Výsledky vyhledávání - "Thomas G Davies"

Akademický článek

Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.

Autor: Anne Cleasby, Jeff Yon, Philip J Day, Caroline Richardson, Ian J Tickle, Pamela A Williams, James F Callahan, Robin Carr, Nestor Concha, Jeffrey K Kerns, Hongwei Qi, Thomas Sweitzer, Paris Ward, Thomas G Davies

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e98896 (2014)

The protein Keap1 is central to the regulation of the Nrf2-mediated cytoprotective response, and is increasingly recognized as an important target for therapeutic intervention in a range of diseases involving excessive oxidative stress and inflammati

Externí odkaz: https://doaj.org/article/e0c4767540824921bd96b680725f39ab

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Supplementary Methods, Figure Legends 1-7 from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

PDF file - 81K, Supplementary data comprising the materials and methods for (i) crystallography (ii) gene expression studies (iii) siRNA studies and Supplementary Figure legends 1-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136ef480c6dff64c10335140171ee9da
https://doi.org/10.1158/1078-0432.22446023.v1

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Supplementary Table 5B from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

XLS file - 703K, Gene expression data for CCT128930: Genes that showed at least a 1.5 Fold Change in at least one treated sample compared to vehicle control and were differentially expressed between the treatment groups (Welch ANOVA FDR5%)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264e5ae7347bb9dfece9541b75115729
https://doi.org/10.1158/1078-0432.22446017.v1

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Data from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dad559501b49bb682286db9d7d443d
https://doi.org/10.1158/1078-0432.c.6520622

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Supplementary Table 6C from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

XLS file - 66K, Genes that showed at least a 1.5 Fold Change in at least one treated sample compared to vehicle control and were differentially expressed between the treatment groups (Welch ANOVA FDR5%) for both CCT128930 and AT13148

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02505457843f17ab3c7bd679c87ef577
https://doi.org/10.1158/1078-0432.22446008

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Supplementary Figures 1-7, Tables 1-4 from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

PDF file - 553K, Supplementary Figure 1. Phosphorylation of AKT substrates remains suppressed, despite pSer473 AKT induction. Supplementary Figure 2. The pharmacokinetic-pharmacodynamic profile and antitumor activity of AT13148 in PTEN-deficient PC3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66309a130e6558ca6307e2e123bca36e
https://doi.org/10.1158/1078-0432.22446026

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Chimeric Investigations into the Diamide Binding Site on the Lepidopteran Ryanodine Receptor

Autor: Ralf Nauen, Ulrich Ebbinghaus-Kintscher, Christopher H. George, Oliver Gutbrod, Bartek J. Troczka, Thomas G. Davies, Ewan Richardson, Martin S. Williamson

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 13033, p 13033 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13033

Alterations to amino acid residues G4946 and I4790, associated with resistance to diamide insecticides, suggests a location of diamide interaction within the pVSD voltage sensor-like domain of the insect ryanodine receptor (RyR). To further delineate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ee2e4ab26c878b325f814edda92d8e
http://europepmc.org/articles/PMC8657592

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Baseline geochemical study of the Aberpergwm mining site in the South Wales Coalfield

Autor: Neil Price, Sivachidambaram Sadasivam, Hywel Rhys Thomas, Thomas G. Davies, Renato Zagorščak

Publikováno v: Journal of Geochemical Exploration. 202:100-112

This paper presents the baseline geochemistry and hydrogeology of a site in the South Wales Coalfield. Three deep exploration boreholes were drilled up to 650 m for that purpose and investigated together with the surrounding surface environment. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0257c0ce3a36e3ef361bd307e4b28b64
https://doi.org/10.1016/j.gexplo.2019.03.006

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Mutations in the voltage-gated sodium channel gene associated with deltamethrin resistance in commercially sourced Phytoseiulus persimilis

Autor: Thomas G. Davies, M. Alonso, L. Benavent‐Albarracín, Joel González-Cabrera, Alberto Urbaneja, José Catalán, Martin S. Williamson

Publikováno v: Benavent-Albarracín, Luis Alonso, Miquel Catalán, José Urbaneja García, Alberto Davies, Thomas G. Emyr Williamson, Martin S. González Cabrera, Joel 2020 Mutations in the voltage-gated sodium channel gene associated with deltamethrin resistance in commercially sourced Phytoseiulus persimilis Insect Molecular Biology
RODERIC. Repositorio Institucional de la Universitat de Valéncia
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The implementation of Integrated Pest Management (IPM) in current agricultural practice is a convenient and very effective strategy to maintain pest populations under control. The use of Biological Control Agents, like Phytoseiulus persimilis, is key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51fb207943150aed3197e3033126dd5
https://hdl.handle.net/10550/74196

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Developmental abnormalities of the otic capsule and inner ear following application of prolyl-hydroxylase inhibitors in chick embryos

Autor: Nobue Itasaki, Thomas G. Davies, Akshay Kumar

Publikováno v: Kumar, A, Davies, T G & Itasaki, N 2018, ' Developmental abnormalities of the otic capsule and inner ear following application of prolyl-hydroxylase inhibitors in chick embryos ', Birth Defects Research, vol. 110, no. 15, pp. 1194-1204 . https://doi.org/10.1002/bdr2.1375

Background Naturally hypoxic conditions in amniote embryos play important roles in normal development. We previously showed that a hypoxic condition is required to produce a sufficient amount of neural crest cells (NCCs) during embryogenesis and that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0f642a9f06a76e98586e5fea894b96
https://doi.org/10.1002/bdr2.1375

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