Supplementary Methods, Figure Legends 1-7 from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Autor: Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap

PDF file - 81K, Supplementary data comprising the materials and methods for (i) crystallography (ii) gene expression studies (iii) siRNA studies and Supplementary Figure legends 1-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136ef480c6dff64c10335140171ee9da
https://doi.org/10.1158/1078-0432.22446023.v1

Data from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Autor: Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap

Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dad559501b49bb682286db9d7d443d
https://doi.org/10.1158/1078-0432.c.6520622

Supplementary Figures 1-7, Tables 1-4 from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Autor: Michelle D. Garrett, Neil T. Thompson, Paul Workman, Suzanne A. Eccles, Florence I. Raynaud, John F. Lyons, Thomas G. Davies, Steven J. Woodhead, Matthias Reule, Ruth E. Feltell, Paul S. Jones, Kathrin Heinzmann, Simon P. Heaton, Anna Zetterlund, Vanessa Martins, Alexis K. de Haven Brandon, Melanie R. Valenti, Paul D. Eve, Robert H. te Poele, Kyla M. Grimshaw, Mike I. Walton, Timothy A. Yap

PDF file - 553K, Supplementary Figure 1. Phosphorylation of AKT substrates remains suppressed, despite pSer473 AKT induction. Supplementary Figure 2. The pharmacokinetic-pharmacodynamic profile and antitumor activity of AT13148 in PTEN-deficient PC3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66309a130e6558ca6307e2e123bca36e
https://doi.org/10.1158/1078-0432.22446026

Baseline geochemical study of the Aberpergwm mining site in the South Wales Coalfield

Autor: Neil Price, Sivachidambaram Sadasivam, Hywel Rhys Thomas, Thomas G. Davies, Renato Zagorščak

Publikováno v: Journal of Geochemical Exploration. 202:100-112

This paper presents the baseline geochemistry and hydrogeology of a site in the South Wales Coalfield. Three deep exploration boreholes were drilled up to 650 m for that purpose and investigated together with the surrounding surface environment. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0257c0ce3a36e3ef361bd307e4b28b64
https://doi.org/10.1016/j.gexplo.2019.03.006

Mutations in the voltage-gated sodium channel gene associated with deltamethrin resistance in commercially sourced Phytoseiulus persimilis

Autor: Thomas G. Davies, M. Alonso, L. Benavent‐Albarracín, Joel González-Cabrera, Alberto Urbaneja, José Catalán, Martin S. Williamson

Publikováno v: Benavent-Albarracín, Luis Alonso, Miquel Catalán, José Urbaneja García, Alberto Davies, Thomas G. Emyr Williamson, Martin S. González Cabrera, Joel 2020 Mutations in the voltage-gated sodium channel gene associated with deltamethrin resistance in commercially sourced Phytoseiulus persimilis Insect Molecular Biology
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname

The implementation of Integrated Pest Management (IPM) in current agricultural practice is a convenient and very effective strategy to maintain pest populations under control. The use of Biological Control Agents, like Phytoseiulus persimilis, is key

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51fb207943150aed3197e3033126dd5
https://hdl.handle.net/10550/74196