Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Thomas G Boyer"'
Autor:
Changming Tan, Siting Zhu, Zee Chen, Canzhao Liu, Yang E Li, Mason Zhu, Zhiyuan Zhang, Zhiwei Zhang, Lunfeng Zhang, Yusu Gu, Zhengyu Liang, Thomas G Boyer, Kunfu Ouyang, Sylvia M Evans, Xi Fang
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009785 (2021)
Dysregulation of cardiac transcription programs has been identified in patients and families with heart failure, as well as those with morphological and functional forms of congenital heart defects. Mediator is a multi-subunit complex that plays a ce
Externí odkaz:
https://doaj.org/article/18fca6d6e79348038660f42598de6a01
Publikováno v:
Cells, Vol 13, Iss 17, p 1443 (2024)
Uterine leiomyosarcoma (uLMS) is the most common type of uterine sarcoma, associated with poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular mechanism of the origin and development of uLMS is limited. Bromodomain and e
Externí odkaz:
https://doaj.org/article/5645efaaa8624612a6e767075703824a
Autor:
Azna Zuberi, Yongchao Huang, Ariel J. Dotts, Helen Wei, John S. Coon V, Shimeng Liu, Takashi Iizuka, Olivia Wu, Olivia Sotos, Priyanka Saini, Debabrata Chakravarti, Thomas G. Boyer, Yang Dai, Serdar E. Bulun, Ping Yin
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiomyomas that
Externí odkaz:
https://doaj.org/article/d0e7da5cad5e4be6b2a1e703a85ac26f
Autor:
Marius V. Dannappel, Danxi Zhu, Xin Sun, Hui Kheng Chua, Marle Poppelaars, Monica Suehiro, Subash Khadka, Terry C.C. Lim Kam Sian, Dhanya Sooraj, Melissa Loi, Hugh Gao, Daniel Croagh, Roger J. Daly, Pouya Faridi, Thomas G. Boyer, Ron Firestein
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 20 (2022)
Initiation and maintenance of transcriptional states are critical for controlling normal tissue homeostasis and differentiation. The cyclin dependent kinases CDK8 and CDK19 (Mediator kinases) are regulatory components of Mediator, a highly conserved
Externí odkaz:
https://doaj.org/article/3d46bbee8ab546fa96a8734f41d7728e
Autor:
Chun Liang Chen, Tim H M Huang, Xiang Gu, Thu Minh Duong, Marieke Burleson, Haojie Huang, Yuqian Yan, Yi Zou, Michael A. Liss, Thomas G. Boyer, Lu-Zhe Sun, P. Renee Yew, Acarizia Easley, Addanki P. Kumar, Debodipta Das, Janice Jianhong Deng, Yi Chen, Tai Qin, Roble Bedolla
Publikováno v:
Mol Cancer Res
Although the Sonic hedgehog (SHH) signaling pathway has been implicated in promoting malignant phenotypes of prostate cancer, details on how it is activated and exerts its oncogenic role during prostate cancer development and progression is less clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ce740d5638259a84c2bc8945818a08
https://doi.org/10.1158/1541-7786.mcr-21-0108
https://doi.org/10.1158/1541-7786.mcr-21-0108
Autor:
Qiwei Yang, Ali Falahati, Azad Khosh, Hanaa Mohammed, Wenjun Kang, Ana Corachán, Maria Victoria Bariani, Thomas G. Boyer, Ayman Al-Hendy
Publikováno v:
Cells; Volume 11; Issue 23; Pages: 3801
Uterine leiomyosarcoma (uLMS) is the most frequent subtype of uterine sarcoma that presents a poor prognosis, high rates of recurrence, and metastasis. Currently, the molecular mechanism of the origin and development of uLMS is unknown. Class I histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685901d5d96c230559ba29b3e87705b7
Autor:
Mikko Turunen, Jason M. Spaeth, Salla Keskitalo, Min Ju Park, Teemu Kivioja, Alison D. Clark, Netta Mäkinen, Fangjian Gao, Kimmo Palin, Helka Nurkkala, Anna Vähärautio, Mervi Aavikko, Kati Kämpjärvi, Pia Vahteristo, Chongwoo A. Kim, Lauri A. Aaltonen, Markku Varjosalo, Jussi Taipale, Thomas G. Boyer
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 654-660 (2014)
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at very high frequency (∼70%) in uterine leiomyomas. However, the influence of these mutations on Mediator function and the molecular basis for their
Externí odkaz:
https://doaj.org/article/59206a3393054e17a8c174a02fdf6b30
Publikováno v:
IEEE Sensors Journal. 21:3013-3019
Timely detection of the incipient fault of a power transformer is of utmost importance to prevent potential malfunctioning. Monitoring the condition of the transformer insulation oil is the essential step as it contains most of the transformer’s he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd11b6dc90f95d446012223ca2065eaf
https://doi.org/10.1109/jsen.2020.3024943
https://doi.org/10.1109/jsen.2020.3024943
Autor:
Sribalasubashini, Muralimanoharan, Ross, Shamby, Nicholas, Stansbury, Robert, Schenken, Barbara, de la Pena Avalos, Samin, Javanmardi, Eloise, Dray, Patrick, Sung, Thomas G, Boyer
Publikováno v:
Scientific Reports. 12
Uterine fibroid (UF) driver mutations in Mediator complex subunit 12 (MED12) trigger genomic instability and tumor development through unknown mechanisms. Herein, we show that MED12 mutations trigger aberrant R-loop-induced replication stress, sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91f7cce2e94d7ea9ef52da4861a59a0
https://doi.org/10.1038/s41598-022-10188-x
https://doi.org/10.1038/s41598-022-10188-x
Publikováno v:
Reprod Sci
Uterine fibroids (UFs) or leiomyoma are frequently associated with somatic mutations in the mediator complex subunit 12 (MED12) gene; however, the function of these mutations in human UF biology is yet to be determined. Herein, we determined the func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3714d7020056d37434b4e8077c8b29
https://doi.org/10.1007/s43032-019-00084-7
https://doi.org/10.1007/s43032-019-00084-7