Zobrazeno 1 - 10
of 871
pro vyhledávání: '"Thomas G, Martin"'
Autor:
Stephen Palmer, Yi Lin, Thomas G. Martin, Sundar Jagannath, Andrzej Jakubowiak, Saad Z. Usmani, Nasuh Buyukkaramikli, Hilary Phelps, Rafal Slowik, Feng Pan, Satish Valluri, Lida Pacaud, Graham Jackson
Publikováno v:
Oncology and Therapy, Vol 11, Iss 3, Pp 313-326 (2023)
Abstract Introduction Extrapolating long-term overall survival (OS) from shorter-term clinical trial data is key to health technology assessment in oncology. However, extrapolation using conventional methods is often subject to uncertainty. Using cil
Externí odkaz:
https://doaj.org/article/bf4c2994be6c42d0a5ac48bafa27bb4e
Autor:
Thomas G. Martin, Hana Pak, Glenn S. Gerhard, Salim Merali, Carmen Merali, Bonnie Lemster, Praveen Dubey, Charles F. McTiernan, Michael R. Bristow, Arthur M. Feldman, Jonathan A. Kirk
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 24 (2023)
Background Mutations to the co‐chaperone protein BAG3 (B‐cell lymphoma‐2–associated athanogene‐3) are a leading cause of dilated cardiomyopathy (DCM). These mutations often impact the C‐terminal BAG domain (residues 420–499), which regu
Externí odkaz:
https://doaj.org/article/e00324252d774fae9058422acc540cab
Autor:
Aurore Perrot, Paul Richardson, Joseph Mikhael, Thomas G. Martin, Meral Beksac, Ivan Spicka, Marcelo Eduardo Capra, Mattia D’agostino, Pieter Sonneveld, Kamlesh Bisht, Taro Fukao, Rick Zhang, Keisuke Tada, Christina Tekle, Sandrine Macé, Zandra Klippel, Helgi van de Velde, Philippe Moreau
Publikováno v:
HemaSphere, Vol 7, p e3398301 (2023)
Externí odkaz:
https://doaj.org/article/5bf02ff2dab540669ea5d09505ce72e3
Autor:
Ian D. Ferguson, Bonell Patiño-Escobar, Sami T. Tuomivaara, Yu-Hsiu T. Lin, Matthew A. Nix, Kevin K. Leung, Corynn Kasap, Emilio Ramos, Wilson Nieves Vasquez, Alexis Talbot, Martina Hale, Akul Naik, Audrey Kishishita, Priya Choudhry, Antonia Lopez-Girona, Weili Miao, Sandy W. Wong, Jeffrey L. Wolf, Thomas G. Martin, Nina Shah, Scott Vandenberg, Sonam Prakash, Lenka Besse, Christoph Driessen, Avery D. Posey, R. Dyche Mullins, Justin Eyquem, James A. Wells, Arun P. Wiita
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The myeloma cell surface proteome regulates plasma cell biology and delineates therapy targets. Here, the authors profile the myeloma surfaceome at baseline and in drug resistance, finding the potential target CCR10, and include a streamlined approac
Externí odkaz:
https://doaj.org/article/c60c92825695486592fb827ec64cf75c
Autor:
Amrita Krishnan, Ajay K Nooka, Ajai Chari, Alfred L Garfall, Thomas G Martin, Sandhya Nair, Xiwu Lin, Keqin Qi, Anil Londhe, Lixia Pei, Eric Ammann, Rachel Kobos, Jennifer Smit, Trilok Parekh, Alexander Marshall, Mary Slavcev, Saad Z Usmani
Publikováno v:
Journal of Comparative Effectiveness Research, Vol 12, Iss 6 (2023)
Aim: We compared the effectiveness of teclistamab versus real-world physician’s choice of therapy (RWPC) in triple-class exposed relapsed/refractory multiple myeloma. Materials & methods: MajesTEC- 1 eligibility criteria were applied to the RWPC
Externí odkaz:
https://doaj.org/article/d2234f01c82748d787b0b8d1a00b2e7e
Autor:
Rahul Banerjee, Ann A. Lazar, Lisa Dunn, Jennifer Knoche, Mimi Lo, Shagun Arora, Sandy W. Wong, Jeffrey L. Wolf, Thomas G. Martin III, Anand Dhruva, Nina Shah
Publikováno v:
eJHaem, Vol 2, Iss 2, Pp 276-279 (2021)
Abstract Multiple myeloma patients undergoing autologous stem cell transplantation (ASCT) may receive benzodiazepine or zolpidem‐class (B/Z) medications despite their risks in older patients. Of 205 myeloma patients (36% aged 65+) who underwent ASC
Externí odkaz:
https://doaj.org/article/e518401584a44be7a7aabbb0936cbf09
Autor:
Joseph Mikhael, Karim Belhadj-Merzoug, Cyrille Hulin, Laure Vincent, Philippe Moreau, Cristina Gasparetto, Ludek Pour, Ivan Spicka, Ravi Vij, Jeffrey Zonder, Djordje Atanackovic, Nashat Gabrail, Thomas G. Martin, Aurore Perrot, Samira Bensfia, Qilong Weng, Claire Brillac, Dorothée Semiond, Sandrine Macé, Kathryn P. Corzo, Xavier Leleu
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 5, Pp 1-5 (2021)
Externí odkaz:
https://doaj.org/article/e988d77002f64e06a56cefb6125e9b40
Autor:
Thomas G. Martin, Valerie D. Myers, Praveen Dubey, Shubham Dubey, Edith Perez, Christine S. Moravec, Monte S. Willis, Arthur M. Feldman, Jonathan A. Kirk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Decreased expression of BAG3 in the heart is associated with contractile dysfunction and heart failure. Here the authors show that this is due to decreased BAG3-dependent sarcomere protein turnover, which impairs mechanical function, and that sarcome
Externí odkaz:
https://doaj.org/article/e8b11b6fcce64e39a9fa3c8e82869801
BAG3: Nature’s Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular Glue
Autor:
Caitlyn M. Brenner, Muaaz Choudhary, Michael G. McCormick, David Cheung, Gavin P. Landesberg, Ju-Fang Wang, Jianliang Song, Thomas G. Martin, Joseph Y. Cheung, Hui-Qi Qu, Hakon Hakonarson, Arthur M. Feldman
Publikováno v:
Cells, Vol 12, Iss 6, p 937 (2023)
BAG3 is a 575 amino acid protein that is found throughout the animal kingdom and homologs have been identified in plants. The protein is expressed ubiquitously but is most prominent in cardiac muscle, skeletal muscle, the brain and in many cancers. W
Externí odkaz:
https://doaj.org/article/3da901bbcdc74b2c9ceef3cef1832caf
Autor:
Massimo Kube, Fabian Kohler, Elija Feigl, Baki Nagel-Yüksel, Elena M. Willner, Jonas J. Funke, Thomas Gerling, Pierre Stömmer, Maximilian N. Honemann, Thomas G. Martin, Sjors H. W. Scheres, Hendrik Dietz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Precision design of DNA origami needs precision validation. Here, the authors developed cryo-EM methods for obtaining high resolution structural data and for constructing pseudo-atomic models in a semi-automated fashion, allowing for iterative nanode
Externí odkaz:
https://doaj.org/article/fef625b2e3904bd18533db01a9a93d13