Zobrazeno 1 - 10
of 405
pro vyhledávání: '"Thomas G. Back"'
Publikováno v:
Molecules, Vol 29, Iss 20, p 4915 (2024)
Selenoxide syn elimination is a widely used method for the synthesis of alkenes because it proceeds under exceptionally mild conditions, typically with excellent regio- and stereoselectivity. Surprisingly, hetero-selenoxide eliminations, where one or
Externí odkaz:
https://doaj.org/article/afaad98a666341cb9cc9efe78a2c9a6a
Publikováno v:
Molecules, Vol 28, Iss 9, p 3732 (2023)
The antioxidant drug ebselen has been widely studied in both laboratories and in clinical trials. The catalytic mechanism by which it destroys hydrogen peroxide via reduction with glutathione or other thiols is complex and has been the subject of con
Externí odkaz:
https://doaj.org/article/d726cc81c19e45ccb1f7d1d4390301f2
Autor:
Jinjing Yao, Mingke Ni, Shanshan Tian, Bo Sun, Ruiwu Wang, John Paul Estillore, Thomas G. Back, S.R. Wayne Chen
Publikováno v:
Neuroscience. 522:11-22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d908df018cf5c0701936c93d482d0a4a
https://doi.org/10.1016/j.neuroscience.2023.04.031
https://doi.org/10.1016/j.neuroscience.2023.04.031
Autor:
Jinjing Yao, Bo Sun, Adam Institoris, Xiaoqin Zhan, Wenting Guo, Zhenpeng Song, Yajing Liu, Florian Hiess, Andrew K.J. Boyce, Mingke Ni, Ruiwu Wang, Henk ter Keurs, Thomas G. Back, Michael Fill, Roger J. Thompson, Ray W. Turner, Grant R. Gordon, S.R. Wayne Chen
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108169- (2020)
Summary: Neuronal hyperactivity is an early primary dysfunction in Alzheimer’s disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously unknown mode
Externí odkaz:
https://doaj.org/article/f1542ee57d16493dbb99194c8f285f27
Publikováno v:
ACS Omega. 7:27312-27323
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18eff9a27fbec04d21f053bcc7594978
https://doi.org/10.1021/acsomega.2c02286
https://doi.org/10.1021/acsomega.2c02286
Autor:
Thomas G. Back
Publikováno v:
Chalcogen Chemistry: Fundamentals and Applications ISBN: 9781839164224
The redox properties of selenium enable a diverse range of synthetically useful and often unique reactions. These processes typically require stoichiometric amounts of selenium reagents, but more recent catalytic versions employing appropriate co-oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65f658acf87b203ff19795af6af8fa1f
https://doi.org/10.1039/bk9781839167386-00334
https://doi.org/10.1039/bk9781839167386-00334
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 10748-10762 (2015)
Cyclic seleninate esters function as mimetics of the antioxidant selenoenzyme glutathione peroxidase. They catalyze the reduction of harmful peroxides with thiols, which are converted to disulfides in the process. The possibility that the seleninate
Externí odkaz:
https://doaj.org/article/cb7f4239bfce449da7d94f77772113a9
Publikováno v:
Angewandte Chemie International Edition. 61
During attempts to prepare spirodithiaselenuranes as GPx mimetics, a series of unexpected dimeric macrocycles was obtained, each containing two selenide and two disulfide moieties in rings ranging from 18- to 26-membered. The products showed potent G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d8f1c859946d2469c9b8c7c3ee8293
https://doi.org/10.1002/anie.202213744
https://doi.org/10.1002/anie.202213744
Autor:
Zhenpeng Song, Wenting Guo, Jinjing Yao, Thomas G. Back, S.R. Wayne Chen, Bo Sun, Yajing Liu, John Paul Estillore, Jinhong Wei
Publikováno v:
Journal of Neuroscience Research. 99:2906-2921
Increasing evidence suggests that Alzheimer's disease (AD) progression is driven by a vicious cycle of soluble β-amyloid (Aβ)-induced neuronal hyperactivity. Thus, breaking this vicious cycle by suppressing neuronal hyperactivity may represent a lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef79387757fc1c92c04637815af60fb7
https://doi.org/10.1002/jnr.24936
https://doi.org/10.1002/jnr.24936
Publikováno v:
The Journal of Organic Chemistry. 86:9938-9944
The synthesis of aryl selenonic acids was achieved from diverse aryl bromides via a one-pot method involving metalation, selenation, and oxidation with hydrogen peroxide followed by ion exchange to afford the pure products in 77-90% yield. An o-hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98aa50c9d4dde0220b5e2eaee0f585e7
https://doi.org/10.1021/acs.joc.1c01369
https://doi.org/10.1021/acs.joc.1c01369