer, Dan H. Barouch, B. Hejdeman, Jeong-Im Sin, Stephen J. Pacchione, Fengfeng Xu, Mei Hong, P. Perrin, Karin Mölling, R. Z. Gizatullin, Thomas G. Griffiths, Carolann M. Beare, Katja Pokrovskaya, Mark J. Selby, Anne Kjerrström, Cindy J. Pauley, E. Operschall, Laural B. Harper, Zhutian Niu, Bartek Zuber, Warren W. Nichols, D. A. Kostyuk, Mary Schaefer, Gillis R. Otten, B. Wahren, Tong Wu, Cheryl Goldbeck, T. Schuh, David B. Weiner, Britta Wahren, Y. Jacob, Thy T. Follmer, Klaus Cichutek, K. Mölling, Walter J. Bagdon, A.L. Hultström, Brian J. Ledwith, Michael J. McCluskie, Jorma Hinkula, Lyudmila Denisova, G. Bratt, Günter Dollenmaier, Barbara Doe, Lacrimiora Comanita, Philip J. Troilo, Jan Schultz, J. Pavlovic, Norman L. Letvin, Risini D. Weeratna, Kenneth Lundstrom, M. Nawrath, E. Carbone, Heather L. Davis, A.C. Leandersson
Publikováno v:
Intervirology. 43:343-344