Zobrazeno 1 - 10
of 1 028
pro vyhledávání: '"Thomas G Scott"'
Publikováno v:
PLoS Genetics, Vol 20, Iss 2, p e1011159 (2024)
Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout. We introduced an inducible degron t
Externí odkaz:
https://doaj.org/article/1ea7745be3074667b30911fbb237b595
Autor:
Sylwia Hasterok, Thomas G. Scott, Devin G. Roller, Adam Spencer, Arun B. Dutta, Kizhakke M Sathyan, Daniel E. Frigo, Michael J. Guertin, Daniel Gioeli
The clinical success of combined androgen deprivation therapy (ADT) and radiation therapy (RT) in prostate cancer (PCa) created interest in understanding the mechanistic links between androgen receptor (AR) signaling and the DNA damage response (DDR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c389664a3c8cb66537286b0269663bc4
https://doi.org/10.1101/2023.05.13.540653
https://doi.org/10.1101/2023.05.13.540653
Autor:
James E. Bradner, George D. Demetri, Scott A. Armstrong, Ewa Sicinska, Chandrajit P. Raut, Thomas G. Scott, Otari Chipashvili, Timothy Hagan, Jessica L. Andersen, Matthew A. Lawlor, Matthew L. Hemming
Gastrointestinal stromal tumor (GIST) is a mesenchymal neoplasm characterized by activating mutations in the related receptor tyrosine kinases KIT and PDGFRA. GIST relies on expression of these unamplified receptor tyrosine kinase (RTK) genes through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892a37a37a39293056fb095a998fdb8b
https://doi.org/10.1158/0008-5472.c.6511217
https://doi.org/10.1158/0008-5472.c.6511217
Autor:
James E. Bradner, George D. Demetri, Scott A. Armstrong, Ewa Sicinska, Chandrajit P. Raut, Thomas G. Scott, Otari Chipashvili, Timothy Hagan, Jessica L. Andersen, Matthew A. Lawlor, Matthew L. Hemming
Figure S1. Evaluation of the KIT locus in GIST cell lines. Figure S2. Effect of imatinib and JQ1 treatment on cell cycle and apoptosis in GIST cell lines. Figure S3. Effect of JQ1 and imatinib on KIT mRNA, protein and signaling. Figure S4. KIT rescue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03258fc4ecf97157d679b287abc5c87b
https://doi.org/10.1158/0008-5472.22422422
https://doi.org/10.1158/0008-5472.22422422
Precision genomic run-on assays (PRO-seq) quantify nascent RNA at single nucleotide resolution with strand specificity. Here we deconstruct a recently published genomic nascent RNA processing pipeline (PEPPRO) into its components and link the analyse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af106fa48f2c71d0657ee1bf3ac2ba0
https://doi.org/10.1101/2022.12.14.520463
https://doi.org/10.1101/2022.12.14.520463
Autor:
Otari Chipashvili, Matthew L. Hemming, Matthew A. Lawlor, Ewa Sicinska, Chandrajit P. Raut, Thomas G. Scott, George D. Demetri, James E. Bradner, Timothy Hagan, Jessica L. Andersen, Scott A. Armstrong
Publikováno v:
Cancer Research. 79:994-1009
Gastrointestinal stromal tumor (GIST) is a mesenchymal neoplasm characterized by activating mutations in the related receptor tyrosine kinases KIT and PDGFRA. GIST relies on expression of these unamplified receptor tyrosine kinase (RTK) genes through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383df6a5d8fa1d5db6398823b844b575
https://doi.org/10.1158/0008-5472.can-18-1888
https://doi.org/10.1158/0008-5472.can-18-1888
Autor:
Joe Sahil Patel, Eunice S. Park, Chi-Li Chen, Andrew J. K. Phillips, Linda Lee, Thomas G. Scott, Christina S. Henderson, Ashley A. Hart, David A. Proia, James A. Henderson, W. Austin Elam, Catherine S. Oakes, Trang N. Tieu, Joelle Baddour, Mark C. Norley, Mathew E. Sowa, Jessica Freda, Marius S. Pop, Brendon Ladd, Minsheng He, Christopher G. Nasveschuk, Harit U. Vora, Gunther Kern, Gesine Kerstin Veits, Abigail Vogelaar, Stewart L. Fisher, Richard W. Deibler, Rhamy Zeid, Mark W. Carlson, Roman V. Agafonov, Arushi Jain, Graham P. Marsh, Prasoon Chaturvedi, Hannah J. Maple, Scott J. Eron, Emily S. Kibbler
Publikováno v:
Current Research in Chemical Biology, Vol 1, Iss, Pp 100010-(2021)
In addition to the therapeutic applicability of targeted protein degradation (TPD), the modality also harbors unique properties that enable the development of innovative chemical biology tools to interrogate complex biology. TPD offers an all-chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fae8825e77dd3f8f25ec2a5b2702cc
http://www.sciencedirect.com/science/article/pii/S2666246921000100
http://www.sciencedirect.com/science/article/pii/S2666246921000100