Výsledky vyhledávání - "Thomas G. Burdon"

Tuning of β-catenin activity is required to stabilize self-renewal of rat embryonic stem cells

Autor: Linda Sutherland, Simon R. Tomlinson, Mia Buehr, Stephen Meek, Thomas G. Burdon, Jun Wei, Alison Thomson, Benedikt S. Nilges

Publikováno v: STEM CELLS; Vol 31

Stabilization of β-catenin, through inhibition of glycogen synthase kinase 3 (GSK3) activity, in conjunction with inhibition of mitogen-activated protein kinase kinase 1/2 (MEK) promotes self-renewal of naïve-type mouse embryonic stem cells (ESC).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49511a3c04abdde8bc019de5b111efe6
https://doi.org/10.1002/stem.1466

Zobrazit plný text záznamu

The proximal milk protein binding factor binding site is required for the prolactin responsiveness of the sheep β-lactoglobulin promoter in Chinese hamster ovary cells

Autor: Thomas G. Burdon, A. John Clark, Christine J. Watson, Jean Djiane, Jerome Demmer

Publikováno v: Molecular and Cellular Endocrinology. 107:113-121

To identify cis-acting prolactin (PRL) response elements within the sheep β-lactoglobulin (BLG) promoter, CHO cells were cotransfected with a rabbit PRL-receptor (PRL-R) expression plasmid and a number of BLG-CAT constructs. Resection through the 42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf4c9dc48dac825b600f89276a6239f
https://doi.org/10.1016/0303-7207(94)03432-s

Zobrazit plný text záznamu

Regulation of the sheep beta-lactoglobulin gene by lactogenic hormones is mediated by a transcription factor that binds an interferon-gamma activation site-related element

Autor: R Wallace, A J Clark, K A Maitland, Christine J. Watson, Thomas G. Burdon

Publikováno v: Molecular Endocrinology. 8:1528-1536

Polypeptide and steroid hormones regulate the transcription of milk protein genes in the mammary gland. The promoter sequence motifs and factors through which these hormones mediate their effects in vivo are not clearly defined. Milk protein binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde27adf3f0b1d2f0fa0c155fa48dd61
https://doi.org/10.1210/mend.8.11.7877621

Zobrazit plný text záznamu

The mammary factor MPBF is a prolactin-induced transcriptional regulator which binds to STAT factor recognition sites

Autor: Thomas G. Burdon, Christine J. Watson, A. John Clark, Jerome Demmer

Publikováno v: Burdon, T, Demmer, J, Clark, A J & Watson, C J 1994, ' The mammary factor MPBF is a prolactin-induced transcriptional regulator which binds to STAT factor recognition sites ', FEBS Letters, vol. 350, no. 2-3, pp. 177-82 .

Site-directed mutagenesis of the three binding sites for the mammary factor MPBF in the β-lactoglobulin (BLG) promoter demonstrates that MPBF is a transcriptional activator of the BLG gene in mammary cells. MPBF requires phosphorylation on tyrosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a3e5eceb3331d9bff0b35aa157b971
https://doi.org/10.1016/0014-5793(94)00757-8

Zobrazit plný text záznamu

Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent

Autor: Colin Farquharson, Vicky E MacRae, Thomas G. Burdon, Syed Faisal Ahmed

Publikováno v: MacRae, V E, Burdon, T, Ahmed, S F & Farquharson, C 2006, ' Ceramide inhibition of chondrocyte proliferation and bone growth is IGF-I independent ', Journal of Endocrinology, vol. 191, no. 2, pp. 369-77 . https://doi.org/10.1677/joe.1.06958

Proinflammatory cytokines inhibit growth plate development. However, their underlying mechanisms of action are unclear. These effects may be mediated by ceramide, a sphingosine-based lipid second messenger, which is elevated in a number of chronic in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d096a5c3b12eb5c4285834b6807b317
https://pubmed.ncbi.nlm.nih.gov/17088406

Zobrazit plný text záznamu

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Autor: Wasco Wruck, Detlef Groth, Thore C. Brink, Yasmin Babaie, Ralf Herwig, Boris Greber, James Adjaye, Thomas G. Burdon, Hans Lehrach

Publikováno v: Stem Cells

The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64cbffe0419a484c8de9d6b129f53bfd
https://hdl.handle.net/11858/00-001M-0000-0010-836D-011858/00-001M-0000-0010-836C-1

Zobrazit plný text záznamu

Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

Autor: Bart Vanhaesebroeck, Paul G. Tiffen, Tomoichiro Asano, Thomas G. Burdon, Antonio Bilancio, Kathrine Abell, Christine J. Watson, Anton I. Altaparmakov, Richard W. E. Clarkson

Physiological apoptosis is induced by a switch from survival to death signalling. Dysregulation of this process is frequently associated with cancer. A powerful model for this apoptotic switch is mammary gland involution, during which redundant milk-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9e633db14662b42f25945e8f4860c5
http://hdl.handle.net/11591/185885

Zobrazit plný text záznamu

Oct-4 knockdown induces similar patterns of endoderm and trophoblast differentiation markers in human and mouse embryonic stem cells

Autor: Linda Sutherland, Thomas G. Burdon, John Clark, David C. Hay

Publikováno v: Stem cells (Dayton, Ohio). 22(2)

The transcription factor Oct-4 is a marker of pluripotency in mouse and human embryonic stem (ES) cells. Previous studies using a tetracycline-regulated Oct-4 transgene in the ZHBTc4 cell line demonstrated that downregulation of Oct-4 expression indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0754036e2c00031d211332f94e862dd8
https://pubmed.ncbi.nlm.nih.gov/14990861

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání