Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Thomas G, McWilliams"'
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-20 (2021)
Abstract The cardinal stages of macroautophagy are driven by core autophagy‐related (ATG) proteins, whose ablation largely abolishes intracellular turnover. Disrupting ATG genes is paradigmatic of studying autophagy deficiency, yet emerging data su
Externí odkaz:
https://doaj.org/article/0925a012019a43c79630e3d05adcb9b8
Autor:
Anna Rappe, Thomas G. McWilliams
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Aging is characterised by the progressive accumulation of cellular dysfunction, stress, and inflammation. A large body of evidence implicates mitochondrial dysfunction as a cause or consequence of age-related diseases including metabolic disorders, n
Externí odkaz:
https://doaj.org/article/75326fd1afe94b48a4e542c724597c97
Autor:
Sara Feola, Manlio Fusciello, Beatriz Martins, Erkko Ylösmäki, Vincenzo Cerullo, Firas Hamdan, Jacopo Chiaro, Yvonne Giannoula, Maeve Long, Michaela Feodoroff, Gabriella Antignani, Salvatore Russo, Otto Kari, Petrus Järvinen, Harry Nisen, Anna Kreutzman, Satu Mustjoki, Thomas G McWilliams, Mikaela Grönholm, Moon Hee Lee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Background Despite the success of immune checkpoint inhibitors against PD-L1 in the clinic, only a fraction of patients benefit from such therapy. A theoretical strategy to increase efficacy would be to arm such antibodies with Fc-mediated effector m
Externí odkaz:
https://doaj.org/article/75228aef30a64c3b90f489f356c51753
Publikováno v:
Trends in Neurosciences. 46:137-152
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::224d9a2f8316c536505754cead984050
https://doi.org/10.1016/j.tins.2022.12.001
https://doi.org/10.1016/j.tins.2022.12.001
Autor:
Villo Muha, Ritchie Williamson, Rachel Hills, Alison D. McNeilly, Thomas G. McWilliams, Jana Alonso, Marianne Schimpl, Aneika C. Leney, Albert J. R. Heck, Calum Sutherland, Kevin D. Read, Rory J. McCrimmon, Simon P. Brooks, Daan M. F. van Aalten
Publikováno v:
Open Biology, Vol 9, Iss 11 (2019)
O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain la
Externí odkaz:
https://doaj.org/article/9e64e5af2f29476f9e4eeb84d52a4cc3
Autor:
Elina Järvinen, Fumi Suomi, James B. Stewart, Dimitri Guala, Miko Valori, Lilja Jansson, Janne Nieminen, Thomas G. McWilliams, Pentti Tienari
Cladribine tablets are a treatment for multiple sclerosis (MS) with effects on lymphocytes’, yet its mode of action has not been fully established. Here, we evaluated the effects of cladribine on mitochondrial DNA integrity in human lymphocytes. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d18998d635d3ec7e0a25180e2663a28f
https://doi.org/10.21203/rs.3.rs-2672926/v1
https://doi.org/10.21203/rs.3.rs-2672926/v1
Autor:
Thomas G. McWilliams
Publikováno v:
Journal of Cell Biology. 222
When mitochondrial damage threatens to disrupt cell and tissue homeostasis, selective autophagy (mitophagy) provides an important route to neutralize dysfunctional organelles. Whilst we understand much about stress-induced mitophagy, steady-state and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::131417fb5fffd5a6ee2c06c57c90f887
https://doi.org/10.1083/jcb.202302118
https://doi.org/10.1083/jcb.202302118
Autor:
Thomas G. McWilliams, Erica Barini, Risto Pohjolan-Pirhonen, Simon P. Brooks, François Singh, Sophie Burel, Kristin Balk, Atul Kumar, Lambert Montava-Garriga, Alan R. Prescott, Sidi Mohamed Hassoun, François Mouton-Liger, Graeme Ball, Rachel Hills, Axel Knebel, Ayse Ulusoy, Donato A. Di Monte, Jevgenia Tamjar, Odetta Antico, Kyle Fears, Laura Smith, Riccardo Brambilla, Eino Palin, Miko Valori, Johanna Eerola-Rautio, Pentti Tienari, Olga Corti, Stephen B. Dunnett, Ian G. Ganley, Anu Suomalainen, Miratul M. K. Muqit
Publikováno v:
Open Biology, Vol 8, Iss 11 (2018)
Mutations in PINK1 and Parkin result in autosomal recessive Parkinson's disease (PD). Cell culture and in vitro studies have elaborated the PINK1-dependent regulation of Parkin and defined how this dyad orchestrates the elimination of damaged mitocho
Externí odkaz:
https://doaj.org/article/1d714fdf77f7434a8620cf73ff0a6aee
Publikováno v:
Cell Metabolism. 35:553-554
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af48d7afbea0f6ee71c2c412210ac2bd
https://doi.org/10.1016/j.cmet.2023.03.012
https://doi.org/10.1016/j.cmet.2023.03.012
Publikováno v:
Cell Reports, Vol 10, Iss 9, Pp 1443-1449 (2015)
The regulation of innervation by target-derived factors like nerve growth factor (NGF) is the cornerstone of neurotrophic theory. Whereas autocrine signaling in neurons affecting survival and axon growth has been described, it is difficult to reconci
Externí odkaz:
https://doaj.org/article/e6bc153f3e4a48c788ddf60481a613d6